Results 31 to 40 of about 113,938,265 (213)
CENP-C is required for kinetochore assembly and chromosome segregation.
, 2023 Immunocytology was performed on GL00409 / mata stage 14 oocytes (referred to as Cenp-CRNAi) or a Cenp-C mutant (Cenp-CZ3-4375/Cenp-CIR35 referred to as “Cenp-CZ”).
Aashka Parikh (17481074) +6 more
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The pseudo GTPase CENP-M drives human kinetochore assembly
eLife, 2014 Kinetochores, multi-subunit complexes that assemble at the interface with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes during cell division.
Federica Basilico +17 more
doaj +1 more source
Molecular basis of CENP-C association with the CENP-A nucleosome at yeast centromeres [PDF]
Genes & Development, 2017 Histone CENP-A-containing nucleosomes play an important role in nucleating kinetochores at centromeres for chromosome segregation. However, the molecular mechanisms by which CENP-A nucleosomes engage with kinetochore proteins are not well understood.
Xiao, Hua +11 more
openaire +2 more sources
Molecular basis of outer kinetochore assembly on CENP-T
eLife, 2016 Stable kinetochore-microtubule attachment is essential for cell division. It requires recruitment of outer kinetochore microtubule binders by centromere proteins C and T (CENP-C and CENP-T).
Pim J Huis in 't Veld +8 more
doaj +1 more source
Clinical and Molecular Features of Anti-CENP-B Autoantibodies
Journal of Molecular Pathology, 2021 Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during mitosis.
Rahul M. Prasad +2 more
doaj +1 more source
Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways [PDF]
Journal of Cell Science, 2014 A key step of mitosis is the congression of chromosomes to the spindle equator. Congression is driven by at least two distinct mechanisms: (1) kinetochores slide along the microtubule lattice using the plus-end directed CENP-E motor, and (2) kinetochores biorientating near the pole move to the equator through microtubule depolymerisation-coupled ...
Bancroft, James M. +3 more
openaire +3 more sources
F1000Research, 2016 The centromeric protein CENP-C is a base component of the kinetochore. This protein, along with CENP-A has been shown to adaptively evolve in a number of animal and plant species.
Leos Kral
doaj +1 more source
ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth. [PDF]
PLoS ONE, 2011 BACKGROUND: Centromere protein A (CENP-A) plays important roles in cell-cycle regulation and genetic stability. Herein, we aimed to investigate its expression pattern, clinical significance, and biological function in hepatocellular carcinoma (HCC ...
Yongmei Li +9 more
doaj +1 more source
Loading of HA-CENP-C during oocyte meiotic prophase.
, 2023 In all images, HA-CENP-C is green, the centromeres are marked with CID (red), and DNA is in blue. The scale bars represent 5 μm. A) Whole germarium with HA-tagged CENP-C expressed using NGTA or matα. ORB (white) is enriched in the oocyte.
Aashka Parikh (17481074) +6 more
core +1 more source
Analysis of the sequence features contributing to centromere organisation and CENP-A positioning and incorporation [PDF]
, 2015 Centromere identity is integral for proper kinetochore formation and chromosome segregation. In most species chromosomes have a centromere at a defined locus that is propagated across generations. The histone H3 variant CENP -A acts as an epigenetic mark
Toda, Nicholas Rafael Tetsuo
core +3 more sources