Results 71 to 80 of about 88,605 (330)

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

Advanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia, Fuwen Wang, Xiaoyu Luo, Shuang Li, Yang Lyu, Yining Zheng, Zhijie Ma, Kaixing Qu, Rende Song, Jianyong Liu, Jicai Zhang, Basang Wangdui, Basang Zhuzha, Suolang Quji, Li Zhao, Silang Wangmu, Ciren Luobu, Nima Cangjue, Danzeng Luosang, Suolang Sizhu, Haijian Cheng, Ruizhe Li, Zhipeng Wu, Ruihua Dang, Yongzhen Huang, Xianyong Lan, Luohao Xu, Haifei Hu, WaiYee Low, Zhuqing Zheng, Yu Wang, Yuanpeng Gao, Lu Deng, Johannes A. Lenstra, Jianlin Han, Xueyi Yang, Wenfa Lyu, Bizhi Huang, Chuzhao Lei, Ningbo Chen   +39 more
wiley   +1 more source

Replication Fork Stability Is Essential for the Maintenance of Centromere Integrity in the Absence of Heterochromatin

Cell Reports, 2013
The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4KMT1. This recruits multiple heterochromatin proteins, including Swi6 and Chp1, to form a rigid centromere and ensure accurate chromosome ...
Pao-Chen Li, Ruben C. Petreaca, Amanda Jensen, Ji-Ping Yuan, Marc D. Green, Susan L. Forsburg   +5 more
doaj   +1 more source

Defining the consequences of endogenous genetic variation within a novel family of Schizosaccharomyces pombe heterochromatin nucleating sequences

G3: Genes, Genomes, Genetics, 2021
Centromeres are essential for genetic inheritance—they prevent aneuploidy by providing a physical link between DNA and chromosome segregation machinery.
Arati Joshi, Meryl J Musicante, Bayly S Wheeler   +2 more
doaj   +1 more source

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.

, 2002
In most aerobic organisms hemoperoxidases play a major role in H(2)O(2)-detoxification, but trypanosomatids have been reported to lack this activity.
Kelly, John M, Mauricio, Isabel L, Obado, Samson O, Wilkinson, Shane R   +3 more
core   +2 more sources

Centromere DNA Dynamics: Latent Centromeres and Neocentromere Formation [PDF]

The American Journal of Human Genetics, 1997
The centromere is a vital chromosomal structure that provides all living cells with the ability to faithfully partition their genetic material during mitotic and meiotic cell divisions. It functions by holding newly replicated sister chromatids together, allowing the attachment of spindle microtubules, and orchestrating the ordered movement of ...
openaire   +3 more sources

Subgenome Dominance in Allotetraploid Actinidia valvata Regulates RNA m6A Modification for Waterlogging Tolerance

Advanced Science, EarlyView.
The waterlogging tolerance of allotetraploid Actinidia valvata is inherited from one of its diploid progenitors, which leads to subgenome expression dominance, mediated by complex mechanisms including altered chromatin accessibility and DNA methylation.
Xiaoli Hu, Changbin Xu, Xiaolan Li, Lin Li, Yu Bao, Miaofeng Gu, Xinyi Li, Liuqing Huo, Jinli Gong, Xiaolong Li, Minhui Wang, Kai Xu, Xueren Yin, Zhangjun Fei, Xuepeng Sun   +14 more
wiley   +1 more source

Centromere mechanical maturation during mammalian cell mitosis

Nature Communications, 2019
During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood.
Lauren A. Harasymiw, Damien Tank, Mark McClellan, Neha Panigrahy, Melissa K. Gardner   +4 more
doaj   +1 more source

3D Analysis of chromosome architecture: advantages and limitations with SEM [PDF]

, 2005
Three-dimensional mitotic plant chromosome architecture can be investigated with the highest resolution with scanning electron microscopy compared to other microscopic techniques at present.
Allen TD, Hainfeld JF, Harrison CJ, Inaga S, Inaga S, Martin R, Ris H, Sumner AT, Tanaka K   +8 more
core   +1 more source

Long‐Read Whole‐Genome Sequencing Uncovers a Deletion Upstream to HOXD13 Causing Synpolydactyly

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Synpolydactyly (SPD) is a heterogeneous distal‐limb malformation syndrome, characterized by webbing and duplication of adjacent digits. SPD1, the most common type, is attributed to disease‐causing variants in HOXD13, a transcription factor in the HOXD cluster that is essential for limb development. Here, we present a challenging exome‐negative
Jonathan Rips, Rivka Birnbaum, Chaim Jalas, Ayala Frumkin, Shamir Zenvirt, Julia Rachanaev, Avraham Shaag, Tamar Harel, Orly Elpeleg, Hagar Mor‐Shaked   +9 more
wiley   +1 more source

Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome. [PDF]

PLoS Genetics, 2016
Assembly of kinetochore complexes, involving greater than one hundred proteins, is essential for chromosome segregation and genome stability. Neocentromeres, or new centromeres, occur when kinetochores assemble de novo, at DNA loci not previously ...
Laura S Burrack, Hannah F Hutton, Kathleen J Matter, Shelly Applen Clancey, Ivan Liachko, Alexandra E Plemmons, Amrita Saha, Erica A Power, Breanna Turman, Mathuravani Aaditiyaa Thevandavakkam, Ferhat Ay, Maitreya J Dunham, Judith Berman   +12 more
doaj   +1 more source