Results 71 to 80 of about 113,938,265 (213)

Single‐Nucleus Transcriptome Analysis Provides New Insights Into B Chromosome Elimination in Sorghum

Plant Biotechnology Journal, EarlyView.
ABSTRACT B chromosomes are supernumerary entities found in many plant species, with some exhibiting tissue‐specific elimination. In Sorghum purpureosericeum, extensive B chromosome elimination occurs during embryogenesis affecting most of the embryonic organs, leaving the B chromosome maintained mainly in limited regions of meristems.
T. Bojdová, P. Abaffy, L. Valihrach, M. Karafiátová, J. Bartoš   +4 more
wiley   +1 more source

The Split Personality of CENP-A Nucleosomes [PDF]

Cell, 2012
The composition and structure of centromeric nucleosomes, which contain the histone H3 variant CENP-A, is intensely debated. Two independent studies in this issue, in yeast and human cells, now suggest that CENP-A nucleosomes adopt different structures depending on the stage of the cell cycle.
Westhorpe, Frederick G., Straight, Aaron F.   +1 more
openaire   +2 more sources

CENP-A occupies DNA sequences within putative centromere contigs.

, 2019
Organization of each CENP-A-enriched island corresponding to centromere candidates: (A) CenX, (B) Cen4; (C) CenY; (D) Cen3; (E) Cen2. Different repeat families are color coded (see legend; note that Jockey elements are shown in one color even though they
Chao-Ting Wu (6697064), Xiaolu Wei (3204066), Amanda M. Larracuente (3258891), Brian J. Beliveau (499927), Ankita Chavan (6697055), Nuno M. C. Martins (6157628), Jelena Erceg (505032), Bryce Santinello (6697061), Ching-Ho Chang (664410), Jason Palladino (6697058), Chin-Chi Chen (134251), Barbara G. Mellone (134260)   +11 more
core   +1 more source

Mechanistic and functional insights into the human kinesin motor CENP-E in cell division

, 2022
During mitosis, chromosomes align at the spindle equator and biorient in order to equally distribute the genome into two daughter cells. A macromolecular protein complex, known as the kinetochore, facilitates the end-on attachment of chromosomes to
Craske, Benjamin Harry
core   +1 more source

CENP-A nucleosomes are interspersed at variable densities throughout the core centromeric domain

, 2011
The 87.8 kilobase (kb) major domain. Shown are the putative subdomains of centromere protein (CENP)-A, with higher densities indicated by darker shading. The polymerase chain reaction (PCR) microarray fragments are shown below (see Figure 2).
György Abrusan (45376), Kinya Yoda (45378), Andreas G Ladurner (45379), Björn Fritz (45374), Alicia Alonso (45373), Dan Hasson (45375), Fanny Cheung (45377), Bernhard Radlwimmer (30197), Peter E Warburton (45380)   +8 more
core   +1 more source

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

Advanced Science, Volume 13, Issue 51, 14 September 2026.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li, Chun‐Hui Zhang, Yong Wang, Cheng‐Yuan Li, Da‐Rong Wen, Xi Xia, Liang Zhou, Wei‐Ping Qian, Qing‐Yuan Sun, Chang‐Zhong Li   +9 more
wiley   +1 more source

CENP-B: Cornerstone of Kinetochores in Centromeres of Human Chromosomes

Frontiers in Bioscience-Landmark
Each chromosome contains a centromere, the site at which the kinetochore assembles to ensure accurate chromosome segregation during cell division. Centromeric chromatin, which anchors the kinetochore, includes three core proteins: Centromere Protein A ...
Fritz F. Parl
doaj   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

CENP-A Mislocalization requires the H3.3 chaperones HIRA and DAXX.

, 2018
A. Schematic of the definition of replicated peak sets and the calculation of ectopic CENP-A peak coverage. B. Bar chart showing the peak coverage, in kilobases, of replicated ectopic CENP-A peaks from 3 replicate ChIP-seq experiments after 72-hour ...
David Sturgill (15686), Rajbir Athwal (535504), Yamini Dalal (33140), Jonathan Nye (696479)   +3 more
core   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source