Results 11 to 20 of about 100,816 (310)
lncRNA-mediated ceRNA network in bladder cancer
Non-coding RNA Research, 2022 Bladder cancer is a common disease associated with high rates of morbidity and mortality. Although immunotherapy approaches such as adoptive T-cell therapy and immune checkpoint blockade have been investigated for the treatment of bladder cancer, their off-target effects and ability to affect only single targets have led to clinical outcomes that are ...
Kun Li, Tongyue Yao, Ziqiang Wang
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From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition [PDF]
Nature Structural & Molecular Biology, 2013 RNA is believed to have been the first reservoir of genetic information, but despite its ancient history, RNA continues to fascinate and is only now beginning to be understood in its entire variety and communication modality. New discoveries include the pseudogene RNA network regulating PTEN transcription and translation and the identification of ...
Riccardo Taulli +2 more
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Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression
Molecular Medicine Reports, 2019 The prevalence of mental health disorders such as depression is high. Depression is a multifactorial disorder and its underlying mechanisms remain unclear. Competing endogenous RNA (ceRNA) regulation has been reported to serve important roles in human disease.
Lang Yan, Jingchao Zhang, Zheng Wei Yuan
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miRTissue ce: extending miRTissue web service with the analysis of ceRNA-ceRNA interactions [PDF]
BMC Bioinformatics, 2020 Abstract Background Non-coding RNAs include different classes of molecules with regulatory functions. The most studied are microRNAs (miRNAs) that act directly inhibiting mRNA expression or protein translation through the interaction with a miRNAs-response element. Other RNA molecules participate in the complex network of gene regulation.
Antonino Fiannaca +4 more
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Frontiers in Immunology, 2023 Background Pre-mRNA processing factor 19 (PRPF19) is an E3 ligase that plays a crucial role in repairing tumor-damaged cells and promoting cell survival.
YaXuan Wang +7 more
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Deciphering the rules of ceRNA networks [PDF]
Proceedings of the National Academy of Sciences, 2013 Recent theoretical and experimental studies have shed light on the complex network of interactions among the multiple classes of RNA within the cell. Although much of the focus over the past decade has been on the mechanisms by which microRNAs (miRNA) regulate the stability and translation of messenger RNAs (mRNAs), more recently it has come to light ...
George Q. Daley, Marcella Cesana
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Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA
Cell Death and Differentiation, 2022 Ferroptosis, a novel form of regulated cell death induced by iron-dependent lipid peroxidation, plays an essential role in the development and drug resistance of tumors.
Ying Zhang +4 more
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Molecular Cancer, 2022 Background Esophageal squamous cell carcinoma (ESCC) is a common invasive malignancy worldwide with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been reported to be involved in cancer development. However, lncRNAs that
Song-tao Xue +6 more
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Roles of ncRNAs as ceRNAs in Gastric Cancer [PDF]
Genes, 2021 Although ignored in the past, with the recent deepening of research, significant progress has been made in the field of non-coding RNAs (ncRNAs). Accumulating evidence has revealed that microRNA (miRNA) response elements regulate RNA. Long ncRNAs, circular RNAs, pseudogenes, miRNAs, and messenger RNAs (mRNAs) form a competitive endogenous RNA (ceRNA ...
Junhong Ye, Jifu Li, Ping Zhao
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Journal of Nanobiotechnology, 2023 Purpose Endothelial cell dysfunction is a major cause of early atherosclerosis. Although the role of extracellular vesicles in stabilizing atherosclerotic plaques is well established, the effect of circulating exosomes on plaque formation is still ...
Xiao Tong +13 more
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