Results 111 to 120 of about 113,938,265 (213)
A long non-coding RNA is required for targeting centromeric protein A to the human centromere
eLife, 2014 The centromere is a specialized chromatin region marked by the histone H3 variant CENP-A. Although active centromeric transcription has been documented for over a decade, the role of centromeric transcription or transcripts has been elusive.
Delphine Quénet, Yamini Dalal
doaj +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Guarding the Genome: CENP-A-Chromatin in Health and Cancer
, 2020 Faithful chromosome segregation is essential for the maintenance of genomic integrity and requires functional centromeres. Centromeres are epigenetically defined by the histone H3 variant, centromere protein A (CENP-A).
Yael Nechemia-Arbely +3 more
core +1 more source
CENP-A and centromere evolution in equids
Chromosome ResearchWhile the centromeric function is conserved and epigenetically specified by CENP-A, centromeric DNA, typically composed of satellite repeats, is highly divergent and rapidly evolving. In the species of the genus Equus (horses, asses and zebras), also known as equids, the numerous centromeres devoid of satellite repeats enabled us to carry out molecular
Eleonora Cappelletti +8 more
openaire +2 more sources
CENP-F promotes HCC cell proliferation mediated by super enhancer reader BRD4
Discover OncologyCentromere protein F (CENP-F) is highly expressed in hepatocellular carcinoma (HCC), but the specific mechanism by which it regulates the occurrence and development of HCC is currently unclear.
Yunhui Liu +5 more
doaj +1 more source
, 2016 The centromere-specific histone CENP-A is the key epigenetic determinant of centromere identity. Whereas most histones are removed from mature sperm, CENP-A is retained to mark paternal centromeres.
Dattoli, Anna A. +3 more
core +1 more source
Tipping the balance in histone supply puts genome stability at stake
The EMBO JournalSpecific localization of the histone H3 variant CENP-A at centromeres is key for faithful chromosome segregation during cell division, with CENP-A mislocalization being associated with chromosomal instability and cancer.
Charlène Renaud-Pageot +1 more
doaj +1 more source
iScienceSummary: To establish bipolar attachments of microtubules to sister chromatids, an inner kinetochore subcomplex, the constitutive centromere-associated network (CCAN), is assembled on centromeric chromatin and recruits the microtubule-binding subcomplex ...
Yusuke Takenoshita +4 more
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KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C
Cell ReportsChromosome congression is a key process that acts to align chromosomes at the spindle equator via kinetochore-microtubule interactions, with defects in chromosome alignment leading to chromosomal instability. However, defining the mechanisms that underlie chromosome congression is limited due to the multiple factors that act in parallel to regulate ...
Jiahang Miao +7 more
openaire +2 more sources
CENP-C can interact with CENP-A and histone H3 through its C-terminal domain.
, 2013 (A) HA::CENP-A coimmunoprecipitates the endogenous CENP-C. HEK-293 cells were transfected with HA::CENP-A or with the HA empty vector (pcDNA3.1HA) and HA proteins were purified from nuclear extracts with anti-HA affinity matrix.
Monica Zoli (372260) +6 more
core +1 more source