Results 241 to 250 of about 1,861,365 (381)

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Cellular senescence in the glaucomatous outflow pathway [PDF]

, 2005
Paloma B. Liton, Pratap Challa, Sandra S. Stinnett, Coralia Luna, David L. Epstein, Pedro González   +5 more
openalex   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

The Regulation of Cellular Senescence in Cancer. [PDF]

Biomolecules
Zhang X, Gao Y, Zhang S, Wang Y, Du Y, Hao S, Ni T.   +6 more
europepmc   +1 more source

Constitutive Induction of p-Erk1/2 Accompanied by Reduced Activities of Protein Phosphatases 1 and 2A and MKP3 Due to Reactive Oxygen Species during Cellular Senescence

, 2003
Hong Seok Kim, Myeong-Cheol Song, In Hae Kwak, Tae Jun Park, In Kyoung Lim   +4 more
openalex   +1 more source

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis [PDF]

, 2005
Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer, Hui‐Kuan Lin, Zohar Dotan, Masaru Niki, Jason A. Koutcher, Howard I. Scher, Thomas Ludwig, William L. Gerald, Carlos Cordón-Cardo, Pier Paolo Pandolfi   +11 more
openalex   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Tacrolimus may play a role in dermatitis and radiation-induced skin injury through cellular senescence

Radiation Medicine and Protection
Skin Exposure of skin to ionizing radiation can induce acute or chronic biological effects, resulting in radiation-induced skin injury (RSI). Premature cellular senescence, caused by oxidative stress and/or DNA damage from chemical or physical agents ...
Jie Chen, Ling Gao
doaj  

Cellular senescence and other age-related mechanisms in skeletal diseases. [PDF]

Bone Res
Li K, Hu S, Chen H.
europepmc   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source