Results 51 to 60 of about 88,605 (330)

Csi1 links centromeres to the nuclear envelope for centromere clustering [PDF]

Journal of Cell Biology, 2012
In the fission yeast Schizosaccharomyces pombe, the centromeres of each chromosome are clustered together and attached to the nuclear envelope near the site of the spindle pole body during interphase. The mechanism and functional importance of this arrangement of chromosomes are poorly understood.
Scott P. Kallgren, Songtao Jia, Tatiana Kurchuk, Yu Wang, Jiyong Wang, Zhou Zhou, Haitong Hou, Elizabeth A. Miller, Fred Chang   +8 more
openaire   +3 more sources

Structure and evolution of metapolycentromeres

Вавиловский журнал генетики и селекции
Metapolycentromeres consist of multiple sequential domains of centromeric chromatin associated with a centromere-specific variant of histone H3 (CENP-A), functioning collectively as a single centromere.
E. O. Grishko, P. M. Borodin
doaj   +1 more source

Amplification and adaptation of centromeric repeats in polyploid switchgrass species. [PDF]

, 2018
Centromeres in most higher eukaryotes are composed of long arrays of satellite repeats from a single satellite repeat family. Why centromeres are dominated by a single satellite repeat and how the satellite repeats originate and evolve are among the most
Braz, Guilherme T, Casler, Michael D, Han, Yonghua, Jiang, Jiming, Schmutz, Jeremy, Yang, Xueming, Zeng, Zixian, Zhang, Pingdong, Zhang, Tao, Zhao, Hainan, Zhu, Bo   +10 more
core   +2 more sources

Pericentromeric organization at the fusion point of mouse Robertsonian translocation chromosomes [PDF]

, 2001
In mammals, Robertsonian (Rb) translocation (the joining of two telo/acrocentric chromosomes at their centromere to form a metacentric) is the most effective process in chromosomal evolution leading to speciation; its occurrence also affects human health
Capanna, E., Garagna, S., Marziliano, N., Redi, C.A., Searle, J.B., Zuccotti, M.   +5 more
core   +3 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity

Advanced Science, EarlyView.
This study uncovers a spatiotemporal regulation of STING activity by linear ubiquitination in antiviral immunity. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the ER to the Golgi apparatus for activation.
Yong Zhang, Yesheng Fu, Lihua Qiang, Mengyuan Zhao, Zhe Lu, Zhuo Zhao, Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu, Lingqiang Zhang   +13 more
wiley   +1 more source

The Role of Human Centromeric RNA in Chromosome Stability

Frontiers in Molecular Biosciences, 2021
Chromosome instability is a hallmark of cancer and is caused by inaccurate segregation of chromosomes. One cellular structure used to avoid this fate is the kinetochore, which binds to the centromere on the chromosome.
Simon Leclerc, Katsumi Kitagawa
doaj   +1 more source

Reprogramming of human cells to pluripotency induces CENP-A chromatin depletion [PDF]

Open Biology, 2020
Pluripotent stem cells (PSCs) are central to development as they are the precursors of all cell types in the embryo. Therefore, maintaining a stable karyotype is essential, both for their physiological role as well as for their use in regenerative ...
Inês Milagre, Carolina Pereira, Raquel A. Oliveira, Lars E. T. Jansen   +3 more
doaj   +1 more source

Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex [PDF]

, 2012
Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated multi-step process.
Bancroft, James M., Cardoso, M. Cristina, Deng, Wen, Diekmann, Stephan, Döring, Volker, Emmerth, Stephan, Eskat, Anja, Hellwig, Daniela, Hofmeister, Antje, Hoischen, Christian, Leonhardt, Heinrich, McAinsh, Andrew D., Meraldi, Patrick, Rudolphi, Sven, Ulbricht, Tobias   +14 more
core   +3 more sources

A New Histone at the Centromere? [PDF]

Cell, 2012
The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino et al. reveal a new level of complexity for centromeric chromatin, by showing that the kinetochore complex CENP-T-W-S-X shares structural and functional ...
P. Todd Stukenberg, Daniel R. Foltz
openaire   +3 more sources