Cav3.2 channel regulates cerebral ischemia/reperfusion injury: a promising target for intervention
Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury. Various calcium channels are involved in cerebral ischemia/reperfusion injury. Cav3.2 channel is a main subtype of T-type calcium channels.
Feibiao Dai+9 more
doaj +1 more source
Relationship between Hypotension and Cerebral Ischemia during Hemodialysis.
The relationship between BP and downstream ischemia during hemodialysis has not been characterized. We studied the dynamic relationship between BP, real-time symptoms, and cerebral oxygenation during hemodialysis, using continuous BP and cerebral ...
C. MacEwen+4 more
semanticscholar +1 more source
Pathophysiology of Cerebral Ischemia
The purpose of this manuscript is to briefly review the pathophysiology of cerebral ischemia. Ischemic thresholds are well-defined in lower animals. The concept of the ischemic penumbra may include regions of brain around deeper regions of ischemia but has also been defined in terms of brain salvageable by reperfusion or by pharmacological therapies ...
R. Loch Macdonald, Marcus A. Stoodley
openaire +3 more sources
Oligodendrogenesis after cerebral ischemia [PDF]
Neural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes.
Ruilan Zhang+3 more
openaire +4 more sources
Trusting Machine Learning Results from Medical Procedures in the Operating Room [PDF]
Machine learning can be used to analyse physiological data for several purposes. Detection of cerebral ischemia is an achievement that would have high impact on patient care. We attempted to study if collection of continous physiological data from non-invasive monitors, and analysis with machine learning could detect cerebral ischemia in tho different ...
arxiv
Tonic activation of extrasynaptic NMDA receptors decreases intrinsic excitability and promotes bistability in a model of neuronal activity [PDF]
NMDA receptors (NMDA-R) typically contribute to excitatory synaptic transmission in the central nervous system. While calcium influx through NMDA-R plays a critical role in synaptic plasticity, experimental evidence indicates that NMDAR-mediated calcium influx also modifies neuronal excitability through the activation of calcium-activated potassium ...
arxiv +1 more source
Anticoagulation in cerebral ischemia. [PDF]
Anticoagulation clearly benefits patients at risk of stroke from cerebral embolism. Conversely, patients with completed ischemic stroke are not benefited, and may show a higher mortality and morbidity because of hemorrhagic complications. Technical advances in the early, accurate diagnosis of cerebral hemorrhage, the constant infusion of heparin, and ...
Babette B. Weksler, Margaret Lewin
openaire +3 more sources
RatLesNetv2: A Fully Convolutional Network for Rodent Brain Lesion Segmentation [PDF]
We present a fully convolutional neural network (ConvNet), named RatLesNetv2, for segmenting lesions in rodent magnetic resonance (MR) brain images. RatLesNetv2 architecture resembles an autoencoder and it incorporates residual blocks that facilitate its optimization.
arxiv +1 more source
Hemodilution for cerebral ischemia. [PDF]
Evaluation du role de l'hemodilution hypervolemique ou normovolemique dans le traitement de l'accident ...
Roberto C. Heros, Kazuyoshi Korosue
openaire +3 more sources
Cerebral Amyloid Angiopathy Is Associated With Higher R2 Relaxation Rate: An MRI and Pathology Study
ABSTRACT Objective Cerebral amyloid angiopathy (CAA) involves β‐amyloid deposition in the walls of cortical and leptomeningeal small vessels. Transverse relaxation rate (R2) is a major source of contrast in MRI. This study tested the hypothesis that CAA is associated with R2, extracted the spatial pattern of CAA‐related R2 abnormalities, and evaluated ...
Md Tahmid Yasar+6 more
wiley +1 more source