Results 51 to 60 of about 26,352 (303)
SEQUENCE OF CENTROMERE SEPARATION: ROLE OF CENTROMERIC HETEROCHROMATIN [PDF]
Genetics, 1982 ABSTRACT The late metaphase-early anaphase cells from various tissues of male Mus musculus, M. poschiavinus, M. spretus, M. castaneus, female and male Bos taurus (cattle) and female Myopus schisticolor (wood lemming) were analyzed for centromeres that showed separation into two daughter centromeres and those that did not show such ...
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Centromere Assembly and Propagation [PDF]
Cell, 2007 Centromere assembly provides a unique example of how elaborate protein structures can be assembled onto DNA, independent of sequence, and then stably propagated through numerous cell divisions. Here, we review the possible epigenetic strategies that organisms ranging from yeast to human use to assemble and propagate active centromeres.
Danesh Moazed, Corey A. Morris
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Epigenetics & Chromatin, 2018 Background The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis.
Jing Zhu +2 more
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Centromere plasmid: a new genetic tool for the study of Plasmodium falciparum. [PDF]
PLoS ONE, 2012 The introduction of transgenes into Plasmodium falciparum, a highly virulent human malaria parasite, has been conducted either by single crossover recombination or by using episomal plasmids.
Shiroh Iwanaga +3 more
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Centromere scission drives chromosome shuffling and reproductive isolation
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The centromere is an essential chromosomal element that enables faithful segregation of chromosomes during cell division. In many species, centromeres are enriched in transposons and repetitive elements, and centromeres have been proposed to
V. Yadav +3 more
semanticscholar +1 more source
A Positive Spin on the Centromere [PDF]
Journal of End-to-End-testing, 2009 The properties of centromeric nucleosomes have been the subject of considerable debate and controversy. Furuyama and Henikoff (2009) now provide surprising evidence that centromeric nucleosomes wrap DNA in an orientation that is opposite to that of canonical nucleosomes.
Karolin Luger +2 more
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Prenatal Diagnosis, Volume 42, Issue 13, Page 1627-1635, December 2022., 2022 Abstract Objectives The congenital diaphragmatic hernia (CDH), characterized by malformation of the diaphragm and lung hypoplasia, is a common and severe birth defect that affects around 1 in 4000 live births. However, the etiology of most cases of CDH remains unclear.
Marie Boisson +11 more
wiley +1 more source
Nature Communications, 2019 Nucleosomes containing the histone H3 variant CENP-A are the epigenetic mark of centromeres, the kinetochore assembly sites required for chromosome segregation.
D. Pan +5 more
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The CINs of the centromere [PDF]
Biochemical Society Transactions, 2013 Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss of heterochromatin.
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Csi1 links centromeres to the nuclear envelope for centromere clustering [PDF]
Journal of Cell Biology, 2012 In the fission yeast Schizosaccharomyces pombe, the centromeres of each chromosome are clustered together and attached to the nuclear envelope near the site of the spindle pole body during interphase. The mechanism and functional importance of this arrangement of chromosomes are poorly understood.
Scott P. Kallgren +8 more
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