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CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning. [PDF]
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Current Opinion in Structural Biology, 2021
Centriole duplication occurs once per cell cycle. Since only a single daughter centriole is assembled adjacent to each mother centriole, symmetry around the mother centriole must be broken in the process of centriole duplication. Recent studies have established that Plk4, a master kinase for centriole duplication, can self-assemble into condensates ...
Shohei Yamamoto, Daiju Kitagawa
exaly +3 more sources
Centriole duplication occurs once per cell cycle. Since only a single daughter centriole is assembled adjacent to each mother centriole, symmetry around the mother centriole must be broken in the process of centriole duplication. Recent studies have established that Plk4, a master kinase for centriole duplication, can self-assemble into condensates ...
Shohei Yamamoto, Daiju Kitagawa
exaly +3 more sources
Centriole duplication: analogue control in a digital age [PDF]
Cell Biology International, 2010 AbstractIn preparation for mitosis, the centrosome doubles once and only once to provide the two poles of the mitotic spindle. The presence of more than two centrosomes increases the chances that mitosis will be multipolar, and chromosomes will be distributed unequally.
Alexey Khodjakov, Greenfield Sluder
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Ab ovo or de novo? Mechanisms of centriole duplication [PDF]
Molecules and Cells, 2009 The centrosome, an organelle comprising centrioles and associated pericentriolar material, is the major microtubule organizing center in animal cells. For the cell to form a bipolar mitotic spindle and ensure proper chromosome segregation at the end of each cell cycle, it is paramount that the cell contains two and only two centrosomes.
Alexey Khodjakov, Jadranka Lončarek
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Uncoiling centriole duplication
Nature Cell Biology, 2004The invariant duplication of the centriole once per cell cycle is critical for cell division. SAS-5 is the most recent of three coiled-coil centriolar proteins found to be required for centriole duplication in Caenorhabditis elegans.
Bruce Nash, Bruce Bowerman
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p53 protects against genome instability following centriole duplication failure [PDF]
Journal of Cell Biology, 2015 Centriole function has been difficult to study because of a lack of specific tools that allow persistent and reversible centriole depletion. Here we combined gene targeting with an auxin-inducible degradation system to achieve rapid, titratable, and ...
Michael P. Snyder +2 more
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The Polo kinase Plk4 functions in centriole duplication
Nature Cell Biology, 2005The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division. By contrast, the functions of other mammalian Polo family members remain largely unknown.
Habedanck, Robert +3 more
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Studying Centriole Duplication and Elongation in Human Cells
2019Centrioles assemble centrosomes and cilia/flagella, which are microtubule-based structures with key roles in cell division, polarity, motility, and signaling. Centriole biogenesis is a tightly regulated process, and deregulation of centriole numbers and structure can have dramatic consequences for cellular function and integrity.
Catarina, Peneda +2 more
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Centriole duplication and orientation in mammalian cells
Medical Hypotheses, 1999The paper discusses a mechanism for semiconservative duplication of a pair of centrioles from a single parent. The mechanism accounts for the (transient or permanent) quasi-orthogonality of mammalian centrioles.
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