Results 81 to 90 of about 113,938,265 (213)

Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease.
Glover, D.M., K. Bloom, Losada, A., Cleveland, D. W., G. J. P. L. Kops, Yanagida, Mitsuhiro, Stukenberg, P., Brinkley, B., Foltz, D, Gorbsky, G. J., McAinsh, Andrew D., Sunkel, CE, Kops, G., Yen, T., Sunkel, C., Maddox, PS, T. Hirota, K. F. Sullivan, Oegema, K., Straight, A. F., Copenhaver, Gregory P., Sullivan, K.F., Lampson, M. A., Cheeseman, Iain M, Wordeman, L., S. Westermann, Yen, TJ, Brinkley, BR, Brown, W, Stukenberg, PT, Gorbsky, G.J., Walczak, C.E., D. M. Glover, Black, B., Yen, T.J., Brown, William, Heun, P., A. F. Straight, Karpen, Gary, Allshire, Robin, Copenhaver, G.P., Scott, K.C., Sullivan, K., Walczak, CE, Sullivan, B.A., H. F. Willard, O'Neill, RJ, Warburton, P. E., Straight, A., Yanagida, M, Walczak, C., Glover, David M., Choo, K. H. Andy, Westermann, S., Scott, Kristin C., Margolis, Robert L., Walczak, Claire E., Swedlow, J.R.; id_orcid, Maddox, P.S., Masumoto, Hiroshi, Allshire, R. C., Margolis, R., Deluca, JG, Hirota, T, Fukagawa, T, Bloom, K, Margolis, RL, Oegema, K, Jansen, L.E.T., Karpen, G., Sullivan, Kevin Francis, Scott, K., Sullivan, KF, Earnshaw, Bill, Straight, AF, Fukagawa, T., A. Losada, Desai, Arshad, Earnshaw, WC, DeLuca, Jennifer G., O’Neill, R. J., P. E. Warburton, Diekmann, S., Losada, A, DeLuca, J.G., M. A. Lampson, Stukenberg, P.T., G. Karpen, Sunkel, C.E., Erhardt, S, Heun, P, S. M. Lens, B. G. Mellone, Yen, T. J., Gassmann, Reto, Jansen, LET, H. Maiato, Maddox, Paul Samuel, (47 other authors), et al, Jansen, L. E.T., Copenhaver, G. P., Harrison, S.C., K. Luger, Kops, G. J.P.L., L. E. T. Jansen, K. Oegema, Gerlich, D., Kops, GJPL, Musacchio, A., L. Wordeman, Harrison, SC, B. E. Black, Cleveland, DW, Allshire, RC, Luger, K., Margolis, R.L., Swedlow, J. R., Gerlich, DW, Cheesman, I.M., G. J. Gorbsky, Salmon, Eward D., Salmon, E., T. J. Yen, Black, B. E., Salmon, Edward D, Fitzgerald-Hayes, Molly, Straight, Aaron F., Walczak, C. E., McAinsh, A., Cheeseman, I. M., Meraldi, P, Sullivan, K. F., Diekmann, S, Willard, H. F., D. Foltz, Willard, H., Black, B.E., Wordeman, Linda, G. P. Copenhaver, J. G. DeLuca, Harrison, S., Salmon, ED, Erhardt, S., Allshire, R., Cleveland, D.W., Fitzgerald-Hayes, M., Straight, A.F., Lens, S. M., Cheeseman, IM, Lens, S.M., McAinsh, AD, W. C. Earnshaw, Westermann, S, Brinkley, B.R., Jansen, L. E. T., Lens, S., Swedlow, J., Mellone, B., Willard, HF, Glover, D., Musacchio, A, Cheeseman, Iain M., J. R. Swedlow, Cheeseman, I., Willard, H.F., Gorbsky, G., Glover, D. M., Salmon, E. D., P. Meraldi, Desai, A, Cheeseman, I.M., Kops, G. J. P. L., DeLuca, J. G., Stukenberg, P. T., Sullivan, B., Lens, SM, Gassmann, R., McAinsh, A. D., Cleveland, D., Allshire, R.C., Mellone, B.G., S. C. Harrison, Earnshaw, William C., Warburton, P.E., Mellone, BG, P. Heun, K. Yoda, C. E. Sunkel, B. A. Sullivan, Hirota, Toru, W. Brown, Margolis, R. L., Brinkley, B. R., O'Neill, R. J., Sullivan, Beth A., Stukenberg, P. Todd, Westermann, Stefan, Yoda, K., O’Neill, Rachel J., H. Masumoto, Bloom, Kerry S., Earnshaw, W.C., O`Neil, R., Choo, K., Diekmann, Stephan, Sullivan, BA, Foltz, Daniel R., Choo, K. H. A., Glover, DM, Yoda, K, Hirota, T., Cleveland, Don W., DeLuca, J., Gorbsky, GJ, Harrison, Stephen C., Gerlich, D. W., D. W. Gerlich, Choo, K. H.A., Gassmann, R, Sullivan, B. A., Jansen, L., B. R. Brinkley, Masumoto, H, Scott, KC, Gerlich, D.W., Black, Ben E., K. C. Scott, Lens, Susanne M. A., Maiato, Helder, Earnshaw, W., Warburton, PE, E. D. Salmon, Karpen, G, Mellone, B. G., Willard, Huntington F., Kops, G.J.P.L., Copenhaver, G., Choo, KHA, Warburton, Peter E., T. Fukagawa, Maiato, H., Wordeman, L, McAinsh, A.D., Erhardt, Sylvia, Yen, Tim J., Maddox, P. S., Earnshaw, W. C., Losada, Ana, Brown, W., Sunkel, C. E., S. Diekmann, M. Yanagida, R. C. Allshire, Copenhaver, GP, Mellone, Barbara G., Swedlow, Jason R., O'Neill, R.J., M. Fitzgerald-Hayes, Warburton, P., Harrison, S. C., Masumoto, H., Meraldi, Patrick, P. S. Maddox, Choo, K.H.A., Harrison, Stephen, R. Gassmann, Heun, Patrick, Desai, A., I. M. Cheeseman, Meraldi, P., K. H. A. Choo, Sunkel, Claudio E., Musacchio, Andrea, Yanagida, M., Salmon, E.D., A. Desai, Lampson, M., Lampson, M.A., Maiato, H, Jansen, Lars E. T., Black, BE, D. W. Cleveland, R. L. Margolis, Lampson, Michael A., Swedlow, JR, S. Erhardt, Maddox, P., A. D. McAinsh, Bloom, K., C. E. Walczak, Foltz, D., A. Musacchio, Luger, K, Fitzgerald-Hayes, M, Scott, K. C., R. J. O’Neill, Lampson, MA, P. T. Stukenberg, Oegema, Karen, Earnshaw, W C   +299 more
core   +1 more source

Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma

Molecular Cancer, 2010
Background Our recent cDNA microarray data showed that centromere protein F (CENP-F) is significantly upregulated in primary cultured nasopharyngeal carcinoma (NPC) tumor cells compared with normal nasopharyngeal epithelial cells.
Cao Jing-Yan, Liu Li, Chen Shu-Peng, Zhang Xing, Mi Yan-Jun, Liu Zhi-Gang, Li Man-Zhi, Zhang Hua, Qian Chao-Nan, Shao Jian-Yong, Fu Li-Wu, Xia Yun-Fei, Zeng Mu-Sheng   +12 more
doaj   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 250-276, September 2026.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source

Disulfide engineering of the FANCM–MHF complex reveals constraints on crosslink design in symmetric oligomers

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The Fanconi anemia complementation group M protein (FANCM)–MHF complex is required for branched DNA recognition in the Fanconi anemia pathway, but structural analysis of the intact complex has been hindered by dissociation of FANCM from the FANCM‐associated histone fold (MHF) heterotetramer under crystallization conditions.
Sho Ito, Tatsuya Nishino
wiley   +1 more source

CENP-F-Miro complex is necessary for normal mitochondrial spreading in human cells.

, 2019
A) Immunofluorescence of mtBFP-expressing cytokinetic CENP-FWT or CENP-FF2989A U2OS cells using a CENP-F antibody (Ab5). B) Examples of mitochondrial morphology in live CENP-FWT or CENP-FF2989A interphase U2OS cells stably expressing mtBFP.
Martin Peterka (6444656), Benoît Kornmann (260286)   +1 more
core   +1 more source

The checkpoint protein Zw10 connects CAL1-dependent CENP-A centromeric loading and mitosis duration in Drosophila cells.

PLoS Genetics, 2019
A defining feature of centromeres is the presence of the histone H3 variant CENP-A that replaces H3 in a subset of centromeric nucleosomes. In Drosophila cultured cells CENP-A deposition at centromeres takes place during the metaphase stage of the cell ...
Anne-Laure Pauleau, Andrea Bergner, Janko Kajtez, Sylvia Erhardt   +3 more
doaj   +1 more source

Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast.

PLoS Genetics, 2012
Specialized chromatin containing CENP-A nucleosomes instead of H3 nucleosomes is found at all centromeres. However, the mechanisms that specify the locations at which CENP-A chromatin is assembled remain elusive in organisms with regional, epigenetically
Eun Shik Choi, Annelie Strålfors, Sandra Catania, Araceli G Castillo, J Peter Svensson, Alison L Pidoux, Karl Ekwall, Robin C Allshire   +7 more
doaj   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, Volume 117, Issue 9, Page 2335-2344, September 2026.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

The CENP-A chaperone Scm3 becomes enriched at kinetochores in anaphase independently of CENP-A incorporation [PDF]

Cell Cycle, 2011
Centromeres are specialized chromatin domains where kinetochores assemble. Centromeres contain as a conserved feature nucleosomes that are composed of the canonical histones H2A, H2B and H4 and a centromere-specific histone H3 variant, known as CENP-A in humans and Cse4 in budding yeast. The incorporation of CENP-A homologues into centromeric chromatin
Lucia, Luconi, Yasuhiro, Araki, Sarah, Erlemann, Elmar, Schiebel   +3 more
openaire   +2 more sources

CENP-A^Cse4 mislocalizes to regions that are enriched for the histone variant H2A.Z^Htz1.

, 2016
(A) Mean CENP-ACse4 ChIP coverage for the 3Flag-CSE4 (SBY10419, blue), psh1Δ 3Flag-CSE4 (SBY10484, pink), pGAL-3Flag-CSE4 (SBY10425, green) and psh1Δ pGAL-3Flag-CSE4 (SBY10483, orange) strains centered on annotated NDRs [65].
Sue Biggins (280260), Erica M. Hildebrand (3178719)   +1 more
core   +1 more source