Results 51 to 60 of about 1,282,970 (403)
Cell Death and Disease, 2017 The reticulon family has been found to induce apoptosis, inhibit axon regeneration and regulate protein trafficking. However, little is known about the mechanisms of how reticulon proteins are involved in neuronal death-promoting processes during ...
Lingli Gong +5 more
semanticscholar +1 more source
Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]
, 2013 Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Arai, Ken +13 more
core +7 more sources
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats [PDF]
, 2007 Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition ...
Candelario-Jalil, Eduardo +4 more
core +2 more sources
Management of delayed cerebral ischemia after subarachnoid hemorrhage
Critical Care, 2016 For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed cerebral ischemia (DCI) is one of the most important causes of mortality and poor neurological outcome.
Charles L. Francoeur, S. Mayer
semanticscholar +1 more source
TREM2 protects against cerebral ischemia/reperfusion injury
Molecular Brain, 2017 Although post-ischemic inflammation induced by the innate immune response is considered an essential step in the progression of cerebral ischemia injury, the role of triggering receptor expressed on myeloid cells 2 (TREM2) in the pathogenesis of ischemic
Rong Wu +8 more
semanticscholar +1 more source
Epigenetic Mechanisms in Cerebral Ischemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2013 Treatment efficacy for ischemic stroke represents a major challenge. Despite fundamental advances in the understanding of stroke etiology, therapeutic options to improve functional recovery remain limited. However, growing knowledge in the field of epigenetics has dramatically changed our understanding of gene regulation in the last few decades ...
Andreas Meisel +2 more
openaire +3 more sources
The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review
Aging and Disease, 2017 Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important.
Wei Liang, Xiaobo Huang, Wen-qiang Chen
semanticscholar +1 more source
Pathophysiology of Cerebral Ischemia
Neurologia medico-chirurgica, 1998 The purpose of this manuscript is to briefly review the pathophysiology of cerebral ischemia. Ischemic thresholds are well-defined in lower animals. The concept of the ischemic penumbra may include regions of brain around deeper regions of ischemia but has also been defined in terms of brain salvageable by reperfusion or by pharmacological therapies ...
R. Loch Macdonald, Marcus A. Stoodley
openaire +3 more sources
Cav3.2 channel regulates cerebral ischemia/reperfusion injury: a promising target for intervention
Neural Regeneration ResearchCalcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury. Various calcium channels are involved in cerebral ischemia/reperfusion injury. Cav3.2 channel is a main subtype of T-type calcium channels.
Feibiao Dai +9 more
doaj +1 more source
The spectrum of Ischemia-induced white matter injury varies with age [PDF]
, 2013 Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Muscat, Richard +2 more
core +1 more source