Results 61 to 70 of about 26,352 (303)
Keeping the Centromere under Control: A Promising Role for DNA Methylation
Cells, 2019 In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity.
A. Scelfo, D. Fachinetti
semanticscholar +1 more source
PLoS Biology, 2021 Centromere protein A (CENP-A) is a histone H3 variant that defines centromeric chromatin and is essential for centromere function. In most eukaryotes, CENP-A-containing chromatin is epigenetically maintained, and centromere identity is inherited from one
Reinier F Prosée +7 more
doaj +1 more source
Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation
Journal of Cell Biology, 2019 Aurora B localizes to centromeres, but it is unclear if this influences chromosome segregation in mitosis. Liang et al. find that two phospho-histone marks separately recruit Aurora B to centromeres and act redundantly for faithful chromosome segregation.
Cai Liang +8 more
semanticscholar +1 more source
The Plant Genome, Volume 15, Issue 4, December 2022., 2022 Abstract Late blight (LB), caused by the oomycete Phytophthora infestans, is one of the most destructive diseases of the cultivated tomato (Solanum lycopersicum L.) and potato (Solanum tuberosum L.) worldwide. Genetic changes in the pathogen have resulted in the emergence of new genotypes, overcoming formerly effective fungicides or host resistance ...
Matthew T. Sullenberger +4 more
wiley +1 more source
Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae
Frontiers in Plant Science, 2021 Centromere drive model describes an evolutionary process initiated by centromeric repeats expansion, which leads to the recruitment of excess kinetochore proteins and consequent preferential segregation of an expanded centromere to the egg during female ...
Marie Krátká +4 more
doaj +1 more source
Genes, 2018 Maintenance of an intact genome is essential for cellular and organismal homeostasis. The centromere is a specialized chromosomal locus required for faithful genome inheritance at each round of cell division.
E. M. Black, Simona Giunta
semanticscholar +1 more source
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Molecular Stiffening by Macrocycle Clustering
Angewandte Chemie, EarlyView.Macrocyclic hosts can remotely rigidify part of a molecule, implying that this part need not be included inside a macrocycle to be stiffened. Here, we show that multiple binding by synthetic hosts CB[7] and CB[8] can selectively rigidify fragments of a tetratopic molecule in water causing a gradual stiffening from the periphery to the core.
Hang Yin +11 more
wiley +2 more sources
Structure and Stability of Telocentric Chromosomes in Wheat. [PDF]
PLoS ONE, 2015 In most eukaryotes, centromeres assemble at a single location per chromosome. Naturally occurring telocentric chromosomes (telosomes) with a terminal centromere are rare but do exist.
Dal-Hoe Koo +3 more
doaj +1 more source
The Role of Human Centromeric RNA in Chromosome Stability
Frontiers in Molecular Biosciences, 2021 Chromosome instability is a hallmark of cancer and is caused by inaccurate segregation of chromosomes. One cellular structure used to avoid this fate is the kinetochore, which binds to the centromere on the chromosome.
Simon Leclerc, Katsumi Kitagawa
doaj +1 more source