Results 181 to 190 of about 23,863 (196)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

From Adipose Dysfunction to Multi-Organ Steatosis: Defining the Metabolic Steatotic Axis. [PDF]

Curr Issues Mol Biol
Fajkić A, Lam YW, Jahić R, Ćavar I, Markotić A, Belančić A.   +5 more
europepmc   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

Metabolic crossroads in insulin resistance: exploring lipid dysregulation and inflammation. [PDF]

Front Immunol
Saadati S, Godini R, Reddy A, Teede H, Mousa A.   +4 more
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Individual lipid alterations at the origin of neuronal Ceramide Synthase defects. [PDF]

PLoS Genet
Ziegler AB, Wesselmann C, Beckschäfer K, Wulf AL, Dhiman N, Soba P, Thiele C, Bauer R, Tavosanis G.   +8 more
europepmc   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Deciphering the Role of Different Ceramide Synthases in the Human Cardiomyocyte Hypertrophic Response. [PDF]

Metabolites
Wiley AM, Krueger MA, Sotoodehnia N, Umans JG, Hoofnagle AN, Lemaitre RN, Totah RA, Gharib SA.   +7 more
europepmc   +1 more source

Advances in Engineered Extracellular Vesicles for the Treatment of Atherosclerosis and Atherothrombosis – Next‐Generation Cardiovascular Nanomedicine

Small Structures, Volume 7, Issue 3, March 2026.
Exosomes (small extracellular vesicles) are nanosized vesicles produced naturally by living cells. They can be engineered by various techniques to deliver biologically active molecules to injury sites in atherosclerosis and atherothrombosis. Therefore, an exosome‐based multifunctional nanomedicine for the diagnosis, monitoring, and treatment of these ...
Tuan Huu Nguyen, Nhu Thao Huynh, Be'eri Niego, Christoph E. Hagemeyer, Rong Xu   +4 more
wiley   +1 more source

Targeting ceramide metabolism to restore hypoxia-induced apoptosis in p53-deficient colon cancer cells. [PDF]

PLoS One
Mechleb K, Hourani N, Fakhry M, Alyamani OA, Hage-Sleiman R, Younes H, Fayad AA, Soudani N, Sakr A, Darwiche N, Nemer G, Saab R, Mrad M, Dbaibo G.   +13 more
europepmc   +1 more source