Results 11 to 20 of about 58,585 (250)

Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets [PDF]

, 2018
Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or “lacunae”, in immunity to these Plasmodium falciparum antigens in children with severe malaria would improve our understanding of vulnerability to ...
A Bengtsson, A Claessens, A Djimde, A Salanti, A Salanti, BP Goncalves, C Lessa-Aquino, CI Newbold, CJ Treutiger, CW Wang, D Coulibaly, DH Davies, DI Baruch, F Lennartz, GI Bertin, GK Cham, GM Warimwe, HM Kyriacou, JA Chan, JA Chan, JD Smith, JT Griffin, K Marsh, KE Lyke, KE Lyke, L Turner, M Avril, M Fried, MA Travassos, MA Travassos, MJ Gardner, PD Crompton, RW Snow, S Gupta, SC Murphy, Severe falciparum malaria, SJ Rogerson, SS Oh, T Lavstsen, TE Taylor, TW Mwangi, XZ Su, Y Zhang   +42 more
core   +4 more sources

Delayed gastric emptying time in adult cerebral falciparum malaria [PDF]

Journal of Vector Borne Diseases, 2012
Objective: We hypothesize that upper gastrointestinal symptoms in cerebral malaria are due to gastric motordysfunction. But gastric motility studies in cerebral malaria are scarce.Methods: We determined gastric emptying half-time (GET½) of liquid meals ...
M.K. Mohapatra , P.C. Dash , S.C. Mohapatro & R.N. Mishra
doaj   +1 more source

CXCL10^high Microglia in Cerebral Malaria: Toward Translational Validation. [PDF]

CNS Neurosci Ther
ABSTRACT Wang et al. identify CXCL10high TNFαhigh Ki67+ microglia as drivers of CD8+ T cell recruitment during experimental cerebral malaria (ECM). We propose a conservative reframing: rather than asserting a fully validated new taxonomy, CXCL10high microglia should be considered a candidate “neuroimmune endotype” whose translational relevance requires
Rattanapitoon NK, Gordon CN, Charoenphon N, Rattanapitoon SK.   +3 more
europepmc   +2 more sources

Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria. [PDF]

PLoS Pathog
Andrew AK, Bracken TC, Nazario-Maldonado N, Russ BN, Gonzalvo KT, Brainard BM, Mackman N, Moore JM.   +7 more
europepmc   +2 more sources

Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria

Frontiers in Cellular and Infection Microbiology, 2021
Malaria is a major international public health problem that affects millions of patients worldwide especially in sub-Saharan Africa. Although many tests have been developed to diagnose malaria infections, we still lack reliable diagnostic biomarkers for ...
Mohamed Omar, Luigi Marchionni, Georg Häcker, Georg Häcker, Mohamed Tarek Badr, Mohamed Tarek Badr   +5 more
doaj   +1 more source

Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions--a prospective multicenter cohort study. [PDF]

, 2015
BACKGROUND: Severe malaria may influence inner ear function, although this possibility has not been examined prospectively. In a retrospective analysis, hearing impairment was found in 9 of 23 patients with cerebral malaria.
A Freeland, A Sowunmi, Allan Otieno, Ayola A. Adegnika, B Engdahl, Benjamin Mordmüller, Bernards Ogutu, CR Newton, D Tucci, Daniel Ansong, DH Lee, DK Mukherjee, Erich Schmutzhard, FA Claessen, Fabian Cedric Aregger, GO Adjei, Helene Verena Hurth, J Schmutzhard, J Schmutzhard, J Schmutzhard, J Schmutzhard, J Vekemans, JA Carter, Joachim Schmutzhard, Josua Kegele, L Yin, Leyla Pinggera, Lukas Oberhammer, M Wise, MJ Manary, MJ Potchen, Natalie Fischer, Patrick Zorowka, Peter Kremsner, Peter Lackner, Q Gopen, R Helbok, R Hutagalung, R Idro, Raimund Helbok, S Toovey, Saadou Issifou, Sanjeev Krishna, Sebastian Bunk, SZ Zhao, T Janssen, T Rolling, T Taylor, TG Brewer, Tsiri Agbenyega, U Proschel, V Ramos-Martin, Veronika Muigg, WE Brownell   +53 more
core   +1 more source

Association of ADAMTS13 polymorphism with cerebral malaria

Malaria Journal, 2011
Background Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of ...
Kraisin Sirima, Naka Izumi, Patarapotikul Jintana, Nantakomol Duangdao, Nuchnoi Pornlada, Hananantachai Hathairad, Tsuchiya Naoyuki, Ohashi Jun   +7 more
doaj   +1 more source

IFNGR1 polymorphisms in Thai malaria patients [PDF]

, 2009
Interferon-γ (IFN-γ) has been suggested to play an important role in the pathogenesis of malaria. To examine possible association of the IFN-γ receptor 1 (IFNGR1) polymorphisms with cerebral malaria, 312 adult patients with Plasmodium falciparum malaria (
Hananantachai Hathairad, Naka Izumi, Ohashi Jun, Patarapotikul Jintana, Tokunaga Katsushi, Tsuchiya Naoyuki, 土屋 尚之, 大橋 順   +7 more
core   +1 more source

Cytokines and Chemokines in Cerebral Malaria Pathogenesis

Frontiers in Cellular and Infection Microbiology, 2017
Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of
Josefine Dunst, Josefine Dunst, Josefine Dunst, Faustin Kamena, Faustin Kamena, Faustin Kamena, Kai Matuschewski, Kai Matuschewski   +7 more
doaj   +1 more source

Cerebral Malaria in a Patient with Recent Travel to the Congo Presenting with Delirium: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Introduction: Cerebral malaria, a syndrome of altered consciousness, is a rare and severe neurologic complication resulting from Plasmodium falciparum. 1 Historically, cerebral malaria has been seen more frequently in children rather than adults.
Megan T. Roberson, Austin T. Smith
doaj   +1 more source