Results 1 to 10 of about 18,770 (220)

C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly [PDF]

Nature Communications
Centrioles play key roles in mitotic spindle assembly. Once assembled, centrioles exhibit long-term stability, but how stability is achieved and how it is regulated are not completely understood.
Jason A. Pfister, Lorenzo Agostini, Lorène Bournonville, Aurélien Perrier, Prabhu Sankaralingam, Zachary G. Bell, Virginie Hamel, Paul Guichard, Christian Biertümpfel, Naoko Mizuno, Kevin F. O’Connell   +10 more
doaj   +2 more sources

A novel atypical sperm centriole is functional during human fertilization

Nature Communications, 2018
The two zygote centrioles are paternally inherited; however, their development is incompletely understood. Here, the authors show that the distal centriole is remodeled into an atypical centriole which functions as the zygote’s second centriole.
Emily L Fishman, Quynh P H Nguyen, Dong Kong   +2 more
exaly   +2 more sources

Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex [PDF]

Cell Structure and Function
For the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kinesin-II motors.
Koshi Tasaki, Yohei Katoh, Hye-Won Shin, Kazuhisa Nakayama   +3 more
doaj   +2 more sources

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

eLife, 2022
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland   +5 more
doaj   +1 more source

Experimental and Natural Induction of de novo Centriole Formation

Frontiers in Cell and Developmental Biology, 2022
In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Kasuga Takumi, Daiju Kitagawa
doaj   +1 more source

Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells

eLife, 2021
How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni, Jonathan Marquez, Priya Date, Rosa Ventrella, Brian J Mitchell, Mustafa K Khokha   +5 more
doaj   +1 more source

CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]

PLoS ONE, 2011
BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck, Emilie Montembault, Pierre Romé, Aude Pascal, Jean-Yves Cremet, Régis Giet   +5 more
doaj   +1 more source

Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase.

PLoS ONE, 2015
A procentriole is assembled next to the mother centriole during S phase and remains associated until M phase. After functioning as a spindle pole during mitosis, the mother centriole and procentriole are separated at the end of mitosis.
Mi Young Seo, Wonyul Jang, Kunsoo Rhee
doaj   +1 more source

Functional Analysis of Hydrolethalus Syndrome Protein HYLS1 in Ciliogenesis and Spermatogenesis in Drosophila

Frontiers in Cell and Developmental Biology, 2020
Cilia and flagella are conserved subcellular organelles, which arise from centrioles and play critical roles in development and reproduction of eukaryotes. Dysfunction of cilia leads to life-threatening ciliopathies.
Yanan Hou, Zhimao Wu, Zhimao Wu, Zhimao Wu, Yingying Zhang, Yingying Zhang, Yingying Zhang, Huicheng Chen, Huicheng Chen, Huicheng Chen, Jinghua Hu, Yi Guo, Ying Peng, Ying Peng, Qing Wei   +14 more
doaj   +1 more source

Atypical centrioles are present in Tribolium sperm [PDF]

Open Biology, 2017
Typical centrioles are made of microtubules organized in ninefold symmetry. Most animal somatic cells have two centrioles for normal cell division and function.
E. L. Fishman, Kyoung Jo, Andrew Ha, Rachel Royfman, Ashtyn Zinn, Malathi Krishnamurthy, Tomer Avidor-Reiss   +6 more
doaj   +1 more source