Results 61 to 70 of about 648,897 (295)

Anesthetic Strategies in Cerebral Edema: Navigating Neurological Challenges Amid Trauma, Tumors and Therapeutic Advances

Journal of Education, Health and Sport
Cerebral edema, characterized by abnormal fluid accumulation in brain tissue leading to increased intracranial pressure, poses significant challenges for anesthesiologists. This review delves into the pathophysiology, clinical manifestations, diagnostic
Maciej Świercz, Szymon Markowiak, Marta Wardęszkiewicz, Wiktoria Jabłońska, Amelia Kasprzak, Monika Truchta, Aleksandra Mańkowska, Agata Kolano, Anna Pejas   +8 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Brain CT Scan Diagnostic and Prognostic Value in Patients With Acute Liver Failure and Cerebral Edema: A Multicenter Cohort Study

Critical Care Explorations
OBJECTIVE:. Patients with acute liver failure (ALF) may develop cerebral edema. We aimed to study the CT scan diagnostic and prognostic value among patients with ALF and cerebral edema. DESIGN:. International multicenter retrospective cohort. SETTING:. U.
Filipe S. Cardoso, MD, MSc, William M. Lee, MD, Constantine J. Karvellas, MD, MSc, U.S. Acute Liver Failure Study Group, W.M. Lee, MD, Anne M. Larson, MD, Iris Liou, MD, Oren Fix, MD, Michael Schilsky, MD, Timothy McCashland, MD, J. Eileen Hay, MBBS, Natalie Murray, MD, A. Obaid S. Shaikh, MD, Andres Blei, MD, Daniel Ganger, MD, Atif Zaman, MD, Steven H.B. Han, MD, Robert Fontana, MD, Brendan McGuire, MD, Raymond T. Chung, MD, Alastair Smith, MB, ChB, Robert Brown, MD, Jeffrey Crippin, MD, Adrian Reuben, MBBS, Santiago Munoz, MD, Rajender Reddy, MD, R. Todd Stravitz, MD, Lorenzo Rossaro, MD, Raj Satyanarayana, MD, Tarek Hassanein, MD, Constantine J. Karvellas, MD, Jodi Olson, MD, Ram Subramanian, MD, James Hanje, MD, Bilal Hameed, MD, Grace Samuel, Ezmina Lalani, Carla Pezzia, Corron Sanders, PhD, Nahid Attar, Linda S. Hynan, PhD, Valerie Durkalski, PhD, Wenle Zhao, PhD, Jaime Speiser, Catherine Dillon, Holly Battenhouse, Michelle Gottfried   +46 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Blood Flow and Continuous EEG Changes during Symptomatic Plateau Waves

Brain Sciences, 2018
Benign meningiomas uncommonly lead to significant cerebral edema, with only a few cases previously reported in the medical literature. The present study describes the case of a 49-year-old female who had a meningioma resection. She subsequently developed
Natalie Kreitzer, Maggie Huynh, Brandon Foreman   +2 more
doaj   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Aquaporin-4 gene silencing protects injured neurons after early cerebral infarction

Neural Regeneration Research, 2015
Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebral infarction.
Zhan-ping He, Hong Lu
doaj   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Therapeutic implications of melatonin in cerebral edema [PDF]

, 2014
Cerebral edema/brain edema refers to the accumulation of fluid in the brain and is one of the fatal conditions that requires immediate medical attention.
Ling, Eng-Ang, Kaur, Charanjit, Rathnasamy, Gurugirijha   +2 more
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