Results 121 to 130 of about 27,287 (301)

Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

eLife, 2017
The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the ...
Kenji Sugioka, Danielle R Hamill, Joshua B Lowry, Marie E McNeely, Molly Enrick, Alyssa C Richter, Lauren E Kiebler, James R Priess, Bruce Bowerman   +8 more
doaj   +1 more source

A centriole's subdistal appendages: contributions to cell division, ciliogenesis and differentiation

Open Biology, 2020
The centrosome is a highly conserved structure composed of two centrioles surrounded by pericentriolar material. The mother, and inherently older, centriole has distal and subdistal appendages, whereas the daughter centriole is devoid of these appendage ...
Nicole A. Hall, Heidi Hehnly
semanticscholar   +1 more source

Review of expansion microscopy combined with advanced imaging modalities

Journal of Microscopy, EarlyView.
Abstract Expansion microscopy (ExM) is a powerful high‐resolution imaging technique that enhances the spatial resolution of conventional light microscopy by physically enlarging biological specimens by embedding and cross‐linking them in a swellable polymer network.
Natalie Woo, Claire M. Brown
wiley   +1 more source

Ultrastructural description and cytochemical study of the spermatozoon of Crotallus durissus (Squamata, Serpentes) [PDF]

, 2008
The present study was undertaken to elucidate some aspects about the nature of the spermatozoon ultrastructure of Crotallus durissus using cytochemical methods.
Bastos, Leonora Tavares, Báo, Sônia Nair, Cunha, Larissa Dias   +2 more
core   +1 more source

Drosophila Sas-6, Ana2 and Sas-4 self-organise into macromolecular structures that can be used to probe centriole and centrosome assembly

Journal of Cell Science, 2020
Centriole assembly requires a small number of conserved proteins. The precise pathway of centriole assembly has been difficult to study, as the lack of any one of the core assembly proteins [Plk4, Ana2 (the homologue of mammalian STIL), Sas-6, Sas-4 ...
L. Gartenmann, Catarina C Vicente, Alan Wainman, Zsofia A. Novak, Boris Sieber, Jennifer H. Richens, J. Raff   +6 more
semanticscholar   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Patterns of selection against centrosome amplification in human cell lines.

PLoS Computational Biology, 2021
The presence of extra centrioles, termed centrosome amplification, is a hallmark of cancer. The distribution of centriole numbers within a cancer cell population appears to be at an equilibrium maintained by centriole overproduction and selection ...
Marco António Dias Louro, Mónica Bettencourt-Dias, Claudia Bank   +2 more
doaj   +1 more source

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]

, 2017
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark, Brust-Mascher, Ingrid, Castro, Noemi M, Cheung, Lee, Christensen, Lana N, Huang, Bo, Jao, Li-En, Jiang, Xueer, Mahe, Karan, Ou, Tingyoung, Sepulveda, Guadalupe, Yoon, Daniel   +11 more
core   +2 more sources

The maintenance of centriole appendages and motile cilia basal body anchoring relies on TBCCD1 [PDF]

, 2023
Bruno Carmona, Carolina Camelo, Manon Mehraz, Michel Lemullois, Mariana Lince Faria, Étienne Coyaud, H. Susana Marinho, João Gonçalves, Sofia Nolasco, Francisco Pinto, Brian Raught, Anne‐Marie Tassin, France Koll, Helena Soares   +13 more
openalex   +1 more source