Results 41 to 50 of about 3,373 (167)

Telecological Collapse: The Inevitability of Climate Breakdown in the Transmedial Podcast Drama Forest 404

Future Humanities, Volume 4, Issue 1, May 2026.
ABSTRACT This paper presents a close‐hearing analysis of Forest 404, a transmedial audio drama that was released to BBC Sounds in 2019. Despite the drama's eco‐dystopian critique of teleological ‘progress’ narratives (that enable and perpetuate the destruction of the natural world), I argue that the series ultimately propagates a sense of inevitability
Matilda Jones
wiley   +1 more source

Why we age

Biological Reviews, Volume 101, Issue 2, Page 911-925, April 2026.
ABSTRACT Three categories of explanations exist for why we age: mechanistic theories, which omit reference to evolutionary forces; weakening force of selection theories, which posit that barriers exist that prevent evolutionary forces from optimising fitness in ageing; and optimisation theories, which posit that evolutionary forces actually select for ...
Michael S. Ringel
wiley   +1 more source

Characterisation of bacteria‐induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease

The Journal of Pathology, Volume 268, Issue 4, Page 493-511, April 2026.
Abstract Enteropathogenic bacteria are a major cause of morbidity and mortality globally. While mouse models have been indispensable in advancing our understanding of infectious enteric diseases, key differences in intestinal microbiota and immunobiology between mice and humans underscore the need for alternative mammalian models that better ...
Daniel W. Hart, Aik Seng Ng, Patrycja Gazińska, Robert Goldin, Purva Gopal, Nicolize O'Dell, Ahmad Zargar, Lior Pytowski, Shamir Montazid, Chiara Bardella, James E. East, Ian P. Tomlinson, Nadine Koch, Nigel C. Bennett, Shazia Irshad   +14 more
wiley   +1 more source

Bile acids are associated with baseline and longitudinal amyloid and tau pathology in patients with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Alzheimer's disease (AD), a neurodegenerative disease, involves early alterations in the gut microbiota. Bile acids (BAs), which are metabolites produced by the microbiota, may impact brain function through the gut‐brain axis. METHODS By reference to multimodal datasets from the Chinese Preclinical Alzheimer's Disease Study (n ...
Wenjie Fu, Xiaowen Chao, Ying Wang, Shu Liu, Jie Wang, Qi Huang, Ying Luan, Peiyang Luo, Yihui Guan, Yingren Mai, Wei Jia, the Alzheimer's Disease Neuroimaging Initiative, Qihao Guo, Tianlu Chen, Xiaowei Ma, Fang Xie   +15 more
wiley   +1 more source

Centenarians in Europe [PDF]

Maturitas, 2017
The group of individuals aged 80 and over is growing faster than other segments of the population, and within this group the number of centenarians has risen exponentially worldwide. This paper reports the numbers of centenarians (total, and ratio relative to total population) in 32 European countries and their key characteristics: gender distribution,
Teixeira, L., Araújo, L., Jopp, D., Ribeiro, O.   +3 more
openaire   +4 more sources

Clonal haematopoiesis in chronic lymphocytic leukaemia: Biology, inflammaging and clinical implications in the era of targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
In an ageing and inflamed haematopoietic ecosystem, clonal haematopoiesis and chronic lymphocytic leukaemia may originate from shared or parallel stem cell clones. This interaction modulates the effects of targeted therapies and contributes to cytopenias, cardiovascular toxicity, therapy‐related myeloid neoplasms and Richter transformation.
Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Sex hormones and physical function among the Chinese oldest-old and centenarian women

Journal of Translational Medicine, 2022
Background Physical independence is crucial for overall health in the elderly individuals. The life expectancy of women has been shown to be higher than that of men, which is also known as the “male–female health-survival paradox”.
Qiao Zhu, Ping Ping, Pei Zhang, Chaoxue Ning, Yali Zhao, Yao Yao, Xiubing Li, Shihui Fu   +7 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Whole genome sequences of a male and female supercentenarian, ages greater than 114 years

Frontiers in Genetics, 2012
Supercentenarians (age 110+ years old) generally delay or escape age-related diseases and disability well beyond the age one hundred and this exceptional survival is likely to be influenced by a genetic predisposition that includes both common and rare ...
Paola eSebastiani, Alberto eRiva, Monty eMontano, Phillip ePham, Ali eTorkamani, Eugene eScherba, Gary eBenson, Jacqueline N Milton, Clinton T Baldwin, Stacy eAndersen, Nicholas J Schork, Martin H Steinberg, Thomas T Perls   +12 more
doaj   +1 more source

Select Small Non‐Coding RNAs Are Determinants of Survival in Older Adults

Aging Cell, Volume 25, Issue 3, March 2026.
Circulating small RNAs were profiled by RNA sequencing in a well‐characterized cohort and evaluated alongside 187 clinical variables to predict survival. Models incorporating circulating small RNAs, including parsimonious subsets, outperformed age and clinical factors alone (AUC), with causal analyses supported by experimental evidence from the ...
Virginia Byers Kraus, Sisi Ma, Syeda Iffat Naz, Xin Zhang, Christopher G. Vann, Melissa C. Orenduff, William E. Kraus, Steven Shen, Janet L. Huebner, Ching‐Heng Chou, Erich Kummerfeld, Harvey Jay Cohen, Constantin F. Aliferis   +12 more
wiley   +1 more source