Results 41 to 50 of about 26,352 (303)
de novo variant calling identifies cancer mutation signatures in the 1000 Genomes Project
Human Mutation, Volume 43, Issue 12, Page 1979-1993, December 2022., 2022 Abstract Detection of de novo variants (DNVs) is critical for studies of disease‐related variation and mutation rates. To accelerate DNV calling, we developed a graphics processing units‐based workflow. We applied our workflow to whole‐genome sequencing data from three parent‐child sequenced cohorts including the Simons Simplex Collection (SSC), Simons
Jeffrey K. Ng +16 more
wiley +1 more source
Variation in the CENP-A sequence association landscape across diverse inbred mouse strains
Cell Reports, 2023 Summary: Centromeres are crucial for chromosome segregation, but their underlying sequences evolve rapidly, imposing strong selection for compensatory changes in centromere-associated kinetochore proteins to assure the stability of genome transmission ...
Uma P. Arora +2 more
doaj
Electronic transport and localization in short and long DNA [PDF]
Modern Methods for Theoretical Physical Chemistry of Biopolymers
(pp. 407-427), 2006, 2005 The question of whether DNA conducts electric charges is intriguing to physicists and biologists alike. The suggestion that electron transfer/transport in DNA might be biologically important has triggered a series of experimental and theoretical investigations.
arxiv +1 more source
, 2022 Journal of Cutaneous Immunology and Allergy, Volume 5, Issue 6, Page 227-228, December 2022.
Noritaka Oyama +3 more
wiley +1 more source
Atypical centromeres in plants – what they can tell us
Frontiers in Plant Science, 2015 The centromere, visible as the primary constriction of condensed metaphase chromosomes, is a defined chromosomal locus essential for genome stability. It mediates transient assembly of a multi-protein complex, the kinetochore, which enables interaction ...
Maria eCuacos +2 more
doaj +1 more source
RNAi is a critical determinant of centromere evolution in closely related fungi
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The “centromere paradox” refers to rapidly evolving and highly diverse centromere DNA sequences even in closely related eukaryotes. However, factors contributing to this rapid divergence are largely unknown.
V. Yadav +9 more
semanticscholar +1 more source
Sequential assembly of centromeric proteins in male mouse meiosis. [PDF]
PLoS Genetics, 2009 The assembly of the mitotic centromere has been extensively studied in recent years, revealing the sequence and regulation of protein loading to this chromosome domain. However, few studies have analyzed centromere assembly during mammalian meiosis. This
María Teresa Parra +6 more
doaj +1 more source
Point centromere activity requires an optimal level of centromeric noncoding RNA
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Budding yeast harbors a simple point centromere, which is originally believed to be sequence dependent without much epigenetic regulation and is transcription incompatible, as inserting a strong promoter upstream inactivates the centromere ...
Y. Ling, K. Yuen
semanticscholar +1 more source
Real-Time Monitoring of Fluorescence in situ Hybridization (FISH) Kinetics [PDF]
published 2018, 2018 We present a novel method for real-time monitoring and kinetic analysis of fluorescence in situ hybridization (FISH). We implement the method using a vertical microfluidic probe containing a microstructure designed for rapid switching between a probe solution and a non-fluorescent imaging buffer.
arxiv +1 more source
Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase. [PDF]
PLoS Genetics, 2010 Eukaryotic centromeres are maintained at specific chromosomal sites over many generations. In the budding yeast Saccharomyces cerevisiae, centromeres are genetic elements defined by a DNA sequence that is both necessary and sufficient for function ...
Amnon Koren +5 more
doaj +1 more source