Results 91 to 100 of about 113,938,265 (213)
High-resolution analysis of human centromeric chromatin
Life Science AllianceCentromeres contain two physically distinct CENP-A nucleosomes, one of which associates with the CENP-C complex, and regulating CENP-C levels is critical for accessibility of the centromeric chromatin fiber for transcriptional machinery.
Daniël P Melters +5 more
doaj +1 more source
The Secret (Mitotic) Life of Clathrin
Traffic, Volume 27, Issue 3, September 2026.A perspective on the function of clathrin at the mitotic spindle during cell division. ABSTRACT The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of endocytosis. During
Stephen J. Royle
wiley +1 more source
CENP-A localization to the 8q24 locus is common feature of cancer cells.
, 2018 A.) Images showing breast or lung cells isolated from normal or tumor tissue immunolabeled for CENP-C and FISH for 8q24. Yellow arrowheads indicate colocalization.
David Sturgill (15686) +3 more
core +1 more source
Scientific ReportsCENP-F is a large protein acting in fundamental cell cycle processes, including nuclear envelope breakdown, mitotic microtubule function and chromosome segregation.
Ludovica Altieri +9 more
doaj +1 more source
The EMBO JournalThe centromeric histone H3 variant CENP-A is overexpressed in many cancers. The mislocalization of CENP-A to noncentromeric regions contributes to chromosomal instability (CIN), a hallmark of cancer.
Vinutha Balachandra +17 more
doaj +1 more source
Plant Biology, Volume 28, Issue 5, Page 1737-1742, August 2026.Cytogenetic quantification of KNL1‐labelled kinetochores in Ornithogalum kochii reveals a significant positive scaling relationship between chromosome size and kinetochore size, demonstrating that chromosome–kinetochore scaling operates even across moderate intra‐karyotype size variation.
K. Panda, M. Hroneš, F. Zedek
wiley +1 more source
ACR Open Rheumatology, Volume 8, Issue 7, July 2026.Objective Hand disability is a major musculoskeletal functional impairment in systemic sclerosis (SSc), but its objective assessment remains challenging. The validated Hand Test System (HTS) engineered glove has provided quantitative dexterity data in rheumatic diseases.
Alberto Sulli +10 more
wiley +1 more source
Identification and characterization of CENP-Aᶜⁿᵖ¹-associated proteins in Schizosaccharomyces pombe [PDF]
, 2019 Centromeres are chromosomal regions on each chromosome crucial for the assembly of the kinetochore which facilitates the binding of the microtubules and subsequently leads to accurate chromosome segregation during mitosis and meiosis.
Singh, Puneet Prabhakar
core +1 more source
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
CENP-ACse4 mislocalization does not depend on H2A.ZHtz1 incorporation.
, 2016 (A) ChIP was performed with anti-Cse4 antibody on negative control cells (SBY15924), as well as pTET-CSE4 (SBY15903), psh1Δ pTET-CSE4 (SBY15904) and psh1Δ htz1Δ pTET-CSE4 (SBY15906) cells overexpressing CENP-ACse4 for six hours.
Sue Biggins (280260) +1 more
core +1 more source