Results 31 to 40 of about 19,940 (252)

The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis [PDF]

, 2020
The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids ...
Bucciarelli, Elisabetta, Cenci, Giovanni, Cipressa, Francesca, Di Giorgio, Maria Laura, Manzi, Diana, Morciano, Patrizia, Porrazzo, Antonella, Rong, Yikang S, Saraniero, Sara   +8 more
core   +1 more source

Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis

Cell Reports, 2016
PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole.
Minhee Kim, Brian P. O’Rourke, Rajesh Kumar Soni, Prasad V. Jallepalli, Ronald C. Hendrickson, Meng-Fu Bryan Tsou   +5 more
doaj   +1 more source

Brain microvascular endothelial cells possess a second cilium that arises from the daughter centriole

Frontiers in Molecular Biosciences, 2023
Primary cilia from the brain microvascular endothelial cells (ECs) are specialized cell-surface organelles involved in mediating sensory perception, cell signaling, and vascular stability.
Karthikeyan Thirugnanam, Ankan Gupta, Francisco Nunez, Shubhangi Prabhudesai, Amy Y. Pan, Surya M. Nauli, Ramani Ramchandran   +6 more
doaj   +1 more source

A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]

, 2017
Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla, Jao, Li-En, Wente, Susan R   +2 more
core   +1 more source

Centrioles in symmetric spaces [PDF]

Nagoya Mathematical Journal, 2013
AbstractWe describe all centrioles in irreducible simply connected pointed symmetric spaces of compact type in terms of the root system of the ambient space, and we study some geometric properties of centrioles.
openaire   +4 more sources

Stem cell decisions:A twist of fate or a niche market? [PDF]

, 2014
Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Anderson, Barker, Bellis, Bettencourt-Dias, Bowman, Brawley, Buczacki, Cabernard, Cairns, Callaini, Cao, Carmena, Castanon, Castanon, Chen, Cheng, Chrétien, Clevers, Conduit, Conti, Das, Delgehyr, Doe, Du, Durand, Falconer, Gillies, Gonzalez, Goulas, Graser, Habib, Hotz, Hsu, Inke Näthke, Ishikawa, Izumi, Izumi, Januschke, Januschke, Januschke, Jauffred, Jens Januschke, Johnston, Juanes, Kai, Knoblich, Konno, Kouzarides, Lander, Lansdorp, Lechler, Lerit, Liakopoulos, Lim, Lu, Lu, Lécuyer, Mapelli, Merdes, Moore, Morin, Morin, Morrison, Neumüller, Nigg, Nipper, Ouellet, Paridaen, Pelletier, Pereira, Piel, Postiglione, Potten, Poulson, Quyn, Razafsky, Rebollo, Rebollo, Regan, Reiter, Rocheteau, Rogers, Rusan, Sato, Segalen, Segalen, Shaw, Shitamukai, Siller, Siller, Smith, Speicher, Tajbakhsh, Takeda, Tian, Tran, Vorobjev, Wall, Wang, Wang, Wang, Werts, Williams, Wu, Yadlapalli, Yadlapalli, Yamashita, Yamashita, Yamashita, Yennek, Yoshiura, Yu, Zou   +112 more
core   +2 more sources

Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation [PDF]

Nature Communications, 2018
AbstractCentrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse
Susana Mendonça, Susana Mendonça, David Pellman, Pedro Machado, Adán Guerrero, Adán Guerrero, Marta Mesquita, Joana Paredes, Mónica Bettencourt-Dias, André Filipe Vieira, Nuno L. Barbosa-Morais, Gaëlle Marteil, Nuno Pimpão Martins, Maria E. Francia, Maria E. Francia, Katharina Santos das Dores, Bernardo P. de Almeida, Bernardo P. de Almeida, Erin M. Tranfield, Swadhin Chandra Jana, Irina S. Fonseca, Susana A. Godinho, Susana A. Godinho, Beth Villarreal   +23 more
openaire   +9 more sources

The interrelationship between APC/C and Plk1 activities in centriole disengagement

Biology Open, 2012
Summary Mother–daughter centriole disengagement, the necessary first step in centriole duplication, involves Plk1 activity in early mitosis and separase activity after APC/C activity mediates securin degradation.
Toshiyuki Hatano, Greenfield Sluder
doaj   +1 more source

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity [PDF]

, 2007
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease ...
Gruneberg, Ulrike, Kleylein-Sohn, Julia, Nigg, Erich A., Thein, Kerstin H.   +3 more
core   +3 more sources

Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy [PDF]

, 2014
Exome sequencing revealed a homozygous missense mutation (c.317C>G [p.Arg106Pro]) in POC1B, encoding POC1 centriolar protein B, in three siblings with autosomal-recessive cone dystrophy or cone-rod dystrophy and compound-heterozygous POC1B mutations (c ...
Arts, Heleen H, Coppieters, Frauke, Cremers, Frans PM, De Baere, Elfride, de Vrieze, Erik, den Hollander, Anneke I, Hetterschijt, Lisette, Hoyng, Carel B, Kremer, Hannie, Lambertus, Stanley, Lamers, Ideke JC, Letteboer, Stef JF, Peters, Theo A, POC1B Study Group, the, Roepman, Ronald, Roosing, Susanne, van den Born, L Ingeborgh, van Wijk, Erwin   +17 more
core   +6 more sources