Results 101 to 110 of about 1,358,589 (334)
Systemic TLR2 tolerance enhances central nervous system remyelination
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko +9 more
doaj +1 more source
The Elimination of the Sexual Exploitation of Children: Two Policy Briefings [PDF]
, 2012 The Oak Foundation child-abuse programme has funded and supported a range of civil society actors over the course of the last ten years, with the aim of reducing the incidence of the sexual exploitation of children, focusing primarily on work in East ...
core
Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance [PDF]
, 2013 Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of ...
Atkinson, Nigel S. +5 more
core +3 more sources
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Hemodynamic studies of the legs under weightlessness [PDF]
Following exposure to weightlessness, alterations in the return of blood from the legs play a crucial role in orthostatic tolerance and may be an important factor in work tolerance.
Hoffler, G. W., Thornton, W. E.
core +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Immunological mechanisms of tolerance: Central, peripheral and the role of T and B cells
, 2023 Xun Meng +5 more
openalex +1 more source
Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System [PDF]
, 2022 Sweta Adhikary, John T. Williams
openalex +1 more source
Central tolerance: Essential for preventing autoimmune disease? [PDF]
European Journal of Immunology, 2009 AbstractRecessive central tolerance of developing T cells is caused by antigen‐induced deletion of immature cortical double positive and medullary single positive thymocytes in the absence of TCR editing. There are few examples where it can be convincingly shown that recessive tolerance plays an essential role in preventing autoimmune disease.
openaire +2 more sources
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source