Results 111 to 120 of about 19,940 (252)

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, Volume 13, Issue 5, Page 1044-1064, July 2025.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

eLife, 2013
Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee, Nadine Muschalik, Yao Liang Wong, Christopher M Johnson, Steven Johnson, Antonina Andreeva, Karen Oegema, Susan M Lea, Jordan W Raff, Mark van Breugel   +9 more
doaj   +1 more source

Centrioles and Ciliary Structures during Male Gametogenesis in Hexapoda: Discovery of New Models

Cells, 2020
Centrioles are-widely conserved barrel-shaped organelles present in most organisms. They are indirectly involved in the organization of the cytoplasmic microtubules both in interphase and during the cell division by recruiting the molecules needed for ...
Maria Giovanna Riparbelli, Veronica Persico, Romano Dallai, Giuliano Callaini   +3 more
doaj   +1 more source

Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes [PDF]

, 2016
Centriole elimination is an essential process that occurs in female meiosis of metazoa to reset centriole number in the zygote at fertilization. How centrioles are eliminated remains poorly understood.
Albertson, Altschul, Arquint, Barakat, Brito, Burke, Carvalho-Santos, Chavali, Crowder, Delattre, Dävring, Fırat-Karalar, Firestone, Fu, Gard, Godinho, Grabherr, Grill, Gönczy, Gönczy, Hodges, Hornik, Ishikawa, Jana, Joana Borrego-Pinto, Julia König, Karreman, Kato, Kong, Kuhn, Kálmán Somogyi, Lange, Longo, Lukinavičius, Lénárt, Maderspacher, Manandhar, Matsuura, Matthia A. Karreman, Mikeladze-Dvali, Miyazaki, Mori, Mónica Bettencourt-Dias, Nakashima, Paintrand, Papadimitriou, Piel, Pierre Gönczy, Péter Lénárt, Reina, Reiter, Saiki, Sathananthan, Scheer, Schindelin, Shirato, Sluder, Sluder, Steere, Stinchcombe, Stinchcombe, Sung, Szollosi, Tamura, Terasaki, Thomas Müller-Reichert, Ucar, Uetake, von Dassow, Vorobjev, Voronina, Wang, Washitani-Nemoto, Wery, Winey, Yannick Schwab, Yi, Zhang, Zou   +78 more
core   +2 more sources

Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer [PDF]

, 2018
High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse.
Baldassarre G, Bianchet R, Cesaratto L, Coan M, Dassi E, Gardenal E, Nicoloso MS, Rampioni Vinciguerra GL, Spizzo R, Vecchione A   +9 more
core   +1 more source

The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation

Cytoskeleton, Volume 82, Issue 6, Page 360-371, June 2025.
ABSTRACT Mutations in CCDC11 (cfap53) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR) patterning of the internal organs. In Xenopus, depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, monociliated cells of the Left–Right Organizer (LRO) exhibit
Saurabh S. Kulkarni, Rachel E. Stephenson, Sarah Amalraj, Angelo Arrigo, Ewelina Betleja, James J. Moresco, John R. Yates III, Moe R. Mahjoub, Ann L. Miller, Mustafa K. Khokha   +9 more
wiley   +1 more source

The role of miR‐4284 in cancer progression and therapeutic response: Regulatory mechanisms and clinical implications

Malignancy Spectrum, Volume 2, Issue 2, Page 59-73, June 2025.
As a pivotal microRNA (miRNA), miR‐4284 exhibits noteworthy aberrant expression levels across various cancers and diseases, exerting a crucial role in modulating cancer progression and prognosis. Additionally, the article reviews the potential correlations between miR‐4284 and various contemporary treatment modalities, including but not limited to the ...
Chenhao Liang, Yaojie Feng, Yuhua Zhang, Zehua Wang, Xinming Su, Shiwei Duan   +5 more
wiley   +1 more source

The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

Molecular Cancer, 2011
Background Infection with high-risk human papillomaviruses (HPVs) such as HPV-16 is intimately associated with squamous cell carcinomas (SCCs) of the anogenital tract and a subset of oropharyngeal carcinomas.
Duensing Stefan, Treat Benjamin, Korzeniewski Nina   +2 more
doaj   +1 more source

WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity

eLife, 2020
Centrioles are characterized by a nine-fold arrangement of microtubule triplets held together by an inner protein scaffold. These structurally robust organelles experience strenuous cellular processes such as cell division or ciliary beating while ...
Emmanuelle Steib, Marine H Laporte, Davide Gambarotto, Natacha Olieric, Celine Zheng, Susanne Borgers, Vincent Olieric, Maeva Le Guennec, France Koll, Anne-Marie Tassin, Michel O Steinmetz, Paul Guichard, Virginie Hamel   +12 more
doaj   +1 more source

Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function. [PDF]

, 2016
Understanding the role of basal bodies (BBs) during development and disease has been largely overshadowed by research into the function of the cilium.
A Borovina, A Borovina, A Dauber, A Hansen, A Mahuzier, A Nasevicius, A Rodrigues-Martins, AG Kramer-Zucker, AK Maurya, BB Beck, BM McCluskey, BP Culver, C Jones, C Novorol, C Stoetzel, C Stoetzel, C Zhang, CC Leitch, CF Chakarova, CG Pearson, CJ Westlake, CJ Wilkinson, CL Kilburn, CP Toret, D Epting, DA Dehring, DF Carlson, DK Clare, DP Osborn, DY Nishimura, DY Stainier, EA Otto, ET Lim, F Zhou, FA Ran, FO Kok, G Golling, GG Slaats, H Khanna, H Zhao, IA Drummond, IJ Winfield, J Ablain, J Heasman, J Yang, JA Deane, JA Sayer, JB Li, JC Stinchcombe, JC Talbot, JD Wood, JE Lee, JS Eisen, JS Nelson, K Howe, K Joo, KD Poss, KL Pfaff, KM Nishiguchi, L He, L Ma, LC Keller, LC Keller, LE Jao, LM Baye, M Breugel van, M Dona, M Tsujikawa, ME Hodges, MH Al-Hamed, MP Dekens, N Pathak, P Haffter, P Strnad, Q Lu, R Dosch, R Simms, RD Allen, S Geimer, S Leidel, S Li, S Nair, S Roosing, SM Glasauer, SY Tay, T Avidor-Reiss, T Yabe, TJ Dam van, TJ Near, V Ravi, VM Bedell, W Driever, X Shu, Y Chen, Y Nakazawa, Y Omori, YK Durlu   +96 more
core   +1 more source