Results 111 to 120 of about 27,287 (301)
The Cep57-pericentrin module organizes PCM expansion and centriole engagement
Nature Communications, 2019 Centriole duplication occurs once per cell cycle to ensure robust formation of bipolar spindles and chromosome segregation. Each newly-formed daughter centriole remains connected to its mother centriole until late mitosis.
Koki Watanabe +4 more
semanticscholar +1 more source
Plk4 triggers autonomous de novo centriole biogenesis and maturation
bioRxiv, 2020 Centrioles form centrosomes and cilia. In most proliferating cells, centrioles assemble through canonical duplication, which is spatially, temporally and numerically regulated by the cell cycle and the presence of mature centrioles.
C. Nabais +8 more
semanticscholar +1 more source
Towards understanding centriole elimination
Open Biology, 2023 Centrioles are microtubule-based structures crucial for forming flagella, cilia and centrosomes. Through these roles, centrioles are critical notably for proper cell motility, signalling and division. Recent years have advanced significantly our understanding of the mechanisms governing centriole assembly and architecture.
Nils Kalbfuss, Pierre Gönczy
openaire +3 more sources
Andrology, EarlyView.ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu +2 more
wiley +1 more source
Nature CommunicationsCentriole integrity, vital for cilia formation and chromosome segregation, is crucial for human health. The inner scaffold within the centriole lumen composed of the proteins POC1B, POC5 and FAM161A is key to this integrity.
Cornelia Sala +7 more
doaj +1 more source
Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells
eLifeSAS-6 (SASS6) is essential for centriole formation in human cells and other organisms but its functions in the mouse are unclear. Here, we report that Sass6-mutant mouse embryos lack centrioles, activate the mitotic surveillance cell death pathway, and ...
Marta Grzonka, Hisham Bazzi
doaj +1 more source
The importance of a single primary cilium [PDF]
, 2013 The centrosome is the main microtubule-organizing center in animal cells, and helps to influence the morphology of the microtubule cytoskeleton in interphase and mitosis. The centrosome also templates the assembly of the primary cilium, and together they
Mahjoub, Moe R
core +2 more sources
Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development
bioRxiv, 2020 Centrosomes, composed of two centrioles and pericentriolar material, organize mitotic spindles during cell division and template cilia during interphase.
Cally Xiao +5 more
semanticscholar +1 more source
Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice
Andrology, EarlyView.ABSTRACT Background Sperm motility is essential for male fertility, and its regulation is dependent on the structural integrity of the axoneme. The axoneme consists of a conserved “9+2” microtubule arrangement and is supported by microtubule inner proteins. However, the functional significance of many microtubule inner proteins remains unclear.
Haoting Wang +4 more
wiley +1 more source
Self-organization of Plk4 regulates symmetry breaking in centriole duplication
Nature Communications, 2019 During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation ...
Shohei Yamamoto, Daiju Kitagawa
doaj +1 more source