Results 41 to 50 of about 99,978 (325)

Key centromere proteins in Physcomitrella patens identified via SPIDER and IP-MS

Shenzhen Daxue xuebao. Ligong ban
Plant artificial chromosomes play a crucial role in synthetic biology, wherein key centromere proteins represent essential components in synthesizing these chromosomes. However, the identification of centromere proteins in plants remains limited.
LIU Xuedong, WONG Yuming, WANG Mingliang, MO Beixin   +3 more
doaj   +1 more source

Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase. [PDF]

PLoS Genetics, 2010
Eukaryotic centromeres are maintained at specific chromosomal sites over many generations. In the budding yeast Saccharomyces cerevisiae, centromeres are genetic elements defined by a DNA sequence that is both necessary and sufficient for function ...
Amnon Koren, Hung-Ji Tsai, Itay Tirosh, Laura S Burrack, Naama Barkai, Judith Berman   +5 more
doaj   +1 more source

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. [PDF]

, 2014
DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear.
Blaikley, EJ, Bähler, J, Deegan, RS, Hulme, L, Humphrey, TC, Hussey, S, Kasparek, TR, Marguerat, S, Nakagawa, T, Pai, CC, Sarkar, S, Tinline-Purvis, H, Walker, CA, Wee, BY   +13 more
core   +1 more source

Insights into Centromere DNA Bending Revealed by the Cryo-EM Structure of the Core Centromere Binding Factor 3 with Ndc10

Cell Reports, 2018
Summary: The centromere binding factor 3 (CBF3) complex binds the third centromere DNA element in organisms with point centromeres, such as S. cerevisiae.
Wenjuan Zhang, Natalya Lukoynova, Shomon Miah, Jonathan Lucas, Cara K. Vaughan   +4 more
doaj   +1 more source

Centromere plasmid: a new genetic tool for the study of Plasmodium falciparum. [PDF]

PLoS ONE, 2012
The introduction of transgenes into Plasmodium falciparum, a highly virulent human malaria parasite, has been conducted either by single crossover recombination or by using episomal plasmids.
Shiroh Iwanaga, Tomomi Kato, Izumi Kaneko, Masao Yuda   +3 more
doaj   +1 more source

Chromosomal diversification and karyotype evolution of diploids in the cytologically diverse genus Prospero (Hyacinthaceae) [PDF]

, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Andrew R Leitch, Eva M Temsch, Franz Speta, Hanna Weiss-Schneeweiss, Jang, Tae-Soo, John Parker, Khatere Emadzade, Tae-Soo Jang   +7 more
core   +2 more sources

Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-AHCP−3 Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes

Epigenetics & Chromatin, 2018
Background The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis.
Jing Zhu, Kevin Chi Lok Cheng, Karen Wing Yee Yuen   +2 more
doaj   +1 more source

Chromosome Segregation Is Biased by Kinetochore Size [PDF]

, 2018
Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Aguiar, P, Almeida, A C, Damas, J, Drpic, D, Khodjakov, A, Larkin, D M, Lewin, H A, Maiato, H, Renda, F   +8 more
core   +2 more sources

Structure and evolution of metapolycentromeres

Вавиловский журнал генетики и селекции
Metapolycentromeres consist of multiple sequential domains of centromeric chromatin associated with a centromere-specific variant of histone H3 (CENP-A), functioning collectively as a single centromere.
E. O. Grishko, P. M. Borodin
doaj   +1 more source

Transgenerational inheritance of centromere identity requires the CENP-A N-terminal tail in the C. elegans maternal germ line.

PLoS Biology, 2021
Centromere protein A (CENP-A) is a histone H3 variant that defines centromeric chromatin and is essential for centromere function. In most eukaryotes, CENP-A-containing chromatin is epigenetically maintained, and centromere identity is inherited from one
Reinier F Prosée, Joanna M Wenda, Isa Özdemir, Caroline Gabus, Kamila Delaney, Francoise Schwager, Monica Gotta, Florian A Steiner   +7 more
doaj   +1 more source