Results 41 to 50 of about 55,531 (223)

Sister centromere fusion during meiosis I depends on maintaining cohesins and destabilizing microtubule attachments.

open access: yesPLoS Genetics, 2019
Sister centromere fusion is a process unique to meiosis that promotes co-orientation of the sister kinetochores, ensuring they attach to microtubules from the same pole during metaphase I.
Lin-Ing Wang, Arunika Das, Kim S McKim
doaj   +1 more source

Structure and Stability of Telocentric Chromosomes in Wheat. [PDF]

open access: yesPLoS ONE, 2015
In most eukaryotes, centromeres assemble at a single location per chromosome. Naturally occurring telocentric chromosomes (telosomes) with a terminal centromere are rare but do exist.
Dal-Hoe Koo   +3 more
doaj   +1 more source

The Role of Human Centromeric RNA in Chromosome Stability

open access: yesFrontiers in Molecular Biosciences, 2021
Chromosome instability is a hallmark of cancer and is caused by inaccurate segregation of chromosomes. One cellular structure used to avoid this fate is the kinetochore, which binds to the centromere on the chromosome.
Simon Leclerc, Katsumi Kitagawa
doaj   +1 more source

Mepylome: A Point‐of‐Care Tumor Diagnostic Toolkit for Tumor DNA Methylation and Copy Number Analysis

open access: yesAdvanced Intelligent Systems, EarlyView.
DNA methylation and chromosomal copy number profiling have recently become essential for tumor diagnostics. The open‐source tool Mepylome enables this task in clinical routine. It combines several machine learning strategies and allows users to interactively examine respective data through an intuitive graphical interface. Running up to 65 times faster
Jon Brugger   +6 more
wiley   +1 more source

Centromere mechanical maturation during mammalian cell mitosis

open access: yesNature Communications, 2019
During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood.
Lauren A. Harasymiw   +4 more
doaj   +1 more source

Replication Fork Stability Is Essential for the Maintenance of Centromere Integrity in the Absence of Heterochromatin

open access: yesCell Reports, 2013
The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4KMT1. This recruits multiple heterochromatin proteins, including Swi6 and Chp1, to form a rigid centromere and ensure accurate chromosome ...
Pao-Chen Li   +5 more
doaj   +1 more source

Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations

open access: yeseLife, 2020
Although originally thought to be silent chromosomal regions, centromeres are instead actively transcribed. However, the behavior and contributions of centromere-derived RNAs have remained unclear.
Leah Bury   +5 more
doaj   +1 more source

Pan-centromere reveals widespread centromere repositioning of soybean genomes

open access: yesProceedings of the National Academy of Sciences, 2023
Centromere repositioning refers to a de novo centromere formation at another chromosomal position without sequence rearrangement. This phenomenon was frequently encountered in both mammalian and plant species and has been implicated in genome evolution and speciation.
Yang Liu   +11 more
openaire   +2 more sources

Phylogenetic systematics of Juncaceae

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise Juncaceae has needed taxonomic revision for some time. Specifically, the genus Juncus s.l. is known to be paraphyletic because five small southern‐hemisphere genera have been shown repeatedly to be nested within it. In 2022, a new classification was proposed, based on phylogenies built from one nuclear and three plastid regions ...
Reed J. Kenny   +2 more
wiley   +1 more source

Temporal characterization of homology-independent centromere coupling in meiotic prophase.

open access: yesPLoS ONE, 2010
BackgroundOver the past thirty years several reports of the pairing or association of non-homologous centromeres during meiotic prophase have appeared in the literature.
David Obeso, Dean S Dawson
doaj   +1 more source

Home - About - Disclaimer - Privacy