Results 81 to 90 of about 26,352 (303)

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

Combined measurement of circulating tumor cell counts and serum tumor marker levels enhances the screening efficiency for malignant versus benign pulmonary nodules

Thoracic Cancer, Volume 13, Issue 23, Page 3393-3401, December 2022., 2022
We aimed to evaluate whether or not the combination measurement of circulating tumor cell counts and serum tumor marker levels can enhance the screening efficiency for malignant versus benign pulmonary nodules. The results show this combination was effective, especially for the early stages of cancer and solitary pulmonary nodules within 2 cm. Abstract
Guojun Ma, Dawei Yang, Yang Li, Meng Li, Jingtao Li, Jianhua Fu, Zhongmin Peng   +6 more
wiley   +1 more source

Defining the consequences of endogenous genetic variation within a novel family of Schizosaccharomyces pombe heterochromatin nucleating sequences

G3: Genes, Genomes, Genetics, 2021
Centromeres are essential for genetic inheritance—they prevent aneuploidy by providing a physical link between DNA and chromosome segregation machinery.
Arati Joshi, Meryl J Musicante, Bayly S Wheeler   +2 more
doaj   +1 more source

Centromere Biology: Transcription Goes on Stage

Molecular and Cellular Biology, 2018
Accurate chromosome segregation is a fundamental process in cell biology. During mitosis, chromosomes are segregated into daughter cells through interactions between centromeres and microtubules in the mitotic spindle.
C. Perea-Resa, Michael D. Blower
semanticscholar   +1 more source

Centromere DNA Dynamics: Latent Centromeres and Neocentromere Formation [PDF]

The American Journal of Human Genetics, 1997
The centromere is a vital chromosomal structure that provides all living cells with the ability to faithfully partition their genetic material during mitotic and meiotic cell divisions. It functions by holding newly replicated sister chromatids together, allowing the attachment of spindle microtubules, and orchestrating the ordered movement of ...
openaire   +3 more sources

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source

Chinese expert consensus on the diagnosis and treatment of HER2‐altered non–small cell lung cancer

Thoracic Cancer, Volume 14, Issue 1, Page 91-104, January 2023., 2023
To improve the diagnosis and treatment of HER2‐altered non‐small cell lung cancer in China, we reached consensus on detection strategy based on alteration type, sample selection, detection method, quality control, and treatment suggestion. Moreover, we systematically reviewed the clinical efficacy, resistance mechanisms, and development status of HER2‐
Shirong Zhang, Wenxian Wang, Chunwei Xu, Yongchang Zhang, Xiuyu Cai, Qian Wang, Zhengbo Song, Ziming Li, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Jingjing Liu, Anwen Liu, Wen Li, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Gen Lin, Long Huang, Jingping Yuan, Zhansheng Jiang, Xingxiang Pu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Hui Guo, Qian Chu, Rui Meng, Xuewen Liu, Jingxun Wu, Jin Zhou, Zhengfei Zhu, Weiwei Pan, Xiaowei Dong, Fei Pang, Kai Wang, Chao Yao, Guomin Lin, Site Li, Zhi Yang, Jiancheng Luo, Hongtao Jia, Xiuqing Nie, Liping Wang, Youcai Zhu, Xiao Hu, Yanru Xie, Xinqing Lin, Jing Cai, Yang Xia, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jing Kang, Jiatao Zhang, Chao Zhang, Wenbin Gao, Jianhui Huang, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Dong Wang, Zhaofeng Wang, Bing Wan, Donglai Lv, Genhua Yu, Lin Shi, Yuanli Xia, Feng Gao, Xiaochen Zhang, Tao Xu, Wei Zhou, Haixia Wang, Zhefeng Liu, Nong Yang, Lin Wu, Qiming Wang, Guansong Wang, Zhuan Hong, Jiandong Wang, Meiyu Fang, Yong Fang, Yiping Zhang, Yong Song, Shenglin Ma, Wenfeng Fang, Yuanzhi Lu   +98 more
wiley   +1 more source

Cellular and Molecular Mechanisms of Centromere Drive

Cold Spring Harbor Symposia on Quantitative Biology, 2018
The asymmetric outcome of female meiosis I, whereby an entire set of chromosomes are discarded into a polar body, presents an opportunity for selfish genetic elements to cheat the process and disproportionately segregate to the egg.
M. Lampson, B. E. Black
semanticscholar   +1 more source

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3

Advanced Science, EarlyView.
MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi, Yu Tian, Yu‐fan Wang, Yi‐ran Zhang, Ying Yin, Qing Tian, Lei Li, Bing‐xin Ma, Ximiao He, Li‐quan Zhou   +9 more
wiley   +1 more source

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The centromere is a highly specialized genomic locus playing a critical role in chromosome segregation during cell division and is made of characteristic repetitive DNA sequences.
Simona Giunta, H. Funabiki
semanticscholar   +1 more source