Results 71 to 80 of about 26,352 (303)

Reprogramming of human cells to pluripotency induces CENP-A chromatin depletion [PDF]

Open Biology, 2020
Pluripotent stem cells (PSCs) are central to development as they are the precursors of all cell types in the embryo. Therefore, maintaining a stable karyotype is essential, both for their physiological role as well as for their use in regenerative ...
Inês Milagre, Carolina Pereira, Raquel A. Oliveira, Lars E. T. Jansen   +3 more
doaj   +1 more source

Quiescent cells actively replenish CENP-A nucleosomes to maintain centromere identity and proliferative potential

bioRxiv, 2018
Centromeres provide a robust model for epigenetic inheritance as they are specified by sequence-independent mechanisms involving the histone H3-variant CENP-A.
Zachary Swartz, Liliana S. McKay, Kuan-Chung Su, L. Bury, Abbas Padeganeh, P. Maddox, Kristin A. Knouse, I. Cheeseman   +7 more
semanticscholar   +1 more source

De novo reconstruction of satellite repeat units from sequence data [PDF]

arXiv, 2023
Satellite DNA are long tandemly repeating sequences in a genome and may be organized as high-order repeats (HORs). They are enriched in centromeres and are challenging to assemble. Existing algorithms for identifying satellite repeats either require the complete assembly of satellites or only work for simple repeat structures without HORs.
arxiv  

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

Structure and evolution of metapolycentromeres

Вавиловский журнал генетики и селекции
Metapolycentromeres consist of multiple sequential domains of centromeric chromatin associated with a centromere-specific variant of histone H3 (CENP-A), functioning collectively as a single centromere.
E. O. Grishko, P. M. Borodin
doaj   +1 more source

Centromere repositioning causes inversion of meiosis and generates a reproductive barrier

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Mutations in inner kinetochore components induce centromere repositioning without alteration in the centromeric DNA sequence, revealing a feedback mechanism underlying the high epigenetic stability of the centromere.
Min Lu, Xiangwei He
semanticscholar   +1 more source

Centromere repositioning in mammals [PDF]

Heredity, 2011
The evolutionary history of chromosomes can be tracked by the comparative hybridization of large panels of bacterial artificial chromosome clones. This approach has disclosed an unprecedented phenomenon: 'centromere repositioning', that is, the movement of the centromere along the chromosome without marker order variation.
M. Rocchi, N. Archidiacono, W. Schempp, O. Capozzi, STANYON, ROSCOE ROBERT   +4 more
openaire   +4 more sources

Immunosuppressive Drugs in Early Systemic Sclerosis and Prevention of Damage Accrual

Arthritis Care &Research, EarlyView.
Objective Organ damage in patients with systemic sclerosis (SSc) in individual organs such as the lungs may be prevented by receiving immunosuppressive drugs (ISs). A new measure of global organ damage, the Scleroderma Clinical Trials Consortium Damage Index (SCTC‐DI), has allowed us to investigate whether receiving ISs may reduce global organ damage ...
Murray Baron, Mandana Nikpour, Dylan Hansen, Susanna Proudman, Wendy Stevens, on behalf of the Australian Scleroderma Interest Group and the Canadian Scleroderma Research Group, Joanne Sahhar, Nava Ferdowsi, Kathleen Morrisroe, Laura Ross, Gene Siew Ngian, Jennifer Walker, Janet Roddy, Lauren Host, Mohammed Osman, Peter Docherty, Paul Fortin, Marvin Jacob Fritzler, Genevieve Gyger, Alena Ikic, Niall Jones, Elzbieta Kaminska, Maggie Larche, Sophie Ligier, Ada Man, Ariel Masetto, Janet Pope, David Robinson, Tatiana Sofia Rodriguez‐Reyna, Mianbo Wang   +29 more
wiley   +1 more source

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Nature Communications, 2016
Chromosomal instability (CIN) is a hallmark of cancer that contributes to tumour heterogeneity and other malignant properties. Aberrant centromere and kinetochore function causes CIN through chromosome missegregation, leading to aneuploidy ...
Weiguo Zhang, J. Mao, Wei Zhu, A. K. Jain, K. Liu, James B. Brown, G. Karpen   +6 more
semanticscholar   +1 more source

A New Histone at the Centromere? [PDF]

Cell, 2012
The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino et al. reveal a new level of complexity for centromeric chromatin, by showing that the kinetochore complex CENP-T-W-S-X shares structural and functional ...
P. Todd Stukenberg, Daniel R. Foltz
openaire   +3 more sources