Results 1 to 10 of about 118,231 (380)

Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations

eLife, 2020
Although originally thought to be silent chromosomal regions, centromeres are instead actively transcribed. However, the behavior and contributions of centromere-derived RNAs have remained unclear.
Leah Bury, Brittania Moodie, Jimmy Ly, Liliana S McKay, Karen HH Miga, Iain M Cheeseman   +5 more
doaj   +2 more sources

Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case report [PDF]

Journal of Medical Case Reports
Background Anti-centromere antibodies are autoantibodies that selectively bind to the centromere region of chromosomes. Studies have indicated that anti-centromere antibodies can induce microvascular alterations and tissue remodeling, ultimately leading ...
Yuya Ando, Suguru Mabuchi, Norikazu Mataki, Satoshi Nakayama, Arata Honda, Mari Kamiya, Shinsuke Yasuda, Hiroaki Takeo, Shigeaki Aono, Masayoshi Hashimoto, Kenichi Harada, Naoya Murashima   +11 more
doaj   +2 more sources

De Novo Centromere Formation and Centromeric Sequence Expansion in Wheat and its Wide Hybrids. [PDF]

PLoS Genetics, 2016
Centromeres typically contain tandem repeat sequences, but centromere function does not necessarily depend on these sequences. We identified functional centromeres with significant quantitative changes in the centromeric retrotransposons of wheat (CRW ...
Xiang Guo, Handong Su, Qinghua Shi, Shulan Fu, Jing Wang, Xiangqi Zhang, Zanmin Hu, Fangpu Han   +7 more
doaj   +2 more sources

ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis [PDF]

Genome Biology
Background Centromeres play a vital role in ensuring accurate chromosome segregation during meiosis by serving as the foundation for kinetochore assembly and microtubule attachment.
Da Yi Choi, Jiyeon Leem, Crystal Lee, Jeong Su Oh   +3 more
doaj   +2 more sources

Simulation and Quantitative Analysis of Spatial Centromere Distribution Patterns [PDF]

Cells
A prominent feature of eukaryotic chromosomes are centromeres, which are specialized regions of repetitive DNA required for faithful chromosome segregation during cell division.
Adib Keikhosravi, Krishnendu Guin, Gianluca Pegoraro, Tom Misteli   +3 more
doaj   +2 more sources

Centromere-size reduction and chromatin state dynamics following intergenomic hybridization in cotton. [PDF]

PLoS Genetics
Centromeres are pivotal for accurate chromosome segregation, yet their regulation and evolutionary dynamics remain poorly understood. Here, we investigate centromeres of the diploid species Gossypium anomalum (Ga, B-genome) that were transferred into ...
Jinlei Han, Guanjing Hu, Yan Dai, Xin Zhang, Jingjing Tian, Jialiang Zhou, Xinqi Xu, Qi Chen, Xiaobing Kou, Lei Xu, Xinyu Wu, Ziying Sun, Jiahui Geng, Lin Li, Chenyu Qiu, Teame Gereziher Mehari, Baohua Wang, Hui Zhang, Xinlian Shen, Zhenzhen Xu, Jonathan F Wendel, Kai Wang   +21 more
doaj   +2 more sources

Pan-centromere reveals widespread centromere repositioning of soybean genomes

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Centromeres are crucial for ensuring accurate chromosome segregation in eukaryotic organisms. We identified centromere satellites associated with chromosome 1 of soybean, revealing significant rearrangements and impacting the localization of
Yang Liu, Congyang Yi, Chaolan Fan, Qian Liu, Shulin Liu, Lisha Shen, Kaibiao Zhang, Yuhong Huang, Chang Liu, Yingxiang Wang, Zhixi Tian, Fang Han   +11 more
semanticscholar   +1 more source

Only the Rye Derived Part of the 1BL/1RS Hybrid Centromere Incorporates CENH3 of Wheat

Frontiers in Plant Science, 2021
The precise assembly of the kinetochore complex at the centromere is epigenetically determined by substituting histone H3 with the centromere-specific histone H3 variant CENH3 in centromeric nucleosomes.
Raheleh Karimi-Ashtiyani, Raheleh Karimi-Ashtiyani, Veit Schubert, Andreas Houben   +3 more
doaj   +1 more source

The cotton centromere contains a Ty3-gypsy-like LTR retroelement. [PDF]

PLoS ONE, 2012
The centromere is a repeat-rich structure essential for chromosome segregation; with the long-term aim of understanding centromere structure and function, we set out to identify cotton centromere sequences. To isolate centromere-associated sequences from
Song Luo, Jennifer Mach, Bradley Abramson, Rolando Ramirez, Robert Schurr, Pierluigi Barone, Gregory Copenhaver, Otto Folkerts   +7 more
doaj   +1 more source

Variation in the CENP-A sequence association landscape across diverse inbred mouse strains

Cell Reports, 2023
Summary: Centromeres are crucial for chromosome segregation, but their underlying sequences evolve rapidly, imposing strong selection for compensatory changes in centromere-associated kinetochore proteins to assure the stability of genome transmission ...
Uma P. Arora, Beth A. Sullivan, Beth L. Dumont   +2 more
doaj   +1 more source