Results 21 to 30 of about 113,938,265 (213)
Frontiers in Cell and Developmental Biology, 2022 In mammals, CENP-A, a histone H3 variant found in the centromeric chromatin, is critical for faithful chromosome segregation and genome integrity maintenance through cell divisions. Specifically, it has dual functions, enabling to define epigenetically the centromere position and providing the foundation for building up the kinetochore.
Renaud-Pageot, Charlène +3 more
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Stable complex formation of CENP-B with the CENP-A nucleosome [PDF]
Nucleic Acids Research, 2015 CENP-A and CENP-B are major components of centromeric chromatin. CENP-A is the histone H3 variant, which forms the centromere-specific nucleosome. CENP-B specifically binds to the CENP-B box DNA sequence on the centromere-specific repetitive DNA. In the present study, we found that the CENP-A nucleosome more stably retains human CENP-B than the H3.1 ...
Fujita, Risa +11 more
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Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes [PDF]
Human Molecular Genetics, 2000 Centromere and kinetochore proteins have a pivotal role in centromere structure, kinetochore formation and sister chromatid separation. However, the molecular architecture and the precise dynamic function of the centromere-kinetochore complex during mitosis remain poorly understood.
N, Sugata +8 more
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Reconstitution of an active human CENP-E motor
Open Biology, 2022 CENP-E is a large kinesin motor protein which plays pivotal roles in mitosis by facilitating chromosome capture and alignment, and promoting microtubule flux in the spindle.
Benjamin Craske +2 more
doaj +1 more source
Molecular & Cellular Oncology, 2017 Proper chromosome segregation relies on a functional centromere-kinetochore interface. We showed that chromatin containing CENtromere Protein A (CENP-A) is essential for centromere assembly, but dispensable for chromosome segregation in the presence of CENP-B-bound DNA sequences. This demonstrates the existence of two contact points between the DNA and
S. Hoffmann, D. Fachinetti
openaire +3 more sources
A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle [PDF]
Open Biology, 2014 The functional identity of centromeres arises from a set of specific nucleoprotein particle subunits of the centromeric chromatin fibre. These include CENP-A and histone H3 nucleosomes and a novel nucleosome-like complex of CENPs -T, -W, -S and -X ...
Carsten Dornblut +11 more
doaj +1 more source
Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres [PDF]
Genome Biology, 2007 Abstract Background Mammalian centromere formation is dependent on chromatin that contains centromere protein (CENP)-A, which is the centromere-specific histone H3 variant. Human neocentromeres have acquired CENP-A chromatin epigenetically in ectopic chromosomal locations on low-copy complex DNA ...
Alonso, Alicia +8 more
openaire +2 more sources
Relaciones Públicas y Desarrollo Local: gestión de actividades y proyectos turísticos en A Coruña
Obra Digital, 2017 Galicia es una Comunidad Autónoma con grandes recursos turísticos endógenos donde, la provincia de A Coruña se muestra como un territorio turístico relevante.
Antonia Pérez-García
doaj +1 more source
Decoding the centromeric nucleosome through CENP-N
eLife, 2017 Centromere protein (CENP) A, a histone H3 variant, is a key epigenetic determinant of chromosome domains known as centromeres. Centromeres nucleate kinetochores, multi-subunit complexes that capture spindle microtubules to promote chromosome segregation ...
Satyakrishna Pentakota +9 more
doaj +1 more source
CENP-C is exchanged at the centromeres during meiotic prophase.
, 2023 Immunocytology was performed on oocytes ubiquitously expressing GFP-CENP-C (green), plus or minus GL00409 (Cenp-CRNAi), and HA-CENP-C (red) using the mata promoter. All scale bars represent 5 μm and DNA is blue. A) GL00409 recognizes a sequence in the 5’
Aashka Parikh (17481074) +6 more
core +1 more source