Results 41 to 50 of about 2,161 (179)

Correlation between metabolomic profile constituents and feline pancreatic lipase immunoreactivity

Journal of Veterinary Internal Medicine, 2022
Background Feline pancreatic lipase immunoreactivity (fPLI) is commonly used to diagnose pancreatitis in cats (FP). Untargeted metabolomics has been extensively applied in human and veterinary medicine, but no metabolomic studies regarding FP have been ...
Magdalena Maria Krasztel, Michał Czopowicz, Olga Szaluś‐Jordanow, Agata Moroz, Marcin Mickiewicz, Jarosław Kaba   +5 more
doaj   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Decoding the Sphingolipid Landscape of Clear Cell Renal Cell Carcinoma: A Single‐Cell‐Guided Prognostic Model Built With 101 Machine Learning

Human Mutation, Volume 2026, Issue 1, 2026.
Background Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of kidney cancer and shows marked heterogeneity in progression, metastasis, and therapeutic response. Sphingolipid metabolism has emerged as an important regulator of tumor progression and the tumor microenvironment, but its cell‐state‐specific role in ccRCC ...
Jinbang Huang, Shunsheng Wang, Yaojun Zhou, Hui Zhang, Yanyuan Zhang, Shi Huang, Haiwei Su, Hongling Zhu, Yuhan Lin, Gang Deng, Shaoqiu Chen   +10 more
wiley   +1 more source

Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects

Journal of Lipid Research
The sphingolipidome contains thousands of structurally distinct sphingolipid (SL) species. This enormous diversity is generated by the combination of different long-chain bases (LCBs), N-acyl chains and head groups.
Jeongah Oh, Sneha Muralidharan, Qing Zhao, Johannes Scholz, Iris D. Zelnik, Shani Blumenreich, Tammar Joseph, Tamir Dingjan, Pradeep Narayanaswamy, Hyungwon Choi, Heiko Hayen, Federico Torta, Anthony H. Futerman   +12 more
doaj   +1 more source

Modulation of phospholipase A2 by electrostatic fields and dipole potential of glycosphingolipids in monolayers

Journal of Lipid Research, 1999
Phospholipase A2 activity against mixed monolayers of dilauroylphosphatidic acid or dilauroylphosphatidylcholine with glycosphingolipids can be reversibly modulated by external constant electrostatic fields.
Bruno Maggio
doaj   +1 more source

Characterization and Mechanism Prediction of Active Components in Fuganlin Oral Liquid for Respiratory Tract Infections Using UPLC–Q‐TOF–MS and Network Pharmacology

Journal of Analytical Methods in Chemistry, Volume 2026, Issue 1, 2026.
Fuganlin oral liquid (FOL) has been clinically employed for the treatment of pediatric qi deficiency colds, manifesting symptoms such as fever, cough, asthma, and sore throat. However, the chemical composition and bioactive components of FOL have not been clearly elucidated.
Mengyue Zhang, Feng Han, Mingxuan Yang, Zhishan Ye, Ying Cui, Yuefei Wang, Jing Yang, Xin Chai, Rongda Xu   +8 more
wiley   +1 more source

DMS as an orthogonal separation to LC/ESI/MS/MS for quantifying isomeric cerebrosides in plasma and cerebrospinal fluid[S]

Journal of Lipid Research, 2019
Cerebrosides, including glucosylceramides (GlcCers) and galactosylceramides (GalCers), are important membrane components of animal cells with deficiencies resulting in devastating lysosomal storage disorders. Their quantification is essential for disease
Hongbin Xu, Frederic R. Boucher, Thao T. Nguyen, Graeme P. Taylor, Julianna J. Tomlinson, Roberto A. Ortega, Brigitte Simons, Michael G. Schlossmacher, Rachel Saunders-Pullman, Walt Shaw, Steffany A.L. Bennett   +10 more
doaj   +1 more source

Preoperative Cer(d18:1/24:0) Shows Promise as a Candidate Predictor of Plasma Lipid Phenotypes Following Roux‐en‐Y Gastric Bypass in Women: An Exploratory Analysis of the SURMetaGIT Study

Journal of Obesity, Volume 2026, Issue 1, 2026.
Roux‐en‐Y gastric bypass (RYGB) surgery is known to improve lipid profiles in individuals with obesity, but the degree of improvement varies. Emerging evidence suggests a role for sphingolipids in modulating cholesterol metabolism. This study investigated the relationship between plasma sphingolipid changes and cholesterol improvements in women with ...
Gabriela de O. Lemos, Raquel S. M. Torrinhas, Jéssica M. Volejnik Pino, Philip C. Calder, Steven B. Heymsfield, Natasha M. Machado, Dan L. Waitzberg, Xuemei Lian   +7 more
wiley   +1 more source

Lipid class analysis of the central nervous system of myelin-deficient Wistar rats.

Journal of Lipid Research, 1982
Brains and spinal cords of myelin-deficient (md) and littermate control rats were analyzed serially for myelin lipids during the period from 13 to 32 days of age. The glycolipids of md rat brains were severely reduced and remained so during the period of
C K Csiza
doaj   +1 more source

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Ceramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Kaviya Chinnappa, Fiona Ballorin, Fiona Francis   +2 more
wiley   +1 more source