Results 21 to 30 of about 2,161 (179)

Biosynthesis of the cerebroside odd-numbered fatty acids*

Journal of Lipid Research, 1962
Rats were injected with radioactive acetate or propionate and, after four days, the saturated fatty acids were isolated from the brains and the brain cerebrosides.
Amiya K. Hajra, Norman S. Radin
doaj   +1 more source

Structural Analysis of Oxidized Cerebrosides from the Extract of Deep-Sea Sponge Aulosaccus sp.: Occurrence of Amide-Linked Allylically Oxygenated Fatty Acids

Molecules, 2020
The structural elucidation of primary and secondary peroxidation products, formed from complex lipids, is a challenge in lipid analysis. In the present study, rare minor oxidized cerebrosides, isolated from the extract of a far eastern deep-sea glass ...
Elena A. Santalova, Vladimir A. Denisenko, Pavel S. Dmitrenok   +2 more
doaj   +1 more source

Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice

Journal of Lipid Research, 2005
II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid β-galactosidase (β-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous ...
J.L. Kasperzyk, A. d'Azzo, F.M. Platt, J. Alroy, T.N. Seyfried   +4 more
doaj   +1 more source

Developing rat brain: changes in cholesterol, galactolipids, and the individual fatty acids of gangliosides and glycerophosphatides

Journal of Lipid Research, 1965
Groups of brains from rats of various ages–7 to 275 days–were analyzed for their contents of galactolipids (cerebroside + cerebroside sulfate), cholesterol, and the individual fatty acids of the gangliosides and glycerophosphatides.
Yasuo Kishimoto, W. Ewart Davies, Norman S. Radin   +2 more
doaj   +1 more source

Cerebroside galactosidase of brain

Journal of Lipid Research, 1966
The galactoside bond in cerebroside was found to be cleaved by an enzyme in rat and pig brain. Emulsified stearoyl-(14)C psychosine was used as the substrate and the extent of cleavage was studied by isolating and counting the stearoyl sphingosine (ceramide) formed.
Amiya K. Hajra, David M. Bowen, Yasuo Kishimoto, Norman S. Radin   +3 more
openaire   +3 more sources

Lipid composition of subcellular particles of human blood platelets

Journal of Lipid Research, 1969
Human platelets can be fractionated into three main subcellular components: granules, membranes, and a soluble fraction. In this study we determined the phospholipid and neutral lipid content of the granules and membranes.
Aaron J. Marcus, Harris L. Ullman, Lenore B. Safier   +2 more
doaj   +1 more source

Specific tritium labeling of cerebrosides at the 3-positions of erythro-sphingosine and threo-sphingosine

Journal of Lipid Research, 1975
Cerebrosides containing either threo- or erythro-[3-3-H]sphingosine were synthesized by a new procedure. Glucopyranosyl or galactopyranosyl ceramides were converted to their 3-keto derivatives with 2,3-dichloro-5,6-dicyanobenzoquinone and reduced with 3 ...
M. Iwamori, H.W. Moser, Y. Kishimoto
doaj   +1 more source

Changes in the fatty acid composition of cerebrosides and sulfatides of human nervous tissue with age

Journal of Lipid Research, 1968
Sphingogalactolipids (galactocerebrosides and sulfatides) have been isolated in almost quantitative yields from normal human nervous tissue (mostly brain) at different ages and their fatty acid compositions have been determined by gas-liquid ...
Lars Svennerholm, Stina Ställberg-Stenhagen   +1 more
doaj   +1 more source

New Cytotoxic Cerebrosides from the Red Sea Cucumber Holothuria spinifera Supported by In-Silico Studies

Marine Drugs, 2020
Bioactivity-guided fractionation of a methanolic extract of the Red Sea cucumber Holothuria spinifera and LC-HRESIMS-assisted dereplication resulted in the isolation of four compounds, three new cerebrosides, spiniferosides A (1), B (2), and C (3), and ...
Reda F. A. Abdelhameed, Enas E. Eltamany, Dina M. Hal, Amany K. Ibrahim, Asmaa M. AboulMagd, Tarfah Al-Warhi, Khayrya A. Youssif, Adel M. Abd El-kader, Hashim A. Hassanean, Shaimaa Fayez, Gerhard Bringmann, Safwat A. Ahmed, Usama Ramadan Abdelmohsen   +12 more
doaj   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source