Results 31 to 40 of about 26,352 (303)
Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii.
PLoS Genetics, 2021 Deletion of native centromeres in the human fungal pathogen Cryptococcus deuterogattii leads to neocentromere formation. Native centromeres span truncated transposable elements, while neocentromeres do not and instead span actively expressed genes.
Klaas Schotanus +2 more
doaj +1 more source
Centromeric transcription maintains centromeric cohesion in human cells [PDF]
Journal of Cell Biology, 2021 Centromeric transcription has been shown to play an important role in centromere functions. However, lack of approaches to specifically manipulate centromeric transcription calls into question that the proposed functions are a direct consequence of centromeric transcription.
Yujue Chen +3 more
openaire +2 more sources
Diagnostic Cytopathology, Volume 51, Issue 1, Page 83-94, January 2023., 2023 Abstract Molecular diagnostics has expanded to become the standard of care for a variety of solid tumor types. With limited diagnostic material, it is often desirable to use cytological preparations to provide rapid and accurate molecular results. This review covers important pre‐analytic considerations and limitations, and a description of common ...
Scott A. Turner +2 more
wiley +1 more source
Transposable elements: genome innovation, chromosome diversity, and centromere conflict
Chromosome Research, 2018 Although it was nearly 70 years ago when transposable elements (TEs) were first discovered “jumping” from one genomic location to another, TEs are now recognized as contributors to genomic innovations as well as genome instability across a wide variety ...
Savannah J. Klein, R. O’Neill
semanticscholar +1 more source
Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation
Journal of Cell Biology, 2018 Centromeres are essential for chromosome segregation and are specified epigenetically by the presence of the histone H3 variant CENP-A. In flies and humans, replenishment of the centromeric mark is uncoupled from DNA replication and requires the removal ...
G. Bobkov, N. Gilbert, P. Heun
semanticscholar +1 more source
Sequence Dependence of Electronic Transport in DNA [PDF]
phys. stat. sol. (b) 243, 373-377 (2005), 2005 We study electronic transport in long DNA chains using the tight-binding approach for a ladder-like model of DNA. We find insulating behavior with localizaton lengths xi ~ 25 in units of average base-pair seperation. Furthermore, we observe small, but significant differences between lambda-DNA, centromeric DNA, promoter sequences as well as random-ATGC
arxiv +1 more source
Genes, Chromosomes and Cancer, Volume 62, Issue 2, Page 93-100, February 2023., 2023 Abstract Chromosomal instability is a common feature in malignant tumors. Previous studies have indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A, and TP53 may contribute to chromosomal aberrations in cancer by disrupting different aspects of the cell cycle and DNA damage checkpoint machinery.
Natalie Andersson +6 more
wiley +1 more source
EWSR1 maintains centromere identity
Cell Reports, 2023 Summary: The centromere is essential for ensuring high-fidelity transmission of chromosomes. CENP-A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere identity.
Risa Kitagawa +4 more
doaj
Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation. [PDF]
PLoS Genetics, 2018 Centromere is a specialized chromatin domain that plays a vital role in chromosome segregation. In most eukaryotes, centromere is surrounded by the epigenetically distinct heterochromatin domain. Heterochromatin has been shown to contribute to centromere
Jinpu Yang +7 more
doaj +1 more source
Centromere Satellite Repeats Have Undergone Rapid Changes in Polyploid Wheat Subgenomes[OPEN]
The Plant Cell, 2019 Variation in centromere satellite sequence and copy number, and structural rearrangements produce asymmetries in polyploid wheat homeologs, highlighting the role in homolog pairing during meiosis. Centromeres mediate the pairing of homologous chromosomes
H. Su +5 more
semanticscholar +1 more source