Results 1 to 10 of about 27,287 (301)
A novel atypical sperm centriole is functional during human fertilization
Nature Communications, 2018 The two zygote centrioles are paternally inherited; however, their development is incompletely understood. Here, the authors show that the distal centriole is remodeled into an atypical centriole which functions as the zygote’s second centriole.
Emily L Fishman +2 more
exaly +3 more sources
PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
eLife, 2022 Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro +5 more
doaj +2 more sources
Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells
eLife, 2021 How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni +5 more
doaj +2 more sources
Mechanism and Regulation of Centriole and Cilium Biogenesis
Annual Review of Biochemistry, 2019 The centriole is an ancient microtubule-based organelle with a conserved nine-fold symmetry. Centrioles form the core of centrosomes, which organize the interphase microtubule cytoskeleton of most animal cells and form the poles of the mitotic spindle ...
David K Breslow, Andrew J Holland
exaly +2 more sources
A helical inner scaffold provides a structural basis for centriole cohesion
Science Advances, 2020 The centriole has a helical inner scaffold that imparts microtubule triplet cohesion and centriole geometry. The ninefold radial arrangement of microtubule triplets (MTTs) is the hallmark of the centriole, a conserved organelle crucial for the formation ...
Maeva Le Guennec +2 more
exaly +2 more sources
eLife, 2019 Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer +1 more
doaj +2 more sources
Nature Communications, 2018 Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate.
Weng Man Chong +2 more
exaly +2 more sources
Nature Communications, 2019 Centrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole’s distal appendages.
Dong Kong +2 more
exaly +2 more sources
Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
Nature Communications, 2019 Replication stress, a hallmark of cancerous and pre-cancerous lesions, is linked to structural chromosomal aberrations. Recent studies demonstrated that it could also lead to numerical chromosomal instability (CIN).
Therese Wilhelm +2 more
exaly +2 more sources
Conserved molecular interactions in centriole-to-centrosome conversion [PDF]
Nature Cell Biology, 2015 Centrioles are required to assemble centrosomes for cell division and cilia for motility and signalling. New centrioles assemble perpendicularly to pre-existing ones in G1-S and elongate throughout S and G2.
Jingyan Fu +2 more
exaly +4 more sources