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Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4. [PDF]
RSC Chem BiolKovacevic A +4 more
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The DNA damage response pathway is required for multiciliated cell differentiation. [PDF]
Curr BiolJewett CE, Holland AJ, Pearson CG.
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The γ-TuRC: mastermind of multipurpose actions at the centrosome. [PDF]
Cell Mol Life SciMukhopadhyay S +3 more
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Investigating the maturation and duplication of mammalian centrioles.
, 2016 Faragher, A, Lange, B, Gull, K
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Current Opinion in Structural Biology, 2021
Centriole duplication occurs once per cell cycle. Since only a single daughter centriole is assembled adjacent to each mother centriole, symmetry around the mother centriole must be broken in the process of centriole duplication. Recent studies have established that Plk4, a master kinase for centriole duplication, can self-assemble into condensates ...
Shohei Yamamoto, Daiju Kitagawa
exaly +3 more sources
Centriole duplication occurs once per cell cycle. Since only a single daughter centriole is assembled adjacent to each mother centriole, symmetry around the mother centriole must be broken in the process of centriole duplication. Recent studies have established that Plk4, a master kinase for centriole duplication, can self-assemble into condensates ...
Shohei Yamamoto, Daiju Kitagawa
exaly +3 more sources
Centriole duplication: analogue control in a digital age [PDF]
Cell Biology International, 2010 AbstractIn preparation for mitosis, the centrosome doubles once and only once to provide the two poles of the mitotic spindle. The presence of more than two centrosomes increases the chances that mitosis will be multipolar, and chromosomes will be distributed unequally.
Greenfield Sluder, Alexey Khodjakov
exaly +4 more sources
p53 protects against genome instability following centriole duplication failure
Journal of Cell Biology, 2015 Centriole function has been difficult to study because of a lack of specific tools that allow persistent and reversible centriole depletion. Here we combined gene targeting with an auxin-inducible degradation system to achieve rapid, titratable, and ...
Yumi Uetake +2 more
exaly +3 more sources
Uncoiling centriole duplication
Nature Cell Biology, 2004The invariant duplication of the centriole once per cell cycle is critical for cell division. SAS-5 is the most recent of three coiled-coil centriolar proteins found to be required for centriole duplication in Caenorhabditis elegans.
Bruce Nash, Bruce Bowerman
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