Results 61 to 70 of about 118,231 (380)
Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase. [PDF]
PLoS Genetics, 2010 Eukaryotic centromeres are maintained at specific chromosomal sites over many generations. In the budding yeast Saccharomyces cerevisiae, centromeres are genetic elements defined by a DNA sequence that is both necessary and sufficient for function ...
Amnon Koren +5 more
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Nature Communications, 2019 Nucleosomes containing the histone H3 variant CENP-A are the epigenetic mark of centromeres, the kinetochore assembly sites required for chromosome segregation.
D. Pan +5 more
semanticscholar +1 more source
The CINs of the centromere [PDF]
Biochemical Society Transactions, 2013 Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss of heterochromatin.
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Centromere Assembly and Propagation [PDF]
Cell, 2007 Centromere assembly provides a unique example of how elaborate protein structures can be assembled onto DNA, independent of sequence, and then stably propagated through numerous cell divisions. Here, we review the possible epigenetic strategies that organisms ranging from yeast to human use to assemble and propagate active centromeres.
Danesh Moazed, Corey A. Morris
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A family case of fertile human 45,X,psu dic(15;Y) males [PDF]
, 2006 We report on a familial case including four male probands from three generations with a 45,X,psu dic(15;Y)(p11.2;q12) karyotype. 45,X is usually associated with a female phenotype and only rarely with maleness, due to translocation of small Y chromosomal
Andersson M +29 more
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Epigenetics & Chromatin, 2018 Background The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis.
Jing Zhu +2 more
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Structure and evolution of metapolycentromeres
Вавиловский журнал генетики и селекцииMetapolycentromeres consist of multiple sequential domains of centromeric chromatin associated with a centromere-specific variant of histone H3 (CENP-A), functioning collectively as a single centromere.
E. O. Grishko, P. M. Borodin
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Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae
Frontiers in Plant Science, 2021 Centromere drive model describes an evolutionary process initiated by centromeric repeats expansion, which leads to the recruitment of excess kinetochore proteins and consequent preferential segregation of an expanded centromere to the egg during female ...
Marie Krátká +4 more
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Keeping the Centromere under Control: A Promising Role for DNA Methylation
Cells, 2019 In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity.
A. Scelfo, D. Fachinetti
semanticscholar +1 more source
Csi1 links centromeres to the nuclear envelope for centromere clustering [PDF]
Journal of Cell Biology, 2012 In the fission yeast Schizosaccharomyces pombe, the centromeres of each chromosome are clustered together and attached to the nuclear envelope near the site of the spindle pole body during interphase. The mechanism and functional importance of this arrangement of chromosomes are poorly understood.
Scott P. Kallgren +8 more
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