Results 41 to 50 of about 1,149,621 (388)
Cellular Physiology and Biochemistry, 2018 Background/Aims: Emerging evidence suggests that autophagy plays important roles in the pathophysiological processes of cerebral ischemia and reperfusion injury.
Yong Wang +4 more
semanticscholar +1 more source
CaMKII in cerebral ischemia [PDF]
Acta Pharmacologica Sinica, 2011 Ischemic insults on neurons trigger excessive, pathological glutamate release that causes Ca²⁺ overload resulting in neuronal cell death (excitotoxicity). The Ca²⁺/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a major mediator of physiological excitatory glutamate signals underlying neuronal plasticity and learning. Glutamate stimuli trigger
Andy Hudmon +4 more
openaire +3 more sources
Neural Regeneration Research, 2017 Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult.
In Hye Kim +12 more
doaj +1 more source
Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice
Journal of Neural Transplantation and Plasticity, 2018 Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes.
Pu Hong +9 more
semanticscholar +1 more source
Management of delayed cerebral ischemia after subarachnoid hemorrhage
Critical Care, 2016 For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed cerebral ischemia (DCI) is one of the most important causes of mortality and poor neurological outcome.
Charles L. Francoeur, S. Mayer
semanticscholar +1 more source
Cell Death and Disease, 2017 The reticulon family has been found to induce apoptosis, inhibit axon regeneration and regulate protein trafficking. However, little is known about the mechanisms of how reticulon proteins are involved in neuronal death-promoting processes during ...
Lingli Gong +5 more
semanticscholar +1 more source
Unsupervised Non Linear Dimensionality Reduction Machine Learning methods applied to Multiparametric MRI in cerebral ischemia: Preliminary Results [PDF]
Proceedings of the SPIE, Volume 9034, id. 90342O 9 pp. (2014), 2016 The evaluation and treatment of acute cerebral ischemia requires a technique that can determine the total area of tissue at risk for infarction using diagnostic magnetic resonance imaging (MRI) sequences. Typical MRI data sets consist of T1- and T2-weighted imaging (T1WI, T2WI) along with advanced MRI parameters of diffusion-weighted imaging (DWI) and ...
arxiv +1 more source
Proteostasis During Cerebral Ischemia [PDF]
Frontiers in Neuroscience, 2019 Cerebral ischemic is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation.
Audrey M. Thiebaut +6 more
openaire +3 more sources
TREM2 protects against cerebral ischemia/reperfusion injury
Molecular Brain, 2017 Although post-ischemic inflammation induced by the innate immune response is considered an essential step in the progression of cerebral ischemia injury, the role of triggering receptor expressed on myeloid cells 2 (TREM2) in the pathogenesis of ischemic
Rong Wu +8 more
semanticscholar +1 more source
Epigenetic Mechanisms in Cerebral Ischemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2013 Treatment efficacy for ischemic stroke represents a major challenge. Despite fundamental advances in the understanding of stroke etiology, therapeutic options to improve functional recovery remain limited. However, growing knowledge in the field of epigenetics has dramatically changed our understanding of gene regulation in the last few decades ...
Andreas Meisel +2 more
openaire +3 more sources