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Metabolome Changes in Cerebral Ischemia [PDF]
Cells, 2020 Cerebral ischemia is caused by perturbations in blood flow to the brain that trigger sequential and complex metabolic and cellular pathologies. This leads to brain tissue damage, including neuronal cell death and cerebral infarction, manifesting ...
T. Shin +8 more
semanticscholar +5 more sources
Cerebral ischemia and neuroregeneration
Neural Regeneration Research, 2018 Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke ...
R. H. Lee +7 more
semanticscholar +4 more sources
Sirt1 in cerebral ischemia [PDF]
Brain Circulation, 2015 Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments.
K. Koronowski, M. Perez-Pinzon
semanticscholar +5 more sources
Toll-like receptors in cerebral ischemic inflammatory injury [PDF]
Journal of Neuroinflammation, 2011 Cerebral ischemia triggers acute inflammation, which has been associated with an increase in brain damage. The mechanisms that regulate the inflammatory response after cerebral ischemia are multifaceted.
Yang Qing-Wu, Lin Sen, Wang Yan-Chun
doaj +5 more sources
Inhibition of the cGAS–STING pathway: contributing to the treatment of cerebral ischemia-reperfusion injury [PDF]
Neural Regeneration ResearchThe cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart, liver, brain, and kidney, but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically reviewed.
Hang Yang +6 more
doaj +2 more sources
Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis [PDF]
Brazilian Journal of Medical and Biological Research, 2021 It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies.
Junna He +6 more
doaj +1 more source
Pathophysiology of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: A Review
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2021 Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many years of investigation and clinical trials.
W. Dodd +9 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Its increasing incidence has led stroke to be the second leading cause of death worldwide. Despite significant advances in recanalization strategies, patients are still at risk for ischemia/reperfusion injuries in this pathophysiology, in which ...
Anamaria Jurcău, A. Simion
semanticscholar +1 more source
Optimal Cerebral Perfusion Pressure During Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage [PDF]
, 2022 OBJECTIVES: The recommendation of induced hypertension for delayed cerebral ischemia treatment after aneurysmal subarachnoid hemorrhage has been challenged recently and ideal pressure targets are missing.
Albanna, W. +14 more
core +1 more source
Journal of Neuroinflammation, 2021 Background It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson’s disease (PD).
Neus Rabaneda-Lombarte +5 more
doaj +1 more source