Journal of neurology, neurosurgery, and psychiatry, 2000 Cerebral malaria may be the most common non-traumatic encephalopathy in the world. The pathogenesis is heterogeneous and the neurological complications are often part of a multisystem dysfunction. The clinical presentation and pathophysiology differs between adults and children.
Newton, CRJC, Hien, TT, White, N
openaire +2 more sources
Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia [PDF]
, 2017 Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
Hodges, James S. +8 more
core +2 more sources
Immune Modulation by Plasmodium yoelii: Insights From Lethal and Non‐Lethal Strains
Parasite Immunology, Volume 48, Issue 1, January 2026.ABSTRACT Malaria pathogenesis is driven by intricate host–parasite interactions that determine immune balance and clinical outcome. The Plasmodium yoelii model, particularly its lethal (17XL) and non‐lethal (17XNL) strains, provides a robust framework to investigate these dynamics.
Sharoen Yu Ming Lim
wiley +1 more source
Endothelial transcriptomic analysis identifies biomarkers of severe and cerebral malaria
JCI Insight, 2023 Malaria can quickly progress from an uncomplicated infection into a life-threatening severe disease. However, the unspecificity of early symptoms often makes it difficult to identify patients at high risk of developing severe disease.
Cláudia Gomes +8 more
doaj +1 more source
Fatal Cerebral Malaria in a Returning Traveler: Challenges in Recognition, Treatment, and Resource Accessibility in the United States [PDF]
J Brown Hosp MedSamuel W. Perry +4 more
europepmc +3 more sources
Cannabis‐Derived Compounds Against Plasmodium sp.: A Systematic Review of Preclinical Studies
Tropical Medicine &International Health, Volume 31, Issue 1, Page 1-9, January 2026.ABSTRACT Objective This study aims to evaluate preclinical studies on the effects and toxicity of cannabis‐derived compounds against Plasmodium sp. Methods A literature search was conducted in Web of Science, PubMed, Scopus and LILACS databases until December 2024. Studies that assessed the activity or toxicity of cannabis against Plasmodium sp.
Tácio de Mendonça Lima +5 more
wiley +1 more source
Age as a Risk Factor for Severe Manifestations and Fatal Outcome of Falciparum Malaria in European Patients: Observations from TropNetEurop and SIMPID Surveillance Data [PDF]
, 2017 Previous studies have indicated that age is a risk factor for severe falciparum malaria in nonimmune patients. The objectives of this study were to reevaluate previous findings with a larger sample and to find out how strongly clinical outcomes for ...
Behrens, R. H. +34 more
core
Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity [PDF]
, 2015 Eukaryotic high-mobility-group-box (HMGB) proteins are nuclear factors involved in chromatin remodeling and transcription regulation. When released into the extracellular milieu, HMGB1 acts as a proinflammatory cytokine that plays a central role in the ...
Abdullah S +11 more
core +1 more source
Anemia, Volume 2026, Issue 1, 2026.Background Malaria remains a major global health burden, with red blood cell (RBC) polymorphisms conferring partial protection. However, the epistatic interactions among co‐inherited RBC polymorphisms are poorly understood. We aimed to characterise how epistatic interactions among malaria‐protective RBC polymorphisms modify risk across the infection‐to‐
George Paasi +11 more
wiley +1 more source
Modulation of cerebral malaria by curcumin as an adjunctive therapy
Brazilian Journal of Infectious Diseases, 2013 Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually.
Kunal Jain +2 more
doaj +1 more source