Anti-Tumor Activity of Cembranoid-Type Diterpenes Isolated from Nicotiana tabacum L. [PDF]
Biomolecules, 2019 Recently, the incidence of hepatocellular carcinoma has increased worldwide. Cembranoid-type diterpenes (CBDs) from tobacco exhibit good antimicrobial, antitumor, and neuroprotective activities.
Xiao-Long Yuan +5 more
doaj +2 more sources
New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris [PDF]
Molecules, 2015 Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known ...
Ting-Hsi Hsiao +8 more
doaj +3 more sources
Systematic Route to Construct the 5-5-6 Tricyclic Core of Furanobutenolide-Derived Cembranoids and Norcembranoids. [PDF]
Org LettChan M +3 more
europepmc +3 more sources
Phytochemicals derived from Nicotiana tabacum L. plant contribute to pharmaceutical development [PDF]
Frontiers in PharmacologyThe Nicotiana tabacum L. plant, a medicinal resource, holds significant potential for benefiting human health, as evidenced by its use in Native American and ancient Chinese cultures.
Wenji Zhang +6 more
doaj +2 more sources
Determining the safety of the tobacco cembranoid (1S,2E,4R,6R,7E,11E)-Cembratriene-4,6-diol (4R): A translational study in nonhuman primates. [PDF]
Toxicol Appl Pharmacol, 2023 Sabeva N +8 more
europepmc +2 more sources
Bioactive Cembranoids from the Soft Coral Sinularia crassa [PDF]
Marine Drugs, 2011 Eight new cembranoids, crassarines A–H (1–8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1–3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids.
Chih‐Hua Chao +7 more
openalex +5 more sources
4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice. [PDF]
J Neurosci Res4R‐cembranoid is a natural compound that protects neurons against LPS‐induced neuroinflammation by reducing the number of pro‐inflammatory microglia and by promoting the secretion of astrocytic neuroprotective factors in the mice hippocampus. Abstract Chronic neuroinflammation has been implicated in neurodegenerative disease pathogenesis. A key feature
Rojas-Colón LA +4 more
europepmc +2 more sources
4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration [PDF]
NeuroToxicology, 2014 Many organophosphorous esters synthesized for applications in industry, agriculture, or warfare irreversibly inhibit acetylcholinesterase, and acute poisoning with these compounds causes life-threatening cholinergic overstimulation. Following classical emergency treatment with atropine, an oxime, and a benzodiazepine, surviving victims often suffer ...
P.A. Ferchmin +11 more
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Beiträge zur Tabakforschung / Contributions to Tobacco Research, 1984 AbstractThe discovery of the first diterpenoids of the cembrane type in tobacco dates back to the early 1960's. Since then some forty tobacco cembranoids have been encountered. Most of these have a hydroxyl substituent at C-4 and are commonly divided into two series: those having a 4R- and those having a 4S-configuration.
I. Wahlberg, C. R. Enzell
openaire +1 more source
Food and Energy Security, Volume 12, Issue 5, September 2023., 2023 Abstract As one of the most destructive pests, aphids cause significant damage on various agricultural and horticultural crops. Recently, melatonin has been shown to enhance plant resistance to aphids; however, the underlying mechanisms remain unclear.
Zhuangzhuang Su +10 more
wiley +1 more source