The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication. [PDF]
J Biol Chem, 2020 Badarudeen B +4 more
europepmc +1 more source
Effect of p21Waf1 and p27Kip1 on centrosome replication and proliferation of breast cancer cell
, 2010 Aberrant centrosome numbers are detected in virtually all cancers，increasing the risk for cell division errors and chromosomal instability.
Yin-Lin Ge +5 more
core
The A-C Linker controls centriole cohesion and duplication
Abstract Centrioles are evolutionarily conserved barrel-shaped organelles playing crucial roles in cell division and ciliogenesis. These functions are underpinned by specific structural sub-elements whose functions have been under investigation since many years.
Lorène Bournonville +4 more
openaire +1 more source
A theory of centriole duplication based on self-organized spatial pattern formation. [PDF]
J Cell Biol, 2019 Takao D, Yamamoto S, Kitagawa D.
europepmc +1 more source
SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL. [PDF]
J Cell Biol, 2019 Kodani A +5 more
europepmc +1 more source
c-Cbl Acts as an E3 Ligase Against DDA3 for Spindle Dynamics and Centriole Duplication during Mitosis. [PDF]
Mol Cells, 2019 Gwon D, Hong J, Jang CY.
europepmc +1 more source
Autoamplification and Competition Drive Symmetry Breaking: Initiation of Centriole Duplication by the PLK4-STIL Network. [PDF]
iScience, 2018 Leda M, Holland AJ, Goryachev AB.
europepmc +1 more source
YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect. [PDF]
Cell Death Dis, 2018 Lei Q +12 more
europepmc +1 more source
MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. [PDF]
Mol Biol Cell, 2015 Van de Mark D +3 more
europepmc +1 more source