Results 41 to 50 of about 58,585 (250)

A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand

Malaria Journal, 2005
Background IL-1β and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C>T ...
Tangpukdee Noppadon, Hananantachai Hathairad, Patarapotikul Jintana, Doi Akihiro, Naka Izumi, Ohashi Jun, Looareesuwan Sornchai, Tokunaga Katsushi   +7 more
doaj   +1 more source

Critical roles of endogenous glucocorticoids for disease tolerance in malaria

, 2019
During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked.
De Bosscher, Karolien, Opdenakker, Ghislain, Van den Steen, Philippe E., Vandermosten, Leen, Vanhorebeek, Ilse   +4 more
core   +1 more source

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency [PDF]

, 2005
Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily affects how the immune system manages malaria.
Allen, Judith E, Graham, Andrea L, Lamb, Tracey J, Read, Andrew F   +3 more
core   +3 more sources

Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study [PDF]

, 2012
Background In malaria endemic areas, host genetics influence whether a Plasmodium falciparum-infected child develops uncomplicated or severe malaria. TLR2 has been identified as a receptor for P. falciparum-derived glycosylphosphatidylinositol (GPI), and
BT Grimberg, CC John, CC Khor, Chandy C John, CM Johnson, CR Newton, D Kwiatkowski, E Noguchi, FP Mockenhaupt, G Krishnegowda, GE Grau, GE Grau, JA Greene, James W Kazura, Jennifer A Greene, JH Curfs, JJ Yim, JJ Yim, JM Bland, JT DaRe, K Haldar, KJ Livak, LN Henning, NA Sam-Agudu, Nadia Sam-Agudu, Peter A Zimmerman, PY Bochud, Robert O Opoka, S de Kossodo, T Boraska Jelavic, TD Schmittgen, V Amani, V Haehnel   +32 more
core   +1 more source

Gene expression profiling in blood from cerebral malaria patients and mild malaria patients living in Senegal

BMC Medical Genomics, 2019
Background Plasmodium falciparum malaria remains a major health problem in Africa. The mechanisms of pathogenesis are not fully understood. Transcriptomic studies may provide new insights into molecular pathways involved in the severe form of the disease.
Alassane Thiam, Michel Sanka, Rokhaya Ndiaye Diallo, Magali Torres, Babacar Mbengue, Nicolas Fernandez Nunez, Fatou Thiam, Gora Diop, Geneviève Victorero, Catherine Nguyen, Alioune Dieye, Pascal Rihet   +11 more
doaj   +1 more source

Cerebral malaria

Biomedicine & Pharmacotherapy, 1989
Cerebral malaria is the most important manifestation of severe Plasmodium falciparum infection. The clinical picture in South East Asian adults differs from that in African children. The children are more likely to have abnormal brain stem reflexes, signs suggestive of cerebral herniation, and raised CSF opening pressure, and to suffer persistent ...
openaire   +4 more sources

Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria

Memorias do Instituto Oswaldo Cruz, 1992
Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans.
Masamichi Aikawa, Arthur E. Brown, C. Dahlem Smith, Tatsuya Tegoshi, Russell J. Howard, Thomas H. Hasler, Yoshihiro Ito, William E. Colins, H. Kyle Webster   +8 more
doaj   +1 more source

Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria. [PDF]

PLoS ONE, 2011
In spite of the significant mortality associated with Plasmodium falciparum infection, the mechanisms underlying severe disease remain poorly understood.
Happy T Phiri, Daniel J Bridges, Simon J Glover, Jan A van Mourik, Bas de Laat, Bridon M'baya, Terrie E Taylor, Karl B Seydel, Malcolm E Molyneux, E Brian Faragher, Alister G Craig, James E G Bunn   +11 more
doaj   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Long-term effect of uncomplicated Plasmodium berghei ANKA malaria on memory and anxiety-like behaviour in C57BL/6 mice

Parasites & Vectors, 2018
Background Cerebral malaria, the main complication of Plasmodium falciparum infection in humans, is associated with persistent neurocognitive sequels both in human disease and the murine experimental model.
Luciana Pereira de Sousa, Roberto Farina de Almeida, Flávia Lima Ribeiro-Gomes, Leonardo José de Moura Carvalho, Tadeu Mello e Souza, Diogo Onofre Gomes de Souza, Cláudio Tadeu Daniel-Ribeiro   +6 more
doaj   +1 more source