Results 11 to 20 of about 88,605 (330)
Current Biology, 2016 Centromeres, chromosomal regions that become physically linked to the spindle during cell division, ensure equal division of genetic material between daughter cells. They are ubiquitous and essential in eukaryotic life. In this primer, we ask the questions 'What defines a functional centromere?' and 'What do all centromeres have in common?' To address ...
Lisa E, Kursel, Harmit S, Malik
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Centromere Repositioning [PDF]
Genome Research, 1999 Primate pericentromeric regions recently have been shown to exhibit extraordinary evolutionary plasticity. In this paper we report an additional peculiar feature of these regions that we discovered while analyzing, by FISH, the evolutionary conservation of primate phylogenetic chromosome IX.
Montefalcone G +3 more
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A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions. [PDF]
PLoS Genetics, 2016 During meiotic prophase, telomeres cluster, forming the bouquet chromosome arrangement, and facilitate homologous chromosome pairing. In fission yeast, bouquet formation requires switching of telomere and centromere positions.
Kazuhiro Katsumata +8 more
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Holocentromeres can consist of merely a few megabase-sized satellite arrays
Nature Communications, 2023 The centromere is the chromosome region where microtubules attach during cell division. In contrast to monocentric chromosomes with one centromere, holocentric species usually distribute hundreds of centromere units along the entire chromatid.
Yi-Tzu Kuo +17 more
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The Birth of the Centromere [PDF]
Cell Cycle, 2007 The centromere is the region of the eukaryotic chromosome that determines kinetochore formation and sister chromatid cohesion. Centromeres interact with spindle microtubules to ensure chromatid segregation during mitosis and homologous chromosome segregation during meiosis I.
Esteban Montejo de Garcíni +3 more
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Dynamic epigenetic states of maize centromeres
Frontiers in Plant Science, 2015 The centromere is a specialized chromosomal region identified as the major constriction, upon which the kinetochore complex is formed, ensuring accurate chromosome orientation and segregation during cell division.
Yalin eLiu +5 more
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The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. [PDF]
, 2019 The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
A Chakraborty +57 more
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CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly [PDF]
, 2016 Human centromeres are defined by chromatin containing the histone H3 variant CENP-A assembled onto repetitive alphoid DNA sequences. By inducing rapid, complete degradation of endogenous CENP-A, we now demonstrate that once the first steps of centromere ...
Barra V. +8 more
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De Novo Centromere Formation and Centromeric Sequence Expansion in Wheat and its Wide Hybrids. [PDF]
PLoS Genetics, 2016 Centromeres typically contain tandem repeat sequences, but centromere function does not necessarily depend on these sequences. We identified functional centromeres with significant quantitative changes in the centromeric retrotransposons of wheat (CRW ...
Xiang Guo +7 more
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Recent insights into mechanisms preventing ectopic centromere formation
Open Biology, 2021 The centromere is a specialized chromosomal structure essential for chromosome segregation. Centromere dysfunction leads to chromosome segregation errors and genome instability.
Qianhua Dong +3 more
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