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Mitophagy in Cerebral Ischemia and Ischemia/Reperfusion Injury [PDF]
Frontiers in Aging Neuroscience, 2021 Ischemic stroke is a severe cerebrovascular disease with high mortality and morbidity. In recent years, reperfusion treatments based on thrombolytic and thrombectomy are major managements for ischemic stroke patients, and the recanalization time window ...
Luoan Shen +7 more
semanticscholar +5 more sources
Metabolome Changes in Cerebral Ischemia [PDF]
Cells, 2020 Cerebral ischemia is caused by perturbations in blood flow to the brain that trigger sequential and complex metabolic and cellular pathologies. This leads to brain tissue damage, including neuronal cell death and cerebral infarction, manifesting ...
T. Shin +8 more
semanticscholar +5 more sources
Cerebral ischemia and neuroregeneration
Neural Regeneration Research, 2018 Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke ...
R. H. Lee +7 more
semanticscholar +4 more sources
Sirt1 in cerebral ischemia [PDF]
Brain Circulation, 2015 Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment of cerebral ischemia, mostly stroke and cardiac arrest, is limited and new neuroprotective therapies are
K. Koronowski, M. Perez-Pinzon
semanticscholar +5 more sources
Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia [PDF]
European Journal of Medical ResearchWith high disability and mortality rate as well as highly complex pathogenesis, cerebral ischemia is highly morbid, prone to recurrence. To comprehensively understand the pathophysiological process of cerebral ischemia and to find new therapeutic ...
Jiaming Liu +11 more
doaj +2 more sources
Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis [PDF]
Brazilian Journal of Medical and Biological Research, 2021 It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies.
Junna He +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 Its increasing incidence has led stroke to be the second leading cause of death worldwide. Despite significant advances in recanalization strategies, patients are still at risk for ischemia/reperfusion injuries in this pathophysiology, in which ...
Anamaria Jurcău, A. Simion
semanticscholar +1 more source
Pathophysiology of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: A Review
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2021 Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many years of investigation and clinical trials.
W. Dodd +9 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2021 Background It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson’s disease (PD).
Neus Rabaneda-Lombarte +5 more
doaj +1 more source
Thrombolysis for Cerebral Ischemia [PDF]
Frontiers in Neurology, 2010 The care for patients with acute ischemic stroke has been revolutionized by the clinical application of fibrinolysis. Intravenous recombinant tissue plasminogen activator (rt-PA) has been proven to improve functional outcomes following acute ischemic stroke and can be administered to a select group of patients up to 4.5 h after symptom onset. Time from
Elias A. Giraldo +2 more
openaire +4 more sources