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Central Nervous System Viral Diseases [PDF]
Encyclopedia of Virology, 2008 The nervous system has multiple intrinsic defenses against viral infection, including the blood–brain barrier. Yet, the postmitotic nature of neurons creates a uniquely vulnerable environment susceptible to irreversible damage. Various viruses can infect the different cell types within the central nervous system, neurons, oligodendrocytes, astrocytes ...
Johnson, R.T., Greenberg, B.M.
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Viral diseases of the central nervous system [PDF]
Current Opinion in Virology, 2015 Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. The complexity of these diseases is influenced by the sheer number of different neurotropic viruses, the diverse routes of CNS entry, viral tropism, and the immune system.
Phillip A, Swanson, Dorian B, McGavern
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Imaging of central nervous system viral diseases [PDF]
Journal of Magnetic Resonance Imaging, 2012 AbstractViral infections of the central nervous system (CNS) are commonly encountered and there has been continued emergence of new neurotropic viruses which are being frequently recognized. These may present clinically as encephalitis, meningitis, encephalomyelitis, and encephalomyeloradiculitis. The clinical manifestations are usually nonspecific and
Rakesh Kumar, Gupta +3 more
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Microbiology Spectrum, 2021 Viral diseases of the central nervous system (CNS) represent a major global health concern. Difficulties in treating these diseases are caused mainly by the biological tissues and barriers, which hinder the transport of drugs into the CNS.
Song Zhu +6 more
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Frontiers in Immunology, 2022 Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-stimulated genes (ISGs) through intracellular signaling cascades.
Rui Lang +14 more
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Molecular analysis of cerebrospinal fluid in viral diseases of the central nervous system
Journal of Clinical Virology, 2003 The use of nucleic acid (NA) amplification techniques has transformed the diagnosis of viral infections of the central nervous system (CNS). Because of their enhanced sensitivity, these methods enable detection of even low amounts of viral genomes in cerebrospinal fluid. Following more than 10 years of experience, the polymerase chain reaction or other
Cinque, Paola +2 more
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Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease [PDF]
The Journal of Experimental Medicine, 1996 One hypothesis for the etiology of central nervous system (CNS) autoimmune disease is that infection by a virus sharing antigenic epitopes with CNS antigens (molecular mimicry) elicits a virus-specific immune response that also recognizes self-epitopes.
C F, Evans +3 more
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VirusesTripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity.
Adam Hage, Mikhaila Janes, Sonja M. Best
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Revista da Sociedade Brasileira de Medicina Tropical, 2021 INTRODUCTION: Herpesviruses, enteroviruses, and arboviruses are important because of their clinical relevance and ability to cause meningitis, encephalitis, meningoencephalitis, and other diseases.
Lucas Lopes Leon +6 more
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A neuron-specific antiviral mechanism prevents lethal flaviviral infection of mosquitoes. [PDF]
PLoS Pathogens, 2015 Mosquitoes are natural vectors for many etiologic agents of human viral diseases. Mosquito-borne flaviviruses can persistently infect the mosquito central nervous system without causing dramatic pathology or influencing the mosquito behavior and lifespan.
Xiaoping Xiao +5 more
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