Results 51 to 60 of about 123,953 (269)
Reconstructing data-driven governing equations for cell phenotypic transitions: integration of data science and systems biology [PDF]
, 2022 Cells with the same genome can exist in different phenotypes. and can change between distinct phenotypes when subject to specific stimuli and microenvironments. Some examples include cell differentiation during development, reprogramming for induced pluripotent stem cells and transdifferentiation, cancer metastasis and fibrosis development.
arxiv +1 more source
Comparison of Developmental Efficiency of Murine Somatic Cell Nuclear Transfer Protocol
Journal of Animal Reproduction and Biotechnology, 2017 The Somatic cell nuclear transfer (SCNT) method can be applied to various fields such as species conservation, regenerative medicine, farming industries and drug production. However, the efficiency using SCNT is very low for many reasons.
Jeonghyeon Moon, Miran Jung, Sangho Roh
doaj +1 more source
A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells [PDF]
Biochim Biophys Acta. Gene Regulatory Mechanisms 2017
Feb;1860(2):184-195, 2017 Despite their dynamic nature, certain chromatin marks must be maintained over the long term. This is particulary true for histone 3 lysine 9 (H3K9) trimethylation, that is involved in the maintenance of healthy differentiated cellular states by preventing inappropriate gene expression, and has been recently identified as the most efficient barrier to ...
arxiv +1 more source
Cellular reprogramming and pluripotency induction [PDF]
British Medical Bulletin, 2009 Cellular reprogramming is the process of directing mature cells to a primitive state of gene expression.Medline searches using the keywords 'pluripotency', 'induce' (and derivatives), and/or 'stem' limited to the years 2006 to the present and other selected literature known to the author.Since 2006, there has been a cavalcade of scientific works ...
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Stem Cell Research, 2017 Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component.
Cristina Mora +11 more
doaj +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Pluripotency, differentiation, and reprogramming: A gene expression dynamics model with epigenetic feedback regulation [PDF]
, 2015 Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these processes is essential to the reprogramming of cells for biomedical applications, i.e., the experimental recovery of ...
arxiv +1 more source
Mechanisms for enhancing cellular reprogramming [PDF]
Current Opinion in Genetics & Development, 2014 During development, the genome adopts specific chromatin states to establish and maintain functionally distinct cell types in a well-controlled environment. A select group of transcription factors have the ability to drive the transition of the genome from a pluripotent to a more specialized chromatin state.
openaire +3 more sources
Dynamical systems theory of cellular reprogramming
Physical Review Research, 2022 15 pages, 12 ...
Yuuki Matsushita +2 more
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FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source