Results 91 to 100 of about 26,352 (303)
An asymmetric centromeric nucleosome
eLife, 2018 Nucleosomes contain two copies of each core histone, held together by a naturally symmetric, homodimeric histone H3-H3 interface. This symmetry has complicated efforts to determine the regulatory potential of this architecture. Through molecular design and in vivo selection, we recently generated obligately heterodimeric H3s, providing a powerful tool ...
Yuichi Ichikawa +2 more
openaire +4 more sources
High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1
Advanced Science, EarlyView.This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng +11 more
wiley +1 more source
Centromere mechanical maturation during mammalian cell mitosis
Nature Communications, 2019 During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood.
Lauren A. Harasymiw +4 more
doaj +1 more source
Cell Reports, 2013 The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4KMT1. This recruits multiple heterochromatin proteins, including Swi6 and Chp1, to form a rigid centromere and ensure accurate chromosome ...
Pao-Chen Li +5 more
doaj +1 more source
SUMO control of centromere homeostasis
Frontiers in Cell and Developmental Biology, 2023 Centromeres are unique chromosomal loci that form the anchorage point for the mitotic spindle during mitosis and meiosis. Their position and function are specified by a unique chromatin domain featuring the histone H3 variant CENP-A.
Sebastiaan J. W. van den Berg +2 more
doaj +1 more source
Genome biology, 2004 The complete sequence of rice centromere 8 reveals a small amount of centromere-specific satellite sequence in blocks interrupted by retrotransposons and other repetitive DNA, in an arrangement that is strikingly similar in overall size and content to other centromeres of multicellular eukaryotes.
James Theuri +2 more
openaire +3 more sources
A genome-wide survey of genetic variation in gorillas using reduced representation sequencing [PDF]
, 2013 All non-human great apes are endangered in the wild, and it is therefore important to gain an understanding of their demography and genetic diversity. To date, however, genetic studies within these species have largely been confined to mitochondrial DNA and a small number of other loci.
arxiv +1 more source
Advanced Science, EarlyView.Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen +12 more
wiley +1 more source
Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome. [PDF]
PLoS Genetics, 2016 Assembly of kinetochore complexes, involving greater than one hundred proteins, is essential for chromosome segregation and genome stability. Neocentromeres, or new centromeres, occur when kinetochores assemble de novo, at DNA loci not previously ...
Laura S Burrack +12 more
doaj +1 more source
Inbreeding drives maize centromere evolution
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance The diversity of centromere-specific DNA repeats in different species (centromere paradox) and the seemingly parallel rapid evolution of the cenH3 histone protein have previously been interpreted to be related to evolutionary pressures ...
Kevin L. Schneider +3 more
semanticscholar +1 more source