Results 61 to 70 of about 224,348 (348)
The Journal of Reproduction and DevelopmentIn vitro production of porcine-hatched blastocysts is important for various applications. However, the mechanobiology of blastocoel expansion and hatching remains poorly understood.
Ba Anh My LE +6 more
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Molecular versatility during pluripotency progression
Nature Communications, 2023 During development the embryo must balance lineage specification against the preservation of plasticity using a limited molecular toolkit. In this Perspective, the authors propose Molecular Versatility as a paradigm for grouping molecular mechanisms that
Giacomo Furlan +3 more
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Stem Cell Research, 2021 Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative condition with phenotypic and genetic heterogeneity. It is characterized by the selective vulnerability and the progressive loss of the neural population.
Angela D'Anzi +9 more
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Cellular reprogramming and pluripotency induction [PDF]
British Medical Bulletin, 2009 Cellular reprogramming is the process of directing mature cells to a primitive state of gene expression.Medline searches using the keywords 'pluripotency', 'induce' (and derivatives), and/or 'stem' limited to the years 2006 to the present and other selected literature known to the author.Since 2006, there has been a cavalcade of scientific works ...
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Cellular decision-making bias: the missing ingredient in cell functional diversity
, 2013 Cell functional diversity is a significant determinant on how biological processes unfold. Most accounts of diversity involve a search for sequence or expression differences. Perhaps there are more subtle mechanisms at work.
Alicea, Bradly
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Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach [PDF]
, 2010 Background: Several methods have been used to induce somatic cells to re-enter the pluripotent state. Viral transduction of reprogramming genes yields higher efficiency but involves random insertions of viral sequences into the human genome.
Andrews, P.W. +6 more
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Mechanisms for enhancing cellular reprogramming [PDF]
Current Opinion in Genetics & Development, 2014 During development, the genome adopts specific chromatin states to establish and maintain functionally distinct cell types in a well-controlled environment. A select group of transcription factors have the ability to drive the transition of the genome from a pluripotent to a more specialized chromatin state.
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Dynamical systems theory of cellular reprogramming
Physical Review Research, 2022 15 pages, 12 ...
Yuuki Matsushita +2 more
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Krüppel-like factors in cancer progression: three fingers on the steering wheel [PDF]
, 2013 Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency.
de Beeck, Ken Op +4 more
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HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation [PDF]
, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Allen, George F. G. +4 more
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