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Uncoiling centriole duplication
Nature Cell Biology, 2004The invariant duplication of the centriole once per cell cycle is critical for cell division. SAS-5 is the most recent of three coiled-coil centriolar proteins found to be required for centriole duplication in Caenorhabditis elegans.
Bruce Nash, Bruce Bowerman
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Centriole Duplication in Lysates of Spisula solidissima Oocytes
Science, 1992A cell-free system has been developed that executes centriole duplication. Surf clam ( Spisula solidissima ) oocytes, arrested at late prophase of meiosis I, do not contain centrioles, centrosomes, or asters. Serial section high-voltage electron microscopy (HVEM) of asters and spindles isolated from potassium ...
R E, Palazzo +3 more
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Centriole duplication and orientation in mammalian cells
Medical Hypotheses, 1999The paper discusses a mechanism for semiconservative duplication of a pair of centrioles from a single parent. The mechanism accounts for the (transient or permanent) quasi-orthogonality of mammalian centrioles.
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Studying Centriole Duplication and Elongation in Human Cells
2019Centrioles assemble centrosomes and cilia/flagella, which are microtubule-based structures with key roles in cell division, polarity, motility, and signaling. Centriole biogenesis is a tightly regulated process, and deregulation of centriole numbers and structure can have dramatic consequences for cellular function and integrity.
Catarina, Peneda +2 more
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ɛ-Tubulin is required for centriole duplication and microtubule organization
Nature Cell Biology, 2002Centrosomes nucleate microtubules and serve as poles of the mitotic spindle. Centrioles are a core component of centrosomes and duplicate once per cell cycle. We previously identified epsilon-tubulin as a new member of the tubulin superfamily that localizes asymmetrically to the two centrosomes after duplication.
Paul, Chang +3 more
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Centriole Duplication and Inheritance in Drosophila melanogaster
2012Centrosomes are conserved microtubule-based organelles that are essential for animal development. In this chapter, we highlight key centrosomal proteins and describe the centrosome in the context of several developmental processes in Drosophila melanogaster.
Tomer Avidor-Reiss +3 more
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Can a reverse transcriptase be involved in centriole duplication?
Journal of Theoretical Biology, 1977Abstract Accepting tentatively that the nucleic acid thought to be present in centrioles and basal bodies is RNA rather than DNA, which had earlier been thought to be the case, it is suggested that this RNA represents the primary genome of the organelle which is replicated via a DNA intermediate with the aid of an RNA-instructed DNA polymerase ...
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Plk4 Regulates Centriole Duplication in the Embryonic Development of Zebrafish
Developmental BiologyPLK4 plays a crucial role in centriole duplication, which is essential for maintaining cellular processes such as cell division, cytoskeletal stability, and cilia formation. However, the mechanisms of PLK4 remain incompletely understood, especially in the embryonic development of vertebrate species.
Zhiyu, Mu +4 more
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Mechanism and Regulation of Centriole and Cilium Biogenesis
Annual Review of Biochemistry, 2019David K Breslow, Andrew J Holland
exaly