Results 141 to 150 of about 88,605 (330)

Innovative all‐in‐one exome sequencing strategy for diagnostic genetic testing in male infertility: Validation and 10‐month experience

open access: yesAndrology, EarlyView.
Abstract Background Current guidelines indicate that patients with extreme oligozoospermia or azoospermia should be tested for chromosomal imbalances, azoospermia factor (AZF) deletions and/or CFTR variants. For other sperm abnormalities, no genetic diagnostics are recommended.
Manon S. Oud   +12 more
wiley   +1 more source

The use of deidentified organ donor testes for research

open access: yesAndrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova   +4 more
wiley   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

PSMD14/E2F1 Axis‐Mediated CENPF Promotes the Metastasis of Triple‐Negative Breast Cancer Through Inhibiting Ferroptosis

open access: yesCancer Science, EarlyView.
PSMD14/E2F1 axis‐mediated CENPF could promote the metastasis of BC through inhibiting arachidonic acid metabolism‐induced ferroptosis. This research might bring novel insights on discovering methods in alleviating tumor metastasis in BC. ABSTRACT The metastasis of triple‐negative breast cancer (TNBC) usually contributes to the failure of treatment ...
Meifeng Zhou   +4 more
wiley   +1 more source

FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes

open access: yesCommunications Biology
Centromere pairing is crucial for synapsis in meiosis. This study delves into the Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex, specifically focusing on F-box protein 47 (FBXO47), in mouse meiosis.
Ani Ma   +4 more
doaj   +1 more source

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