Results 41 to 50 of about 1,282,970 (403)
Autophagy, 2018 Mounting attention has been focused on defects in macroautophagy/autophagy and the autophagy-lysosomal pathway (ALP) in cerebral ischemia. TFEB (transcription factor EB)-mediated induction of ALP has been recently considered as the common mechanism in ...
Yueyang Liu +15 more
semanticscholar +1 more source
Cells, 2018 Cerebral ischemia-reperfusion is a complicated pathological process. The injury and cascade reactions caused by cerebral ischemia and reperfusion are characterized by high mortality, high recurrence, and high disability. However, only a limited number of
Weijie Xie +6 more
semanticscholar +1 more source
Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats [PDF]
, 2010 Background Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From
Guo, Jianyou +5 more
core +4 more sources
Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review
Neural Regeneration Research, 2019 To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and considering the inclusion and exclusion criteria of the study. Studies were included
Y. Naderi +3 more
semanticscholar +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Emerging evidence suggests that autophagy plays important roles in the pathophysiological processes of cerebral ischemia and reperfusion injury.
Yong Wang +4 more
semanticscholar +1 more source
The role of SUMOylation in cerebral hypoxia and ischemia [PDF]
, 2017 The process of protein modification by adding or detaching small ubiquitin-like modifiers (SUMO) proteins, called SUMOylation, contributes to the regulation of numerous processes in eukaryotic cells.
Boltze, Johannes +2 more
core +1 more source
Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice
Journal of Neural Transplantation and Plasticity, 2018 Sustained activation of NLRP3 inflammasome is closely related to diabetes and stroke. However, it is unknown whether NLRP3 inflammasome plays an essential role in stroke in diabetes.
Pu Hong +9 more
semanticscholar +1 more source
CaMKII in cerebral ischemia [PDF]
Acta Pharmacologica Sinica, 2011 Ischemic insults on neurons trigger excessive, pathological glutamate release that causes Ca²⁺ overload resulting in neuronal cell death (excitotoxicity). The Ca²⁺/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a major mediator of physiological excitatory glutamate signals underlying neuronal plasticity and learning. Glutamate stimuli trigger
Andy Hudmon +4 more
openaire +3 more sources
Neural Regeneration Research, 2017 Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult.
In Hye Kim +12 more
doaj +1 more source
Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
Frontiers in Pharmacology, 2022 Traditional Chinese medicine (TCM) has attracted a great deal of attention in the treatment of cerebral ischemia is credited with the remarkable neuroprotective effects.
Fengyan Zhao +15 more
doaj +1 more source