Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages
Frontiers in Cellular Neuroscience, 2017 In the brain of patients with multiple sclerosis, activated microglia/macrophages appear in active lesions and in normal appearing white matter. However, whether they play a beneficial or a detrimental role in the development of the pathology remains a ...
Tony Valente +4 more
doaj +1 more source
PLoS ONE, 2021 Cerebral ischemia causes tissue death owing to occlusion of the cerebral blood vessels, and cerebral ischemia activates mitogen-activated protein kinase (MAPK) and induces secretion of pro-inflammatory cytokines.
Il-Gyu Ko +7 more
doaj +1 more source
Function of BID - a molecule of the bcl-2 family - in ischemic cell death in the brain [PDF]
, 2002 Mitochondrial mechanisms, particularly the release of cytochrome c, play a role in the death of nerve and glial cells in cerebral ischemia. We have currently investigated whether BID, a proapoptotic molecule of the bcl-2 family and promoter of the ...
Amin-Hanjani, Sepideh +5 more
core +1 more source
Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia
Journal of Diabetes Research, 2020 Ischemic postconditioning (PC) is proved to efficiently protect diabetic patients with acute myocardial infarction from ischemia-reperfusion injury.
Ling Zhao +5 more
doaj +1 more source
Early MEK1/2 inhibition after global cerebral ischemia in rats reduces brain damage and improves outcome by preventing delayed vasoconstrictor receptor upregulation. [PDF]
PLoS ONE, 2014 BACKGROUND: Global cerebral ischemia following cardiac arrest is associated with increased cerebral vasoconstriction and decreased cerebral blood flow, contributing to delayed neuronal cell death and neurological detriments in affected patients.
Sara Ellinor Johansson +3 more
doaj +1 more source
Barrier mechanisms in neonatal stroke. [PDF]
, 2014 Clinical data continue to reveal that the incidence of perinatal stroke is high, similar to that in the elderly. Perinatal stroke leads to significant morbidity and severe long-term neurological and cognitive deficits, including cerebral palsy ...
Chip, Sophorn +2 more
core +2 more sources
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]
, 2004 Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo +4 more
core +1 more source
Neural Regeneration Research, 2015 Recent evidence has suggested the neuroprotective effects of physical exercise on cerebral ischemic injury. However, the role of physical exercise in cerebral ischemia-induced hippocampal damage remains controversial.
Nabi Shamsaei +4 more
doaj +1 more source
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia [PDF]
, 2002 Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage.
Alvarez, Dalia +7 more
core +1 more source
Neuroprotective effect of baicalin on focal cerebral ischemia in rats
Neural Regeneration Research, 2018 Baicalin, a flavonoid compound from the root of the herb Scutellaria baicalensis Georgi, has been widely used to treat patients with inflammatory disease.
Jiong Dai +8 more
doaj +1 more source