Cells, 2018 Centrioles are ancient subcellular protein-based organelles that maintain a conserved number and structure across many groups of eukaryotes. Centriole number (two per cells) is tightly regulated; each pre-existing centriole nucleates only one centriole ...
Tomer Avidor-Reiss
exaly +3 more sources
An interaction network of inner centriole proteins organised by POC1A-POC1B heterodimer crosslinks ensures centriolar integrity [PDF]
Nature CommunicationsCentriole integrity, vital for cilia formation and chromosome segregation, is crucial for human health. The inner scaffold within the centriole lumen composed of the proteins POC1B, POC5 and FAM161A is key to this integrity.
Cornelia Sala +7 more
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C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly [PDF]
Nature CommunicationsCentrioles play key roles in mitotic spindle assembly. Once assembled, centrioles exhibit long-term stability, but how stability is achieved and how it is regulated are not completely understood.
Jason A. Pfister +10 more
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Centrobin serves as a safeguard to guide timely centriole maturation during the cell cycle [PDF]
Scientific ReportsCentrioles assemble and segregate in link to the cell cycle. Daughter centrioles assemble at S phase, and become young mother centrioles after M phase. Since distal appendages (DAs) are installed to young mother centrioles at the second G2/M transition ...
Dohyong Lee +6 more
doaj +2 more sources
PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
eLife, 2022 Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro +5 more
doaj +1 more source
Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase. [PDF]
PLoS ONE, 2015 A procentriole is assembled next to the mother centriole during S phase and remains associated until M phase. After functioning as a spindle pole during mitosis, the mother centriole and procentriole are separated at the end of mitosis.
Mi Young Seo, Wonyul Jang, Kunsoo Rhee
doaj +1 more source
Experimental and Natural Induction of de novo Centriole Formation
Frontiers in Cell and Developmental Biology, 2022 In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Kasuga Takumi, Daiju Kitagawa
doaj +1 more source
CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]
PLoS ONE, 2011 BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck +5 more
doaj +1 more source
Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells
eLife, 2021 How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Cilia and flagella are conserved subcellular organelles, which arise from centrioles and play critical roles in development and reproduction of eukaryotes. Dysfunction of cilia leads to life-threatening ciliopathies.
Yanan Hou +14 more
doaj +1 more source