Results 201 to 210 of about 33,232 (287)

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Deciphering the Role of Different Ceramide Synthases in the Human Cardiomyocyte Hypertrophic Response. [PDF]

Metabolites
Wiley AM, Krueger MA, Sotoodehnia N, Umans JG, Hoofnagle AN, Lemaitre RN, Totah RA, Gharib SA.   +7 more
europepmc   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Rare skin disease helps uncover mechanisms of acyl ceramide biosynthesis. [PDF]

J Lipid Res
Tollinger S, Ortner D, Trafoier T, Moosbrugger-Martinz V, Gruber R, Schmuth M.   +5 more
europepmc   +1 more source

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite

Traffic, Volume 27, Issue 1, March 2026.
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao, Amuza Byaruhanga Lucky, Gang Ning, Xian Xia, Xiaoying Liang, Faiza Siddiqui, Hui Min, Chengqi Wang, Xiaolian Li, Z. Hong Zhou, Liwang Cui   +10 more
wiley   +1 more source

Increased plasma ceramide levels are associated with arterial stiffness and vascular ageing: a cross-sectional study. [PDF]

Lipids Health Dis
Ren J, Wang G, Wang Y, Li L, Sun J, Liu S, Wu X, Zhang C, Ruan L.   +8 more
europepmc   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Orm2 promotes nitrogen-induced sphingolipid production and endocytosis via Orm1 phosphorylation. [PDF]

J Lipid Res
Ren J, Hannun YA.
europepmc   +1 more source

Fenofibrate decreases plasma ceramide in type 2 diabetes patients: A novel marker of CVD?

, 2017
Mikaël Croyal, Zied Kaabia, Luis León, Stéphane Ramin‐Mangata, T. Baty, F. Fall, Stéphanie Billon‐Crossouard, Audrey Aguesse, Tim Hollstein, David Sullivan, Estelle Nobécourt, Gilles Lambert, Michel Krempf   +12 more
openalex   +2 more sources