Results 181 to 190 of about 59,497 (285)

Centromere 17 copy number gain reflects chromosomal instability in breast cancer [PDF]

, 2019
Kyoungyul Lee, Hyun Jeong Kim, Min Hye Jang, Sejoon Lee, Soomin Ahn, So Yeon Park   +5 more
openalex   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, Volume 158, Issue 2, Page 333-341, 15 January 2026.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

The lncRNA ELDR suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility. [PDF]

Blood Adv
Arman K, Ross J, Piskor EM, Lazzari L, Calderon V, Reulet G, Vera M, St-Hilaire E, Wurtele H, Wilhelm BT, Möröy T.   +10 more
europepmc   +1 more source

Nonhistone Scm3 and Histones CenH3-H4 Assemble the Core of Centromere-Specific Nucleosomes [PDF]

, 2007
Gaku Mizuguchi, Hua Xiao, Jan Wiśniewski, M. Mitchell Smith, Carl Wu   +4 more
openalex   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Cell line-matched reference enables high-precision functional genomics. [PDF]

Nat Commun
Corda L, Volpe E, Dallali H, Di Tommaso E, Colantoni A, Guarracino A, Chittoor SS, Capulli M, Tassone E, Giunta S.   +9 more
europepmc   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, Volume 600, Issue 1, Page 83-98, January 2026.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Rapid assembly of functional modules for generating human artificial chromosome constructs compatible with epigenetic centromere seeding. [PDF]

Chromosome Res
Birchak GJ, Gibson DG, Allu PK, Kashyap P, Glass JI, Black BE.   +5 more
europepmc   +1 more source

BRIGHT Enables High‐SNR Live‐Cell Imaging of Non‐Repetitive Sequences via Bivalent Fluorescent Nanobody‐Mediated Cascade‐Dependent Illumination

Advanced Science, Volume 13, Issue 2, 9 January 2026.
BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang   +9 more
wiley   +1 more source

Keeping centromeric identity [PDF]

Nature Reviews Molecular Cell Biology, 2012
openaire   +2 more sources