Results 51 to 60 of about 3,373 (167)

A Cross-Sectional Study of Compositional and Functional Profiles of Gut Microbiota in Sardinian Centenarians

open access: yesmSystems, 2019
Sardinia, Italy, has a high prevalence of residents who live more than 100 years. The reasons for longevity in this isolated region are currently unknown. Gut microbiota may hold a clue.
Lu Wu   +5 more
doaj   +1 more source

Masticatory Function in Elderly Individuals Living in Long‐Term Care Facilities in Brazil: Associations Between Objective and Subjective Measurements

open access: yesJournal of Oral Rehabilitation, Volume 53, Issue 3, Page 761-769, March 2026.
Objective and subjective masticatory functions were associated, but their related factors differed, highlighting the importance of considering both objective and self‐perceived indicators when assessing masticatory dysfunction in LTCF residents.
Lorena Tavares Gama   +4 more
wiley   +1 more source

Adipokines and Aging: Findings From Centenarians and the Very Old

open access: yesFrontiers in Endocrinology, 2019
Adipose tissue, which was once considered as a simple energy storage depot, is now recognized as an active endocrine organ that regulates the whole-body energy homeostasis by secreting hundreds of bioactive substances termed adipokines.
Yasumichi Arai   +2 more
doaj   +1 more source

Endovascular abdominal aortic aneurysm repair in a centenarian

open access: yesJournal of Vascular Surgery Cases and Innovative Techniques, 2020
As the general population ages, there will be an increasing number of vascular patients in their 90s and older. However, geriatric patients have historically been turned down for abdominal aortic aneurysm repair despite high aneurysm-related mortality in
Kirthi S. Bellamkonda, MSc   +4 more
doaj   +1 more source

How well can centenarians hear? [PDF]

open access: yesPLoS ONE, 2013
With advancements in modern medicine and significant improvements in life conditions in the past four decades, the elderly population is rapidly expanding. There is a growing number of those aged 100 years and older.
Zhongping Mao   +5 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, Volume 600, Issue 4, Page 392-417, February 2026.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity

open access: yesAGING MEDICINE, Volume 9, Issue 1, Page 67-81, February 2026.
Investigating centenarians who exemplify healthy longevity can aid in formulating preventive strategies aimed at achieving health and extending lifespan in the context of population aging. Hainan longevity model (HLM) plays key roles in promoting healthy longevity and provides scientific evidence for achieving healthy longevity in the older population.
Shihui Fu   +15 more
wiley   +1 more source

From consortia discovery to biotech creation: An innovative approach to next‐gen Alzheimer's drugs

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) research has entered a new era where public‐private partnerships are reigniting the pursuit of disease‐modifying therapies targeting mechanisms beyond amyloid and tau. This perspective outlines how Monument Biosciences was founded to advance novel therapies by translating National Institutes of Health (NIH) ‐supported ...
Sarah F. Giardina   +11 more
wiley   +1 more source

Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging

open access: yesHuman Genomics, 2020
Background Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research.
Shuhua Shen   +7 more
doaj   +1 more source

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