Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming [PDF]
Cancer is a disorder with various genetic and epigenetic alterations. Genetic alterations such as mutations, i.e., substitutions, amplifications, and deletions of nucleotide sequences, are largely irreversible, whereas epigenetic alterations can be ...
Dyah Laksmi Dewi+9 more
core +2 more sources
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works as a survival mechanism that allows the generation of metabolic ...
Laura Gómez-Virgilio+11 more
doaj +1 more source
Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J+15 more
core +3 more sources
Visual function restoration in genetically blind mice via endogenous cellular reprogramming
In this study, we developed an in-situ cellular reprogramming strategy for potent restoration of vision in advanced/end-stage retinitis pigmentosa (RP). Via repressing PTB, an RNA binding protein critical for converting non-neuronal cells to the neuronal
Xin Fu+10 more
semanticscholar +1 more source
Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro+4 more
core +5 more sources
Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. [PDF]
The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor ...
Bagai, Rakesh+14 more
core +1 more source
Direct Cardiac Reprogramming: Progress and Promise. [PDF]
The human adult heart lacks a robust endogenous repair mechanism to fully restore cardiac function after insult; thus, the ability to regenerate and repair the injured myocardium remains a top priority in treating heart failure.
Ardehali, Reza, Engel, James L
core +3 more sources
A stochastic model dissects cell states in biological transition processes [PDF]
Many biological processes, including differentiation, reprogramming, and disease transformations, involve transitions of cells through distinct states.
Armond, Jonathan W.+6 more
core +3 more sources
Epigenetic Control of Reprogramming and Cellular Differentiation [PDF]
Recently, numerous interdisciplinary approaches that include integration of bioinformatics, epigenetics, and molecular and cellular biology have started to shed light on the complex dynamics that regulate cellular processes such as cell “stemness,” reprogramming, and differentiation.
Lucia Latella+3 more
openaire +4 more sources
Reprogramming cellular identity in vivo [PDF]
ABSTRACT Cellular identity is established through complex layers of genetic regulation, forged over a developmental lifetime. An expanding molecular toolbox is allowing us to manipulate these gene regulatory networks in specific cell types in vivo.
Sydney Leaman+2 more
openaire +4 more sources