Results 101 to 110 of about 18,948 (224)

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells [PDF]

, 2014
SAS-6 proteins are thought to impart the ninefold symmetry of centrioles, but the mechanisms by which their assembly occurs within cells remain elusive. In this paper, we provide evidence that the N-terminal, coiled-coil, and C-terminal domains of HsSAS ...
Arquint, Azimzadeh, Azimzadeh, Beck, Bettencourt-Dias, Bornens, Bulseco, Carvalho-Santos, Cavalier-Smith, Chen, Chrétien, Cizmecioglu, Debora Keller, Dickson, Dippell, Dzhindzhev, Gopalakrishnan, Guichard, Guichard, Gönczy, Hatch, Haupts, Hoh, Jan Ellenberg, Kim, Kitagawa, Kleylein-Sohn, Kuriyama, Lau, Lawo, Leidel, Lettman, Lin, Lukinavičius, Maeder, Malte Wachsmuth, Marshall, Mennella, Meritxell Orpinell, Middendorp, Nakazawa, Nicolas Olivier, Nigg, Olivier, Olivier, Pierre Gönczy, Puklowski, Robert Mahen, Romain Wyss, Schmidt, Sonnen, Stevens, Strnad, Strnad, Strnad, Suliana Manley, van Breugel, Virginie Hachet, Vladar, Vulprecht, Wachsmuth   +60 more
core   +3 more sources

Centrioles in symmetric spaces [PDF]

Nagoya Mathematical Journal, 2013
AbstractWe describe all centrioles in irreducible simply connected pointed symmetric spaces of compact type in terms of the root system of the ambient space, and we study some geometric properties of centrioles.
openaire   +4 more sources

PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

eLife, 2018
Centrosome structure, function, and number are finely regulated at the cellular level to ensure normal mammalian development. Here, we characterize PPP1R35 as a novel bona fide centrosomal protein and demonstrate that it is critical for centriole ...
Andrew Michael Sydor, Etienne Coyaud, Cristina Rovelli, Estelle Laurent, Helen Liu, Brian Raught, Vito Mennella   +6 more
doaj   +1 more source

A Genetic Landscape of Euploid Miscarriages From Couples With Recurrent Pregnancy Loss Through Whole Exome Sequencing

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
Whole exome sequencing analysis on 55 couples and miscarriages from their current pregnancies reveals a significant heterogeneity and complexity in exomic variants contributing to RPL. ABSTRACT Background This study aimed to identify candidate genes for recurrent pregnancy loss (RPL).
Fanjuan Kong, Zhaochu Yin, Haiyan Zhou, Zhiyu Liu, Wanqin Xie   +4 more
wiley   +1 more source

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base [PDF]

, 2014
The transition zone (TZ) is a specialized compartment found at the base of cilia, adjacent to the centriole distal end, where axonemal microtubules (MTs) are heavily cross-linked to the surrounding membrane to form a barrier that gates the ciliary ...
Amack, Jeffrey D., Asara, John M., Goll, Mary G., Macaluso, Frank P., Perumal, Geoffrey S., Soni, Rajesh, Tay, Hwee Goon, Tsou, Meng-Fu Bryan, Wang, Won-Jing   +8 more
core   +1 more source

CENTRIOLE REPLICATION [PDF]

The Journal of Cell Biology, 1961
This paper describes the replication of centrioles during spermatogenesis in the Prosobranch snail, Viviparus malleatus Reeve. Sections for electron microscopy were cut from pieces of testis fixed in OsO4 and embedded in the polyester resin Vestopal W. Two kinds of spermatocytes are present.
openaire   +1 more source

Centriole Amplification in Zebrafish Affects Proliferation and Survival but Not Differentiation of Neural Progenitor Cells

Cell Reports, 2015
In animal cells, supernumerary centrosomes, resulting from centriole amplification, cause mitotic aberrations and have been associated with diseases, including microcephaly and cancer.
Edo Dzafic, Paulina J. Strzyz, Michaela Wilsch-Bräuninger, Caren Norden   +3 more
doaj   +1 more source

KIFC1 is Associated With Sarcomatoid Differentiation, Immune Response, and a Poor Prognosis in Clear Cell Renal Cell Carcinoma

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Introduction Centrosome clustering is a cancer‐specific adaptation that allows cells with centrosome amplification to evade mitotic catastrophe and has emerged as a potential therapeutic target. We analyzed the prognostic role of several molecules related to centrosome clustering and found that Kinesin Family Member C1 (KIFC1) was strongly ...
Yoshinori Nakano, Yohei Sekino, Go Kobayashi, Hikaru Nakahara, Shintaro Akabane, Kenshiro Takemoto, Miki Naito, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Takao Hinoi, Nobuyuki Hinata   +14 more
wiley   +1 more source

Stabilization of Cartwheel-less Centrioles for Duplication Requires CEP295-Mediated Centriole-to-Centrosome Conversion

Cell Reports, 2014
Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome.
Denisse Izquierdo, Won-Jing Wang, Kunihiro Uryu, Meng-Fu Bryan Tsou   +3 more
doaj   +1 more source

Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish [PDF]

, 2016
Photoreceptors are highly specialized sensory neurons that possess a modified primary cilium called the outer segment. Photoreceptor outer segment formation and maintenance require highly active protein transport via a process known as intraflagellar ...
Akhtar, Alfinito, Avasthi, Bachmann-Gagescu, Baker, Beech, Brockerhoff, Cao, Deacon, Eblimit, Goetz, Huang, Insinna, Insinna, Insinna, Jiang, Jimeno, Jimeno, Kodani, Krock, Lopes, Louie, Makhankov, Marszalek, Marszalek, Muresan, Muresan, Nascimento, Nonaka, Pazour, Ryan, Scholey, Shu, Stearns, Sukumaran, Traverso, Trivedi, Tsujikawa, Tuma, Westerfield, Whitehead, Wolfrum, Yamazaki, Yang, Zhao   +44 more
core   +2 more sources