Results 101 to 110 of about 113,938,265 (213)
CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly [PDF]
, 2020 CENP-B binds to CENP-B boxes on centromeric satellite DNAs (alphoid DNA in human). CENP-B maintains kinetochore function through interactions with CENP-A nucleosomes and CENP-C. CENP-B binding to transfected alphoid DNA can induce de novo CENP-A assembly,
Kouprina, Natalay +11 more
core +1 more source
Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4.
PLoS Genetics, 2007 The histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regulated.
Araceli G Castillo +6 more
doaj +1 more source
Role of DNA sequence in CENP-ACnp1 assembly at fission yeast centromeres [PDF]
, 2013 The centromere is the site of kinetochore assembly that ensures proper chromosome segregation. Active centromeres are formed at chromosomal locations that do not appear to share homology between different species; this and other analyses has lead to ...
Catania, Sandra
core +3 more sources
Cenp-meta is required for sustained spindle checkpoint
Biology Open, 2014 Cenp-E is a kinesin-like motor protein required for efficient end-on attachment of kinetochores to the spindle microtubules. Cenp-E immunodepletion in Xenopus mitotic extracts results in the loss of mitotic arrest and massive chromosome missegregation ...
Thomas Rubin +2 more
doaj +1 more source
CENP-A Ubiquitylation Is Required for CENP-A Deposition at the Centromere [PDF]
Developmental Cell, 2017 Yohei, Niikura +2 more
openaire +2 more sources
Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome
Biophysics and Physicobiology, 2019 Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of about 150 bp is wrapped around a histone core almost twice.
Hidetoshi Kono +2 more
doaj +1 more source
RbAp46/48LIN-53 Is Required for Holocentromere Assembly in Caenorhabditis elegans
Cell Reports, 2016 Centromeres, the specialized chromosomal regions for recruiting kinetochores and directing chromosome segregation, are epigenetically marked by a centromeric histone H3 variant, CENP-A.
Bernard Chi Hang Lee +2 more
doaj +1 more source
Prognostic relevance of Centromere protein H expression in esophageal carcinoma
BMC Cancer, 2008 Background Many kinetochore proteins have been shown to be associated with human cancers. The aim of the present study was to clarify the expression of Centromere protein H (CENP-H), one of the fundamental components of the human active kinetochore, in ...
Guo Xian-Zhi +9 more
doaj +1 more source
The quantitative architecture of centromeric chromatin
eLife, 2014 The centromere, responsible for chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin. The amount of centromeric CENP-A has direct implications for both the architecture and epigenetic inheritance of centromeres.
Dani L Bodor +9 more
doaj +1 more source
, 2019 Kinetochores are supramolecular assemblies that link centromeres to microtubules for sister chromatid segregation in mitosis. For this, the inner kinetochore CCAN/Ctf19 complex binds to centromeric chromatin containing the histone variant CENP-A, but ...
Rappsilber J +10 more
core +1 more source