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The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle
Open Biology, 2020 Eukaryotic chromosome segregation relies upon specific connections from DNA to the microtubule-based spindle that forms at cell division. The chromosomal locus that directs this process is the centromere, where a structure called the kinetochore forms ...
Kathryn Kixmoeller +2 more
semanticscholar +1 more source
Chromosome Y centromere array deletion leads to impaired centromere function. [PDF]
PLoS ONE, 2014 The centromere is an essential chromosomal structure that is required for the faithful distribution of replicated chromosomes to daughter cells. Defects in the centromere can compromise the stability of chromosomes resulting in segregation errors.
Alison N Graham, Paul Kalitsis
doaj +1 more source
Super-Resolution Microscopy Reveals Diversity of Plant Centromere Architecture
International Journal of Molecular Sciences, 2020 Centromeres are essential for proper chromosome segregation to the daughter cells during mitosis and meiosis. Chromosomes of most eukaryotes studied so far have regional centromeres that form primary constrictions on metaphase chromosomes.
V. Schubert +8 more
semanticscholar +1 more source
The Birth of the Centromere [PDF]
Cell Cycle, 2007 The centromere is the region of the eukaryotic chromosome that determines kinetochore formation and sister chromatid cohesion. Centromeres interact with spindle microtubules to ensure chromatid segregation during mitosis and homologous chromosome segregation during meiosis I.
Esteban Montejo de Garcíni +3 more
openaire +2 more sources
Dynamic epigenetic states of maize centromeres
Frontiers in Plant Science, 2015 The centromere is a specialized chromosomal region identified as the major constriction, upon which the kinetochore complex is formed, ensuring accurate chromosome orientation and segregation during cell division.
Yalin eLiu +5 more
doaj +1 more source
Holocentromeres can consist of merely a few megabase-sized satellite arrays
Nature Communications, 2023 The centromere is the chromosome region where microtubules attach during cell division. In contrast to monocentric chromosomes with one centromere, holocentric species usually distribute hundreds of centromere units along the entire chromatid.
Yi-Tzu Kuo +17 more
doaj +1 more source
Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling [PDF]
, 2009 Whole mount mitotic metaphase chromosomes of different plants and animals were investigated with high resolution field emission scanning electron microscopy (FESEM) to study the ultrastructural organization of centromeres, including metacentric ...
Schroeder-Reiter, E., Wanner, Gerhard
core +1 more source
Linear assembly of a human centromere on the Y chromosome
Nature Biotechnology, 2018 The human genome reference sequence remains incomplete owing to the challenge of assembling long tracts of near-identical tandem repeats in centromeres.
Miten Jain +9 more
semanticscholar +1 more source
Centromere Repeats: Hidden Gems of the Genome
Genes, 2019 Satellite DNAs are now regarded as powerful and active contributors to genomic and chromosomal evolution. Paired with mobile transposable elements, these repetitive sequences provide a dynamic mechanism through which novel karyotypic modifications and ...
Gabrielle Hartley, R. O’Neill
semanticscholar +1 more source
Centromeric transcription maintains centromeric cohesion in human cells [PDF]
Journal of Cell Biology, 2021 Centromeric transcription has been shown to play an important role in centromere functions. However, lack of approaches to specifically manipulate centromeric transcription calls into question that the proposed functions are a direct consequence of centromeric transcription.
Yujue Chen +3 more
openaire +2 more sources