Results 11 to 20 of about 28,293 (248)

miRTissue ce: extending miRTissue web service with the analysis of ceRNA-ceRNA interactions [PDF]

BMC Bioinformatics, 2020
Abstract Background Non-coding RNAs include different classes of molecules with regulatory functions. The most studied are microRNAs (miRNAs) that act directly inhibiting mRNA expression or protein translation through the interaction with a miRNAs-response element. Other RNA molecules participate in the complex network of gene regulation.
Antonino Fiannaca, Laura La Paglia, Massimo La Rosa, Riccardo Rizzo, Alfonso Urso   +4 more
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ceRNAs: miRNA Target Mimic Mimics [PDF]

Cell, 2011
In a recent issue of Cell, four papers described regulatory interactions among messenger RNAs (mRNAs) that share target sequences for the same microRNAs (miRNAs) (Cesana et al., 2011; Karreth et al., 2011; Sumazin et al., 2011; Tay et al., 2011). The authors state that these mRNAs, dubbed “competing endogenous RNAs (ceRNAs),” define a new layer of ...
Rubio-Somoza, I., Weigel, D., Franco-Zorilla, J., García, J., Paz-Ares, J.   +4 more
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Translating ceRNA susceptibilities into correlation functions [PDF]

Biophysical Journal, 2017
Competition to bind microRNAs induces an effective positive crosstalk between their targets, therefore known as ‘competing endogenous RNAs’ or ceRNAs. While such an effect is known to play a significant role in specific situations, estimating its strength from data and, experimentally, in physiological conditions appears to be far from simple.
Martirosyan, A., Marsili, M., De Martino, A.   +2 more
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Deciphering the rules of ceRNA networks [PDF]

Proceedings of the National Academy of Sciences, 2013
Recent theoretical and experimental studies have shed light on the complex network of interactions among the multiple classes of RNA within the cell. Although much of the focus over the past decade has been on the mechanisms by which microRNAs (miRNA) regulate the stability and translation of messenger RNAs (mRNAs), more recently it has come to light ...
Marcella, Cesana, George Q, Daley
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The mRNA related ceRNA–ceRNA landscape and significance across 20 major cancer types [PDF]

Nucleic Acids Research, 2015
Cross-talk between competitive endogenous RNAs (ceRNAs) through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of cancers. However, a global view of their system-level properties across various types of cancers is still unknown.
Xu, Juan, Li, Yongsheng, Lu, Jianping, Pan, Tao, Ding, Na, Wang, Zishan, Shao, Tingting, Zhang, Jinwen, Wang, Lihua, Li, Xia   +9 more
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Extensive ceRNA–ceRNA interaction networks mediated by miRNAs regulate development in multiple rhesus tissues [PDF]

Nucleic Acids Research, 2016
Crosstalk between RNAs mediated by shared microRNAs (miRNAs) represents a novel layer of gene regulation, which plays important roles in development. In this study, we analyzed time series expression data for coding genes and long non-coding RNAs (lncRNAs) to identify thousands of interactions among competitive endogenous RNAs (ceRNAs) in four rhesus ...
Xu, Juan, Feng, Lin, Han, Zujing, Li, Yongsheng, Wu, Aiwei, Shao, Tingting, Ding, Na, Li, Lili, Deng, Wei, Di, Xuebing, Wang, Jian, Zhang, Lianfeng, Li, Xia, Zhang, Kaitai, Cheng, Shujun   +14 more
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From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition [PDF]

Nature Structural & Molecular Biology, 2013
RNA is believed to have been the first reservoir of genetic information, but despite its ancient history, RNA continues to fascinate and is only now beginning to be understood in its entire variety and communication modality. New discoveries include the pseudogene RNA network regulating PTEN transcription and translation and the identification of ...
Riccardo Taulli, Cristian Loretelli, Pier Paolo Pandolfi   +2 more
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Perdarahan Saluran Cerna Atas

Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran, 2023
Upper gastrointestinal hemorrhage (PSCA) is bleeding from the lumen of the proximal gastrointestinal tract above the treitz ligament. The causes of PSCA can be classified into variceal bleeding and non-variceal bleeding. The most common causes of upper gastrointestinal bleeding are peptic ulcers, esophageal-gastric variceal veins, ulcerative ...
null Darmadi Darmadi, null Sania Audry Nasution   +1 more
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Aberrant ceRNA activity drives lung cancer [PDF]

Cell Research, 2014
In a recent issue of Nature, Kumar et al. demonstrate that the oncogenic potential of the Hmga2 gene is largely due to the ability of its transcript to operate as a competing endogenous RNA in a protein coding-independent manner. The Hmga2 mRNA decoys the let-7 microRNA family to regulate Tgfbr3 expression and enhance TGF-β signaling, thereby promoting
Yvonne, Tay, Florian A, Karreth, Pier Paolo, Pandolfi   +2 more
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The Functional Characterization of Epigenetically Related lncRNAs Involved in Dysregulated CeRNA–CeRNA Networks Across Eight Cancer Types [PDF]

Frontiers in Cell and Developmental Biology, 2021
Numerous studies have demonstrated that lncRNAs could compete with other RNAs to bind miRNAs, as competing endogenous RNAs (ceRNAs), to regulate each other. On the other hand, ceRNAs were found to be recurrently dysregulated in cancer status. However, limited studies considered the upstream epigenetic regulatory factors that disrupted the normal ...
Dahua Xu, Liqiang Wang, Sainan Pang, Meng Cao, Wenxiang Wang, Xiaorong Yu, Zhizhou Xu, Jiankai Xu, Hong Wang, Jianping Lu, Kongning Li, Kongning Li   +11 more
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