Results 101 to 110 of about 13,342 (208)

Centriole Amplification in Zebrafish Affects Proliferation and Survival but Not Differentiation of Neural Progenitor Cells

Cell Reports, 2015
In animal cells, supernumerary centrosomes, resulting from centriole amplification, cause mitotic aberrations and have been associated with diseases, including microcephaly and cancer.
Edo Dzafic, Paulina J. Strzyz, Michaela Wilsch-Bräuninger, Caren Norden   +3 more
doaj   +1 more source

Atypical Centrioles During Sexual Reproduction

Frontiers in Cell and Developmental Biology, 2015
Centrioles are conserved, self-replicating, microtubule-based 9-fold symmetric subcellular organelles that are essential for proper cell division and function.
Tomer eAvidor-Reiss, Atul eKhire, Emily Lillian Fishman, Kyoung Ha Jo   +3 more
doaj   +1 more source

Production of Basal Bodies in bulk for dense multicilia formation [version 1; referees: 2 approved]

F1000Research, 2016
Centriole number is normally under tight control and is directly linked to ciliogenesis. In cells that use centrosomes as mitotic spindle poles, one pre-existing mother centriole is allowed to duplicate only one daughter centriole per cell cycle.
Xiumin Yan, Huijie Zhao, Xueliang Zhu
doaj   +1 more source

The mother centriole plays an instructive role in defining cell geometry.

PLoS Biology, 2007
Centriole positioning is a key step in establishment and propagation of cell geometry, but the mechanism of this positioning is unknown. The ability of pre-existing centrioles to induce formation of new centrioles at a defined angle relative to ...
Jessica L Feldman, Stefan Geimer, Wallace F Marshall   +2 more
doaj   +1 more source

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

eLife, 2013
Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee, Nadine Muschalik, Yao Liang Wong, Christopher M Johnson, Steven Johnson, Antonina Andreeva, Karen Oegema, Susan M Lea, Jordan W Raff, Mark van Breugel   +9 more
doaj   +1 more source

Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly

, 2010
Centrioles form the core of the centrosome in animal cells and function as basal bodies that nucleate and anchor cilia at the plasma membrane. In this paper, we report that Cep120 (Ccdc100), a protein previously shown to be involved in maintaining the ...
Moe R. Mahjoub, Tim Stearns, Zhigang Xie
core   +1 more source

Assembly and mother centriole recruitment of IFT-B subcomplexes to form IFT-B holocomplex

Cell Structure and Function
For the biogenesis and maintenance of cilia, bidirectional protein trafficking within cilia is crucial, and is conducted by intraflagellar transport (IFT) trains containing the IFT-A and IFT-B complexes that are powered by dynein-2 and kinesin-II motors.
Koshi Tasaki, Yohei Katoh, Hye-Won Shin, Kazuhisa Nakayama   +3 more
doaj   +1 more source

CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium

Cell Reports, 2018
Summary: The centrosome is the main microtubule-organizing center in animal cells and comprises a mother and daughter centriole surrounded by pericentriolar material.
Maren Mönnich, Louise Borgeskov, Loretta Breslin, Lis Jakobsen, Michaela Rogowski, Canan Doganli, Jacob M. Schrøder, Johanne B. Mogensen, Louise Blinkenkjær, Lea M. Harder, Emma Lundberg, Stefan Geimer, Søren T. Christensen, Jens S. Andersen, Lars A. Larsen, Lotte B. Pedersen   +15 more
doaj   +1 more source

The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

Molecular Cancer, 2011
Background Infection with high-risk human papillomaviruses (HPVs) such as HPV-16 is intimately associated with squamous cell carcinomas (SCCs) of the anogenital tract and a subset of oropharyngeal carcinomas.
Duensing Stefan, Treat Benjamin, Korzeniewski Nina   +2 more
doaj   +1 more source

mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins

EMBO Reports
Ependymal cells are multiciliated glial cells lining the ventricles of the mammalian brain. Their differentiation from progenitor cells involves cell enlargement and progresses through centriole amplification phases and ciliogenesis.
Alexia Bankolé, Ayush Srivastava, Asm Shihavuddin, Khaled Tighanimine, Marion Faucourt, Vonda Koka, Solene Weill, Ivan Nemazanyy, Alissa J Nelson, Matthew P Stokes, Nathalie Delgehyr, Auguste Genovesio, Alice Meunier, Stefano Fumagalli, Mario Pende, Nathalie Spassky   +15 more
doaj   +1 more source