Results 121 to 130 of about 19,940 (252)
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, Volume 15, Issue 5, Page 856-866, May 2025.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems [PDF]
, 2011 BACKGROUND: Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin.
Daniela Pende +5 more
core +3 more sources
Cell Reports, 2014 Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome.
Denisse Izquierdo +3 more
doaj +1 more source
CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination [PDF]
, 2015 Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMCEP63 is a centrosomal protein that facilitates centriole ...
Gómez, Rocío +2 more
core +2 more sources
Centrioles go for a stroll [PDF]
Nature, 2000 In most animal cells, a pair of centrioles resides in the centrosome —an organelle that organizes the cell's microtubule system. It has long been thought that the two centrioles always remain at right angles to each other. It seems, however, that the 'daughter' centriole roams extensively throughout the cell.
openaire +2 more sources
Atypical Centrioles During Sexual Reproduction
Frontiers in Cell and Developmental Biology, 2015 Centrioles are conserved, self-replicating, microtubule-based 9-fold symmetric subcellular organelles that are essential for proper cell division and function.
Tomer eAvidor-Reiss +3 more
doaj +1 more source
Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans. [PDF]
, 2015 Oocyte meiotic spindles orient with one pole juxtaposed to the cortex to facilitate extrusion of chromosomes into polar bodies. In Caenorhabditis elegans, these acentriolar spindles initially orient parallel to the cortex and then rotate to the ...
Andaya, Armann +9 more
core +1 more source
Centriole maturation to motherhood [PDF]
Nature Reviews Molecular Cell Biology, 2015 Cep135, Ana1 (Cep295) and Asterless (Cep152) are sequentially recruited to daughter centrioles to enable their maturation into duplication-competent mother centrioles.
openaire +3 more sources
Spindle Formation in the Mouse Embryo Requires Plk4 in the Absence of Centrioles [PDF]
, 2013 During the first five rounds of cell division in the mouse embryo, spindles assemble in the absence of centrioles. Spindle formation initiates around chromosomes, but the microtubule nucleating process remains unclear.
Bury, Leah +7 more
core +1 more source
Nature CommunicationsAs daughter centrioles assemble during G2, they recruit conserved Ana3/RTTN followed by its partner Rcd4/PPP1R35. Together, this contributes to the subsequent recruitment of Ana1/CEP295, required for the centriole’s conversion to a centrosome.
Pallavi Panda +2 more
doaj +1 more source