Results 21 to 30 of about 23,120 (223)
CXCL10highTNFαhighKi67+ Microglia Recruit and Activate CD8+ T Cells in the Brainstem During Experimental Cerebral Malaria [PDF]
CNS Neurosci TherMicroglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Wang Y +13 more
europepmc +2 more sources
BMC Research Notes, 2009 Background Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine implicated in the pathogenesis of a number of human diseases including inflammatory neurological diseases.
Udhayakumar Venkatachalam +7 more
doaj +1 more source
Clinical Practice and Cases in Emergency Medicine, 2020 Introduction: Cerebral malaria, a syndrome of altered consciousness, is a rare and severe neurologic complication resulting from Plasmodium falciparum. 1 Historically, cerebral malaria has been seen more frequently in children rather than adults.
Megan T. Roberson, Austin T. Smith
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria.
Michael Oluwatoyin Daniyan +2 more
doaj +1 more source
Acta Neurológica Colombiana, 2021 La malaria sigue siendo un problema de salud pública que afecta especialmente a las regiones tropicales y los países en vía de desarrollo, y Latinoamérica es una región endémica para la enfermedad. A pesar de que se ha demostrado una disminución de los casos de malaria en general, los casos de malaria complicada se mantienen estables.
Yuliet Cartagena +2 more
openaire +2 more sources
Surviving cerebral malaria [PDF]
Neurology, 2018 A 48-year-old man from Minnesota declined malaria prophylaxis before hunting in South Africa. Ten days after his return, he developed body aches, confusion progressing to flaccid unresponsiveness, acute liver and renal failure, shock, and thrombocytopenia. On blood smear, Plasmodium falciparum burden was 24% and fell rapidly after aggressive management.
Eelco F. M. Wijdicks, John G. Park
openaire +3 more sources
Mediterranean Journal of Hematology and Infectious Diseases, 2017 Background & Objectives: Classically associated with Plasmodium falciparum, neurological complications in severe malaria is associated with increased morbidity and mortality.
Sohaib Ahmad +7 more
doaj +1 more source
Brain Research Bulletin, 2019 Malaria remains of significant public health concern under the tropics, causing millions of deaths annually. The disease is caused by protozoans of the Plasmodium genus, of which harbors several distinct species. Human infection occurs during the blood meal of an infected female mosquito belonging to the Anopheles genus.
Ange Landela Luzolo +1 more
openaire +2 more sources
Biology Open, 2020 Cerebral malaria caused by Plasmodium falciparum is the severest form of the disease resulting in the morbidity of a huge number of people worldwide. Development of effective curatives is essential in order to overcome the fatality of cerebral malaria ...
Malabika Chakrabarti +5 more
doaj +1 more source