Results 61 to 70 of about 113,938,265 (213)

CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions

Cell Reports, 2016
The presence of chromatin containing the histone H3 variant CENP-A dictates the location of the centromere in a DNA sequence-independent manner. But the mechanism by which centromere inheritance occurs is largely unknown. We previously reported that CENP-
Yohei Niikura, Risa Kitagawa, Katsumi Kitagawa   +2 more
doaj   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
Sullivan, Beth A., Sullivan, Beth A, Karen E. Hayden, Kaitlin M. Stimpson, Beth A Sullivan, Bridger Joanna M., Song, IY, Sullivan, BA, Ihn Young Song, Beth A. Sullivan, Karen E Hayden, Hayden, Karen E., Jauch, A, Bridger, Joanna M., Joanna M Bridger, Joanna M. Bridger, Hayden, Karen E, Song Ihn Young, Jauch, Anna, Holtgreve-Grez, Heidi, Heidi Holtgreve-Grez, Holtgreve-Grez Heidi, Stimpson, Kaitlin M, Stimpson, KM, Kaitlin M Stimpson, Anna Jauch, Bridger, JM, Jauch Anna, Bridger, Joanna M, Stimpson Kaitlin M., Sullivan Beth A., Song, Ihn Young, Hayden Karen E., Hayden, KE, Holtgreve-Grez, H, Stimpson, Kaitlin M.   +35 more
core   +2 more sources

GFP-CENP-C, CID-GFP or CAL1-GFP in early prophase oocytes.

, 2023
A) Localization of GFP-CID (green) and centromeres detected using a CENP-C antibody (red). B) Localization of GFP-CAL1 (green) with the centromeres detected using a CID antibody (red).
Aashka Parikh (17481074), Manisha Persaud (17481068), Hannah Sturm (17481071), Jessica E. Fellmeth (17481065), Kim S. McKim (17481077), Neha Changela (848353), Janet K. Jang (4918498)   +6 more
core   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition

Nature Communications, 2017
Centromere maintenance depends on the persistence of the histone variant CENP-A at the centromeres. Here, the authors characterize the core centromeric nucleosome complex wherein CENP-C confers a stable CENP-A nucleosome conformation and CENP-N fastens ...
Lucie Y. Guo, Praveen Kumar Allu, Levani Zandarashvili, Kara L. McKinley, Nikolina Sekulic, Jennine M. Dawicki-McKenna, Daniele Fachinetti, Glennis A. Logsdon, Ryan M. Jamiolkowski, Don W. Cleveland, Iain M. Cheeseman, Ben E. Black   +11 more
doaj   +1 more source

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

CENP-A^Cse4 mislocalization to promoters alters transcription.

, 2016
(A) Graph of the number of transcripts significantly increased or decreased compared to the WT strain by RNA-seq of psh1Δ and htz1Δ cells at t = 2 hours. Differential expression analysis statistics were performed using edgeR [78]. (B) Graph of the number
Sue Biggins (280260), Erica M. Hildebrand (3178719)   +1 more
core   +1 more source

CENP-C is required for centromere pairing and clustering.

, 2023
A) FISH probes were used to detect the pericentromeric regions of chromosome 2 (red), and X (magenta) in the germarium of GL00409/NGTA (referred to as Cenp-CRNAi) or control oocytes. DNA is in blue.
Aashka Parikh (17481074), Manisha Persaud (17481068), Hannah Sturm (17481071), Jessica E. Fellmeth (17481065), Kim S. McKim (17481077), Neha Changela (848353), Janet K. Jang (4918498)   +6 more
core   +1 more source

Quantitative single-molecule microscopy reveals that CENP-ACnp1 deposition occurs during G2 in fission yeast [PDF]

Open Biology, 2012
The inheritance of the histone H3 variant CENP-A in nucleosomes at centromeres following DNA replication is mediated by an epigenetic mechanism. To understand the process of epigenetic inheritance, or propagation of histones and histone variants, as ...
David Lando, Ulrike Endesfelder, Harald Berger, Lakxmi Subramanian, Paul D. Dunne, James McColl, David Klenerman, Antony M. Carr, Markus Sauer, Robin C. Allshire, Mike Heilemann, Ernest D. Laue   +11 more
doaj   +1 more source