Results 141 to 150 of about 51,411 (295)

Nuclear destabilisation – a possible genesis of cancer?

Biological Reviews, EarlyView.
ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal   +4 more
wiley   +1 more source

Reconstituting Drosophila Centromere Identity in Human Cells

Cell Reports, 2019
Summary: The centromere is an essential chromosomal region required for accurate chromosome segregation. Most eukaryotic centromeres are defined epigenetically by the histone H3 variant, centromere protein (CENP)-A, yet how its self-propagation is ...
Virginie Roure, Bethan Medina-Pritchard, Vasiliki Lazou, Luciano Rago, Eduard Anselm, Daniela Venegas, A. Arockia Jeyaprakash, Patrick Heun   +7 more
doaj  

Purification of a protein binding to the CDEI subregion of Saccharomyces cerevisiae centromere DNA.

, 1989
Weidong Jiang, Peter Philippsen
openalex   +1 more source

PSMD14/E2F1 Axis‐Mediated CENPF Promotes the Metastasis of Triple‐Negative Breast Cancer Through Inhibiting Ferroptosis

Cancer Science, Volume 116, Issue 8, Page 2281-2295, August 2025.
PSMD14/E2F1 axis‐mediated CENPF could promote the metastasis of BC through inhibiting arachidonic acid metabolism‐induced ferroptosis. This research might bring novel insights on discovering methods in alleviating tumor metastasis in BC. ABSTRACT The metastasis of triple‐negative breast cancer (TNBC) usually contributes to the failure of treatment ...
Meifeng Zhou, Xianglu Li, Weifeng Wang, Jianyong Wu, Jindian Tan   +4 more
wiley   +1 more source

KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death

Cancer Science, EarlyView.
Bioinformatic analysis of 42 KLHL family genes identified KLHL5 as a potential prognostic biomarker for colorectal cancer (CRC), with higher expression in the common molecular subtype (CMS) 4 CRC, which is characterized by poorer overall and recurrence‐free survival rates compared to other CMS groups. KLHL5 immunohistochemical analysis was performed on
Kyosuke Habu, Yosuke Matsuoka, Hiromi Hiyoshi, Jun Nakayama, Katsuya Watanabe, Sota Tate, Tomohisa Sakaue, Junko Murai, Konomu Uno, Hirotada Nishie, Eiji Kubota, Hiromi Kataoka, Takashi Joh, Yuji Watanabe, Taro Oshikiri, Shigeki Higashiyama   +15 more
wiley   +1 more source

Genetic Profiling Reveals the Distinctions Among MTX‐Associated DLBCL, EBV‐Positive Mucocutaneous Ulcer, and EBV + DLBCL

Cancer Science, Volume 116, Issue 8, Page 2306-2316, August 2025.
EBV‐ MTX‐DLBCL shows higher driver gene mutation rates and worse outcomes after MTX discontinuation compared to EBV+ MTX‐DLBCL. IDD‐LPDs have lower mutation rates in genes related to clonal hematopoiesis (TET2/DNMT3A) and immune evasion (CD58) compared to EBV + DLBCL. ABSTRACT The WHO recently changed the outline of immunodeficiency/dysregulation (IDD)‐
Takumi Takahashi, Keisuke Sawada, Takahisa Yamashita, Wataru Yamamoto, Yosuke Iijima, Akiko Adachi, Makoto Kashimura, Takayuki Tabayashi, Masahiro Kizaki, Takahiro Kaneko, Jun‐ichi Tamaru, Morihiro Higashi, Shuji Momose   +12 more
wiley   +1 more source

Medical genetics: advances in brief: Integration of human -satellite DNA into simian chromosomes: centromere protein binding and disruption of normal chromosome segregation [PDF]

, 1992
Nalin Thakker
openalex   +1 more source

A centromere’s obsession with transposons

Nature Plants
Transposable elements frequently invade centromeres, yet their influence on centromere function has long been enigmatic. A new study reveals that epigenetic silencing of centromeric transposable elements is essential for chromosome cohesion and proper segregation during cell division.
openaire   +4 more sources

Nucleolar Organization in Response to Transcriptional Stress

Cancer Science, EarlyView.
In this review, we provide an overview of the research field on nucleolar regulation, mainly focusing on nucleolar organization under transcriptional stress. We also highlight the importance of ribosomal DNA stability, particularly in disease prevention, including cancer.
Rikiya Imamura, Takaaki Yasuhara
wiley   +1 more source

A brief historical perspective on cell cycle control of CENP-A assembly and inheritance. [PDF]

Chromosome Res
Rowley G, Jansen LET.
europepmc   +1 more source