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Metabolome Changes in Cerebral Ischemia [PDF]
Cells, 2020 Cerebral ischemia is caused by perturbations in blood flow to the brain that trigger sequential and complex metabolic and cellular pathologies. This leads to brain tissue damage, including neuronal cell death and cerebral infarction, manifesting clinically as ischemic stroke, which is the cause of considerable morbidity and mortality worldwide.
Tae Hwan Shin +8 more
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Cerebral ischemia and neuroregeneration
Neural Regeneration Research, 2018 Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited.
Tsung Han Hsieh +7 more
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Sirt1 in cerebral ischemia [PDF]
Brain Circulation, 2015 Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment of cerebral ischemia, mostly stroke and cardiac arrest, is limited and new neuroprotective therapies are
Miguel A. Perez-Pinzon +1 more
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Toll-like receptors in cerebral ischemic inflammatory injury [PDF]
Journal of Neuroinflammation, 2011 Cerebral ischemia triggers acute inflammation, which has been associated with an increase in brain damage. The mechanisms that regulate the inflammatory response after cerebral ischemia are multifaceted.
Yang Qing-Wu, Lin Sen, Wang Yan-Chun
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Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis [PDF]
Brazilian Journal of Medical and Biological Research, 2021 It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies.
Junna He +6 more
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International Journal of Molecular Sciences, 2021 Its increasing incidence has led stroke to be the second leading cause of death worldwide. Despite significant advances in recanalization strategies, patients are still at risk for ischemia/reperfusion injuries in this pathophysiology, in which ...
Anamaria Jurcău, A. Simion
semanticscholar +1 more source
Optimal Cerebral Perfusion Pressure During Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage [PDF]
, 2022 OBJECTIVES: The recommendation of induced hypertension for delayed cerebral ischemia treatment after aneurysmal subarachnoid hemorrhage has been challenged recently and ideal pressure targets are missing.
Albanna, W. +14 more
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Pathophysiology of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage: A Review
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2021 Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many years of investigation and clinical trials.
W. Dodd +9 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2021 Background It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson’s disease (PD).
Neus Rabaneda-Lombarte +5 more
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Thrombolysis for Cerebral Ischemia [PDF]
Frontiers in Neurology, 2010 The care for patients with acute ischemic stroke has been revolutionized by the clinical application of fibrinolysis. Intravenous recombinant tissue plasminogen activator (rt-PA) has been proven to improve functional outcomes following acute ischemic stroke and can be administered to a select group of patients up to 4.5 h after symptom onset. Time from
Elias A. Giraldo +2 more
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